Journals / Türk Göğüs Kalp Damar Cerrahisi Dergisi / 2001 / Cilt: 9 - Sayı: 3

Coronary artery disease and Helicobacter pylori

Koroner arter hastalığı ve Helicobacter pylori

Pages
142–144
Publication Date
2022-09-02
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusions: These data do not support the hypothesis that infection with Helicobacter pylori might be a major risk factor for CAD.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background: There is some evidence that chronic inflammation may have a potential role in the pathogenesis of atherosclerosis.
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Key Findings & Data:Methods: In this study anti-Helicobacter pylori IgG was determined by in-house ELISA in preoperative serums from 38 patients with CAD.
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Conclusion & Impact:Conclusions: These data do not support the hypothesis that infection with Helicobacter pylori might be a major risk factor for CAD.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: There is some evidence that chronic inflammation may have a potential role in the pathogenesis of atherosclerosis. But the relationship between Helicobacter pylori infection and atherosclerotic coronary artery disease (CAD) is conflicting. In our study we examined the relationship between seropositivity to Helicobacter pylori and CAD. Methods: In this study anti-Helicobacter pylori IgG was determined by in-house ELISA in preoperative serums from 38 patients with CAD. Thirty eight healthy people were recruited as the control group. Results: Twenty nine of the patients (%76.31) and 26 of the controls (%68.42) have anti-Helicobacter pylori IgG. There were no association between the results of the patients with CAD and controls. Conclusions: These data do not support the hypothesis that infection with Helicobacter pylori might be a major risk factor for CAD.

Özet

Amaç: Aterosklerozun patogenezinde kronik infeksiyonların potansiyel bir rolünün olabileceğine dair bazı deliller mevcuttur. Ancak Helicobacter pylori infeksiyonu ile aterosklerotik koroner arter hastalığı (KAH) arasındaki ilişki tartışmalıdır. Çalışmamızda Helicobacter pylori seropozitivitesi ile KAH arasındaki bağlantı olup olmadığı araştırıldı. Materyal ve Metod: Bu çalışmada KAH tanısı konan ve koroner arter bypass greft (KABG) ameliyatı yapılan 38 hastanın operasyondan bir gün önce alınan serum örneklerinde, in-house ELISA yöntemi ile anti-Helicobacter pylori IgG antikor varlığı araştırıldı. Kontrol grubu olarak 38 sağlıklı kişiden alınan serum örnekleri kullanıldı. Bulgular: Hastaların 29'unda (%76.31), kontrol grubunun 26'sında (%68.42) anti-Helicobacter pylori IgG antikorları tespit edildi. Koroner arter hastalığı bulunan grupta ve kontrol grubunda elde edilen sonuçlar arasında istatistiksel olarak anlamlı bir fark bulunmadı. Sonuç: Bu sonuçlar Helicobacter pylori infeksiyonunun KAH oluşumunda majör bir risk faktörü olduğu hipotezini desteklememektedir.

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Cite This Article

KAKLIKKAYA, İ., KAKLIKKAYA, N., KOCAZEYBEK, B., ÇUBUKÇU, K., SÖNMEZ, B. (2022). Coronary artery disease and Helicobacter pylori. Türk Göğüs Kalp Damar Cerrahisi Dergisi, Cilt: 9 - Sayı: 3, 142–144. https://ajindex.com/articles/425502

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