Journals / Gülhane Tıp Dergisi / 2011 / Cilt: 53 - Sayı: 1

Proceeded diagnosis and therapy in eye diseases under the light of developments in molecular biology and genetics

Moleküler biyoloji ve genetikteki gelişmelerin ışığında göz hastalıklarında ileri tanı ve tedavi

Pages
74–76
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this article applications, gene therapy protocols and studies about stem cell regarding neoangiogenesis, which is one of the proceeeded diagnosis and therapy methods in cases with retinoblastoma, retinal dystrophia and macular degeneration that are among the main topics of ophthalmology are discussed.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Most of the eye diseases are in the group of diseases, in which many genes and factors are affected.
📊
Key Findings & Data:Recent improvements in molecular biology and genetics reveal new findings associated with the etiology.
💡
Conclusion & Impact:In this article applications, gene therapy protocols and studies about stem cell regarding neoangiogenesis, which is one of the proceeeded diagnosis and therapy methods in cases with retinoblastoma, retinal dystrophia and macular degeneration that are among the main topics of ophthalmology are discussed.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Most of the eye diseases are in the group of diseases, in which many genes and factors are affected. Recent improvements in molecular biology and genetics reveal new findings associated with the etiology. In this article applications, gene therapy protocols and studies about stem cell regarding neoangiogenesis, which is one of the proceeeded diagnosis and therapy methods in cases with retinoblastoma, retinal dystrophia and macular degeneration that are among the main topics of ophthalmology are discussed.

Özet

Göz hastalıklarının birçoğu etiyolojik olarak birçok gen ve faktörün etkilendiği hastalıklar grubundadır. Moleküler biyoloji ve genetikteki gelişmeler göz hastalıklarında etiyoloji ile ilgili yeni bulguları ortaya koymaktadır. Bu yazıda göz hastalıkları içinde önemli bir yer tutan retinoblastoma, retinal distrofi ve maküler dejenerasyon olgularında ileri tanı ve tedavi yöntemleri içinde yer alan yeni kılcal damar oluşturma ile ilgili uygulamalar, gen tedavi protokolleri ve kök hücre çalışmaları tartışılmaktadır.

🔖

Cite This Article

GÜRAN, Ş. (2011). Proceeded diagnosis and therapy in eye diseases under the light of developments in molecular biology and genetics. Gülhane Tıp Dergisi, Cilt: 53 - Sayı: 1, 74–76. https://ajindex.com/articles/225383

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Rimoin DL, Connor JM, Pyeritz RE, Korf BR. Emery and Rimoin’s Principles and Practice of Medical Genetics. New York: Churchill Livingston, 2007: 29-46
  2. Guran S, Torun D, Mutlu FM, Uysal Y, Ugurel MS, Bahce M. A new syndrome associated with absence of lower lid lacrimal punctum, ptosis, elevation deficiency of both eyes and mild facial dysmorphism. Ophthalmic Genet 2009; 30: 146-151
  3. Marin S. Inherited Eye Diseases: Diagnosis and Management. New York: Taylor and Francis Group, 2005: 46-104
  4. Poulaki V, Mukai S. Retinoblastoma: genetics and pathology. Int Ophthalmol Clin 2009; 49: 155-164
  5. Koenekoop RK, Lopez I, den Hollander AI, Allikmets R, Cremers FP. Genetic testing for retinal dystrophies and dysfunctions: benefits, dilemmas and solutions. Clin Experiment Ophthalmol 2007; 35: 473-485
  6. Yang LP, Wu LM, Guo XJ, Li Y, Tso MO. Endoplasmic reticulum stress is activated in light-induced retinal degeneration. J Neurosci Res 2008; 86: 910-919
  7. Güran Ş. Hastalıklara yeni bir tanı yaklaşımı: proteinçip teknolojisi. Gülhane Tıp Derg 2005; 47: 243-245
  8. Yoo SM, Choi JH, Lee SY, Yoo NC. Applications of DNA microarray in disease diagnostics. J Microbiol Biotechnol 2009; 19: 635-646
  9. Natarajan K, Shepard LA, Chodosh J. The use of DNA array technology in studies of ocular viral pathogenesis. DNA Cell Biol 2002; 21: 483-490. 10. den Hollander AI, Lopez I, Yzer S, et al. Identification of novel mutations in patients with Leber congenital amaurosis and juvenile RP by genome-wide homozygosity mapping with SNP microarrays. Invest Ophthalmol Vis Sci 2007; 48: 5690-5698
  10. Cantsilieris S, Schache M, Ashdown ML, Baird PN. Recent patents relating to diagnostic advances in age related macular degeneration (AMD). Recent Pat DNA Gene Seq 2009; 3: 102-113
  11. Torquetti L, Castanheira P, de Góes AM, Marcio N. Stem cells: potential source for retinal repair and regeneration. Arq Bras Oftalmol 2007; 70: 371-375
  12. Güran Ş. Kalp yetmezliğinde anjiyogenezis ve gen tedavisi. Gülhane Tıp Derg 2004; 46: 84-87
  13. Naldini L. Medicine. A comeback for gene therapy. Science 2009; 326: 805-806
  14. Baker PS, Brown GC. Stem-cell therapy in retinal disease. Curr Opin Ophthalmol 2009; 20: 175-181
  15. Castanheira P, Torquetti L, Nehemy MB, Goes AM. Retinal incorporation and differentiation of mesenchymal stem cells intravitreally injected in the injured retina of rats. Arq Bras Oftalmol 2008; 71: 644-650
  16. Cremers FP, Collin RW. Promises and challenges of genetic