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Journals / Gülhane Tıp Dergisi / 2004 / Cilt: 46 - Sayı: 4

Comparison of transdermal and oral progestin combinations in transdermal estrogen replacement therapy: Effects on serum lipids and lipoproteins

Transdermal östrojen replasman tedavisinde transdermal ve oral progestin kombinasyonlarının serum lipid ve lipoproteinleri üzerine etkilerinin karşılaştırılması

Reşide ÖNALAN
Göğşen ÖNALAN
Leyla MOLLAMAHMUTOĞLU
FÜSUN BELGİN SELAM
Münire AKAR
Pages
311–314
DOI
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Argument: Transdermal and oral progestin combinations in transdermal estrogen replacement therapy have similar effects on serum lipids and lipoproteins

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: We compared metabolic effects of transdermal and oral progestin combinations in postmenopausal women receiving transdermal estrogen replacement therapy.
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Key Findings & Data:Study Design: One hundred fourteen postmenopausal women were randomized to receive either transdermal continous 17 â estradiol, 0.05 mg/day with transdermal cyclic norethisterone acetate, 0.25 mg/day or transdermal continous 17 â estradiol, 0.05 mg/day with oral cyclic medroxiprogesteron acetate, 10mg/day.
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Conclusion & Impact:Argument: Transdermal and oral progestin combinations in transdermal estrogen replacement therapy have similar effects on serum lipids and lipoproteins
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Kolesterol · Lipidler · Lipoproteinler

Abstract

Objective: We compared metabolic effects of transdermal and oral progestin combinations in postmenopausal women receiving transdermal estrogen replacement therapy. Study Design: One hundred fourteen postmenopausal women were randomized to receive either transdermal continous 17 â estradiol, 0.05 mg/day with transdermal cyclic norethisterone acetate, 0.25 mg/day or transdermal continous 17 â estradiol, 0.05 mg/day with oral cyclic medroxiprogesteron acetate, 10mg/day. Women in two groups were studied for one year. Lipoprotein profiles at 3,6 and 12 months were compared with baseline values by means of analysis of variance. Results: Plasma total cholesterol, low (LDL) and high (HDL) density lipoprotein and trigliserides were all significatly reduced. Argument: Transdermal and oral progestin combinations in transdermal estrogen replacement therapy have similar effects on serum lipids and lipoproteins

Özet

Amaç: Transdermal östrojen replasman tedavisi uygulanan postmenopozal kadınlarda, transdermal ve oral progestin kombinasyonlarının metabolik etkilerinin karşılaştırılması. Materyal Metod: 114 postmenopozal hasta, transdermal sürekli 17 β estradiol (0.05 mg/gün) ile birlikte transdermal norethisteron asetat 0.25 mg/gün veya transdermal sürekli 17 β estradiol (0.05 mg/gün) ile birlikte oral medroksi progesteron asetat (10 mg/gün) kullanmak üzere randomize olarak 2 gruba ayrıldı. Her iki grup 1 yıl süreyle takip edildi. Varyans analizi ile 3.,6. ve 12. ay lipoprotein profilleri bazal değerlerle karşılaştırıldı. Sonuçlar: 12 siklus sonunda, plazma total kolesterol, LDL ve trigliserid değerlerinin tümünde anlamlı düşüş saptandı. Tartışma: Transdermal östrojen replasman tedavisinde, transdermal ve oral progestin kombinasyonları serum lipid ve lipoproteinleri üzerine benzer etkiye sahiptir.

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Cite This Article

ÖNALAN, R., ÖNALAN, G., MOLLAMAHMUTOĞLU, L., SELAM, F. B., AKAR, M. (2004). Comparison of transdermal and oral progestin combinations in transdermal estrogen replacement therapy: Effects on serum lipids and lipoproteins. Gülhane Tıp Dergisi, Cilt: 46 - Sayı: 4, 311–314. https://ajindex.com/articles/226359

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References (12)

  1. Wassertheil-Smoller S, Hendrix SL, Limacher M, Heiss G, Kooperberg C, Baird A, Kotchen T, Curb JD, Black H, Rossouw JE, Aragaki A, Safford M, Stein E, Laowattana S, Mysiw WJ
  2. WHI Investigators. Effect of estrogen plus progestin on stroke in postmenopausal women: the Women's Health Initiative:a randomized trial. JAMA.2003 May 8
  3. 289(20):2673-84. 313 2. Kanaya AM, Herrington D, Vittinghoff E, Lin F, Grady D, Bittner V, Cauley JA, Barrett-Connor E
  4. Heart and Estrogen/progestin Replacement Study. Glycemic effects of postmenopausal hormone therapy: the Heart and Estrogen/progestin Replacement Study. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2003 Jan 7
  5. 138(1):1-9. 3. Mosca L, Appel LJ, Benjamin EJ, Berra K, Chandra-Strobos N, Fabunmi RP, Grady D, Haan CK, Hayes SN, Judelson DR, Keenan NL, McBride P, Oparil S, Ouyang P, Oz MC, Mendelsohn ME, Pasternak RC, Pinn VW, Robertson RM, Schenck-Gustafsson K, Sila CA, Smith SC Jr, Sopko G, Taylor AL, Walsh BW, Wenger NK, Williams CL Evidence-Based Guidelines for Cardiovascular Disease Prevention in Women. Circulation. 2004 Feb 4 4. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J
  6. Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA. 2002 Jul 17
  7. 288(3):321-33 5. Manson JE, Hsia J, Johnson KC, Rossouw JE, Assaf AR, Lasser NL, Trevisan M, Black HR, Heckbert SR, Detrano R, Strickland OL, Wong ND, Crouse JR, Stein E, Cushman M
  8. Women's Health Initiative Investigators. Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med. 2003 Aug 7
  9. 349(6):523-34. 6. Lobo RA, Bush T, Carr BR, Pickar JH.Effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate on plasma lipids and lipoproteins, coagulation factors, and carbohydrate metabolism. Fertil Steril. 2001 Jul
  10. 76(1):13-24. 7. Luciano AA, Miller BE, Schoenenfeld MJ, Schaser RJ
  11. Ogen/Provera Study Group. Effects of estrone sulfate alone or with medroxyprogesterone acetate on serum lipoprotein levels in postmenopausal women. Obstet Gynecol. 2001 Jan
  12. 97(1):101-8. 8. Legault C, Stefanick ML, Miller VT, Marcovina SM, Schrott HG. Effect of hormone replacement therapy on the validity of the Friedewald equation in postmenopausal women: the post