Coronary artery disease and Chlamydia pneumoniae

Objective & Hypothesis:Objective: Recent studies suggested that atherosclerosis may be associated with some bacterial ör viral agents. in this study we aimed to investigate the relationship betvveen Chlamydia pneumoniae (C. pneumoniae) infection and the atherosclerotic coronary artery disease (CAD).

📊

Key Findings & Data:Methods: Twenty-one patients with CAD and 17 healthy people were recruited for this case-control study.

💡

Conclusion & Impact:Conclusions: Our results indicate no association between C. pneumoniae infection and CAD.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Koroner arteriyoskleroz · Koroner hastalık · Chlamydia pneumoniae

Abstract

Objective: Recent studies suggested that atherosclerosis may be associated with some bacterial ör viral agents. in this study we aimed to investigate the relationship betvveen Chlamydia pneumoniae (C. pneumoniae) infection and the atherosclerotic coronary artery disease (CAD). Methods: Twenty-one patients with CAD and 17 healthy people were recruited for this case-control study. Venous blood was taken from the patients before the coronary artery bypass greft operation. Immunoglobulip G type antibodies against Chlamydia lipopolysaccharide (cLPS) antigen were analyzed using a commercial ELISA in serums obtained from patients and control subjects. Results: Eleven of the 21 patients (52.4%) and 6 of the 17 control subjects (35.3%) were seropositive for cLPS. Although the rate of the seropositivity of the patients were higher than that of controls, there was no statistically signifıcant difference betvveen the groups (P=0.468). Conclusions: Our results indicate no association between C. pneumoniae infection and CAD.

Özet

Amaç: Son yıllarda yapılan bazı çalışmalar aterosklerozun bazı bakteriyel ve viral etkenlerle ilişkili olabileceğini düşündürmektedir. Bu çalışmada Chlamydia pneumoniae (C. pneumoniae) infeksiyonu ile aterosklerotik koroner arter hastalığı (KAH) arasında bir bağlantı olup olmadığının araştırılması amaçlandı. Yöntem: Koroner arter hastalığı tanısı konan 21 hasta ve 17 sağlıklı birey bu vaka-kontrol çalışmasına dahil edildi. Hastalardan koroner arter bypass greft cerrahisi öncesi venöz kan alındı. Hasta ve kontrol grubundan elde edilen serumlarda Klamidyal lipopolisakkarit (cLPS) antijenine karşı gelişen IgG tipi antikorlar bir ticari ELISA kiti kullanılarak belirlendi. Bulgular: Yirmibir hastanın 11'inde (% 52.4), 17 kontrol olgusunun 6'smda (% 35.3) cLPS seropozitifliği tespit edildi. Hastalarda elde edilen seropozitiflik kontrol grubundakinden daha yüksek bulunmasına rağmen iki grup arasında istatistiksel olarak anlamlı bir fark görülmedi (P=0.468). Sonuç: Sonuçlarımız C. pneumoniae infeksiyonu ile KAH arasında ilişki olduğu hipotezini desteklememektedir.

Keywords

Koroner arteriyoskleroz Koroner hastalık Chlamydia pneumoniae Ateroskleroz Coronary Arteriosclerosis Coronary Disease Atherosclerosis

🔖

Cite This Article

KAKLIKKAYA, İ., KAKLIKKAYA, N., SANCAKTAR, M., ÖZCAN, F. (2001). Coronary artery disease and Chlamydia pneumoniae. Genel Tıp Dergisi, Cilt: 11 - Sayı: 4, 135–138. https://ajindex.com/articles/225051

📄 Full Text PDF Viewer

Open in New Tab ↗

↗New Tab

📄

PDF görüntüleyici hazırlanıyor...

References (11)

Grayston JT, Campbell LA, Kuo CC, Mordhorst CH, Saikku P, Thom DH, et al. A new respratory tract pathogen: Chlamydia pneumoniae strain TWAR. J Infect Dis 1990;161:618-25. Grayston JT. Infections caused by Chlamydia pneumoniae strain TWAR. Clin Infect Dis 1992;15:757-63.
Ossewaarde JM, Feskens EJ, De Vries A, Vallinga CE, Kromhout D. Chlamydia pneumoniae is a risk factor for coronary heart disease in symptom-free elderly men, but Helicobacter pylori and Cytomegalovirus are not. Epidemiol Infect 1998;120:93-9.
Carlsson J, Miketic S, Brom J, Ross R, Bachmann H, Tebbe U. Prior Cytomegalovirus, Chlamydia or Helicobacter pylori infection and risk of restenosis after percutaneus transluminal coronary angioplasty. Int J Cardiology 2000;73:165-71.
Kuo CC, Coulson AS, Campbell LA, Cappuccio AL, Lawrence RD, Wang SP, et al. Detection of Chlamydia pneumoniae in atherosclerotic plaques in the walls of arteries of lower extremities from patients undergoing bypass operation for arterial obstruction. J Vasc Surg 1997;26: 29-31.
Ingalls RR, Rice PA, Qureshi N, Tkayam K, Lin JS, Golenbock DT. Inflammatory cytokine response to Chlamydia trachomatis is entotoxin mediated. Infect Immun 1995;63:3125-30.
Heinemann M, Susa M, Simnacher U, Matte R, Essig A. Growth of Chlamydia pneumoniae induces cytokine production and expression of CD14 in a human monocytic cell line. Infect Immun 1996;75:573-5.
Cabana VG, Siegel JN, Sabesin SM. Effects of the acute phase response on the concentration and density distribution of plasma lipids and lipoproteins. J Lipid Res 1989;30:39-49. Ernst E. Fibrinogen as a cardiovascular risk factor-interrelationship with infection and inflammation. Eur Heart J 1993;4:82-7. In: Leinonen M. Chlamydia pneumoniae and other risk factors for atherosclerosis. J Infect Dis 2000;181:414-6.
Saikku P, Leinonen M, Mattila K, Ekman MR, Nieminen MS, Makela PH, et al. Serological evidence of an association of a novel Chlamydia, TWAR, with chronic coronary heart disease and acute myocardial infarction. Lancet 1988;2:983-6.
Saikku P, Leinonen M, Tenkanen L, Linnanmaki E, Ekman MR, Manninen V, et al. Chronic Chlamydia pneumoniae infection as a risk factor for coronary heart disease in the Helsinki Heart Study. Ann Intern Med 1992;116:273-8.
Miettinen H, Lehto S, Saikku P. Association of Chlamydia pneumoniae and acute coronary heart disease in non-insulin-dependent diabetic and non-diabetic subjects in Finland. Eur Heart J 1996;17:682-8.
Hoffmeister A, Rothenbacher D, Wanner