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Journals / Genel Tıp Dergisi / 2000 / Cilt: 10 - Sayı: 3

At postmenopausal patient comparement of tibolone and calcium usage by calcium usage alone on bone mineral density

Postmenapozal kadınlarda kemik mineral yoğunluğu üzerine tibolon ve kalsiyum ile sadece kalsiyum kullanımının karşılaştırılması

EKREM SAPMAZ
Hüsnü ÇELİK
A. Kasım BALTACI
Rasim MOĞULKOÇ
Pages
97–101
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Increase in bone density is much more at group I than group II( p<0.05 Mann Whitney U test) Conclusion: As result usage of tibolone and calcium at postmenopausal osteoporosis management is more effective than calcium usage alone.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: At postmenopausal osteoporosis managment the effect of Tibolone (2.5 mg/po/d) and calcium (1gr/po/d) usage on femur neck and vertebra is evaluated.
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Key Findings & Data:Method: The study is a randomised one side blighted prospective one .Forthy-one postmenopausal patients encountered the study; 21 patients received tibolone and calcium(Group I), the rest 20 patients received calcium alone(Grup II) .
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Conclusion & Impact:Increase in bone density is much more at group I than group II( p<0.05 Mann Whitney U test) Conclusion: As result usage of tibolone and calcium at postmenopausal osteoporosis management is more effective than calcium usage alone.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:İlaç kombinasyonları · Postmenopoz · Osteoporoz

Abstract

Objective: At postmenopausal osteoporosis managment the effect of Tibolone (2.5 mg/po/d) and calcium (1gr/po/d) usage on femur neck and vertebra is evaluated. Method: The study is a randomised one side blighted prospective one .Forthy-one postmenopausal patients encountered the study; 21 patients received tibolone and calcium(Group I), the rest 20 patients received calcium alone(Grup II) . At 0 th .,12., th 24., th months bone densitometry is taken. Major Findings: In both groups comparement is done inside the each groups and it's observed that bone density is increased at both femur neck and vertebral bones (Kendall's W test p<0.05 ve Wilcoxon rank test p<0.05). Increase in bone density is much more at group I than group II( p<0.05 Mann Whitney U test) Conclusion: As result usage of tibolone and calcium at postmenopausal osteoporosis management is more effective than calcium usage alone.

Özet

Amaç: Bu çalışmada Postmenapozal osteoporoz tedavisinde tibolon (2.5 mg/po/gün) ve kalsiyum (1g/po/gün) kullanımı ile sadece kalsiyum (1g/po/gün) kullanımının kortikal ve trabeküler kemik yoğunluğu üzerine etkinliği araştırıldı. Yöntem: Randomize, tek kör, prospektif çalışma kapsamına alınan 41 postmenapozal hastadan, 21 hastaya tibolon ve kalsiyum (Grup I=çalışma ), 20 hastaya ise sadece kalsiyum (Grup II=kontrol) verilerek 0., 12. ve 24. aylardaki kemik mineral yoğunluğu belirlendi. Bulgular: Grup içi karşılaştırma yapıldığında başlangıç değerleri ile karşılaştırıldığında her iki grupta gerek kortikal gerekse trabeküler kemik yoğunluğunda anlamlı artışlar tespit edildi ( Kendall's W testi, p<0.05 ve Wilcoxon rank testi, p<0.05). Gruplar arası karşılaştırmada ise çalışma grubundaki artış kontrol grubuna göre daha anlamlı bulundu (p<0.05, Mann Whitney U testi). Sonuç: Postmenapozal osteoporozun önlenmesinde Tibolon ve kalsiyum kullanımı sadece kalsiyum kullanımına göre daha etkili bulundu.

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Cite This Article

SAPMAZ, E., ÇELİK, H., BALTACI, A. K., MOĞULKOÇ, R. (2000). At postmenopausal patient comparement of tibolone and calcium usage by calcium usage alone on bone mineral density. Genel Tıp Dergisi, Cilt: 10 - Sayı: 3, 97–101. https://ajindex.com/articles/225070

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