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Journals / Gülhane Tıp Dergisi / 2003 / Cilt: 45 - Sayı: 1

Evaluation of different dose HCG treatments in undescended testis

İnmemiş testisli olgularda farklı doz HCG tedavisinin değerlendirilmesi

Medine Ayşin TAŞAR
Zeynep ŞIKLAR
İlyas Mehmet ÇELİKER
Rukiye ÜNSAL
Ömer ERDEVE
Yıldız DALLAR
Pages
58–63
DOI
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⚡ TL;DR(Too Long; Didn't Read)

When 500U/m2/dose and 1500U/m2/dose HCG regimens are compared for children with undescended testis, the best response was obtained in cases with high scrotal located testes, but there is no statistical difference for success rates (p>0.05) in the other groups.

📌 3 Key Takeaways

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Objective & Hypothesis:The aim of this study was to evaluate and compare the activity of human chorionic gonodotropin (HCG) treatment with 500U/m2/dose and 1500U/m2/dose regimens for undescended testis cases at prepubertal children.Seventy one prepubertal children aged between 7 months-13 years (mean 4,2) were included to study.
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Key Findings & Data:Cases were ran-domized to two groups; 34 cases received 500U/m2/dose whereas 37 cases received 1500U/m2/dose HCG treatment twice a week for totally five doses.
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Conclusion & Impact:When 500U/m2/dose and 1500U/m2/dose HCG regimens are compared for children with undescended testis, the best response was obtained in cases with high scrotal located testes, but there is no statistical difference for success rates (p>0.05) in the other groups.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Testosteron · Koryonik gonadotropin · Kriptorşidizm

Abstract

The aim of this study was to evaluate and compare the activity of human chorionic gonodotropin (HCG) treatment with 500U/m2/dose and 1500U/m2/dose regimens for undescended testis cases at prepubertal children.Seventy one prepubertal children aged between 7 months-13 years (mean 4,2) were included to study. Cases with retractile testis, chromosomal anomalities and ectopic testis were excluded. Cases were ran-domized to two groups; 34 cases received 500U/m2/dose whereas 37 cases received 1500U/m2/dose HCG treatment twice a week for totally five doses. Testosteron and free testosteron levels were obtained before and after HCG administration. The response to treatment for 500U/m2/dose and 1500U/m2/dose were respectively 61.7% and 56.7% Sufficient testosteron response was obtained for both groups and no statistical difference was present (p>0.05). Success rates for bilateral and unilateral cases were 64.5% and 56% in order. High scrotal cases resulted with best responses. Orchiopexy was applied to unresponded cases. When 500U/m2/dose and 1500U/m2/dose HCG regimens are compared for children with undescended testis, the best response was obtained in cases with high scrotal located testes, but there is no statistical difference for success rates (p>0.05) in the other groups.

Özet

Bu çalışmanın amacı, inmemiş testisli çocuklarda iki farklı doz (500Ü/m2 ve 1500Ü/m2) human koriyonik gonodotropin (HCG) tedavisi öncesi ve sonrasını değerlendirmek ve karşılaştırmaktır. Ortalama yaşları 4.2 yaş (dağılım, 7 ay -13 yaş) olan 71 prepubertal çocuk çalışmaya alındı. Retraktil ve ektopik testisli olgular ve kromozomal anomalisi bulunanlar çalışmaya dahil edilmedi. Olgular randomize şekilde iki gruba ayrıldı. Otuzdört olguya 500U/m2/doz, 37 olguya da 1500U/m2/doz HCG haftada iki kez olmak üzere, toplam beş doz uygulandı. HCG öncesi ve sonrası serum testosteron (T) ve serbest testosteron (sT) düzeyleri belirlendi. Olguların tedaviye yanıt oranı 500Ü/m2/doz alan ve 1500Ü/m2/doz alan grupta sırasıyla %61.7 ve %56,7 idi. Her iki grupta yeterli testosteron yanıtı alındı ve gruplar arasında tedaviye yanıt açısından istatiksel anlamlı fark saptanmadı (p>0.05). Başarı oranları bilateral ve unilateral olgularda sırasıyla % 64.5 ve %56 idi. Yüksek skrotal yerleşimli olgularda ise başarı oranı (%100) oldu. Tedaviye yanıt vermeyen 29 olguya (%40) orşiyopeksi uygulandı. Sonuç olarak, inmemiş testisli çocuklarda haftada 2 kez olmak üzere toplam 5 kez 500Ü/m2/dozda uygulanan HCG tedavisi 1500Ü/m2/doz kadar etkindir.

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Cite This Article

TAŞAR, M. A., ŞIKLAR, Z., ÇELİKER, İ. M., ÜNSAL, R., ERDEVE, Ö., DALLAR, Y. (2003). Evaluation of different dose HCG treatments in undescended testis. Gülhane Tıp Dergisi, Cilt: 45 - Sayı: 1, 58–63. https://ajindex.com/articles/226278

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