Journals / Gülhane Tıp Dergisi / 2012 / Cilt: 54 - Sayı: 3

Türkiye’nin güneybatı bölgesinde Hodgkin lenfomanın epidemiyolojisi ve histolojik alt tipleri

Epidemiology and histological subtypes of Hodgkin lymphoma in the south-west of Turkey

Pages
216–219
DOI
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⚡ TL;DR(Too Long; Didn't Read)

In conclusion, the epidemiological findings on Hodgkin’s lymphoma in Turkey are similar in general to those reported in the Western literature.

📌 3 Key Takeaways

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Objective & Hypothesis:Lymphomas are solid tumors of the immune system, and are diseases characterized by interrupted differentiation of lymphocytes, which are major components of the system, at various phases and their clonal proliferation.
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Key Findings & Data:In this article, the epidemiology of Hodgkin’s lymphoma and the factors influencing the frequency of its histological subtypes, with the populationbased data of 1994 to 2010 from Antalya Cancer Registration Center are discussed.
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Conclusion & Impact:In conclusion, the epidemiological findings on Hodgkin’s lymphoma in Turkey are similar in general to those reported in the Western literature.
🔬Design:Research Article
📍Scope:2010 Verileri
⚙️Variables:Hodgkin hastalığı · Yaş grupları · Epidemiyoloji

Abstract

Lymphomas are solid tumors of the immune system, and are diseases characterized by interrupted differentiation of lymphocytes, which are major components of the system, at various phases and their clonal proliferation. In this article, the epidemiology of Hodgkin’s lymphoma and the factors influencing the frequency of its histological subtypes, with the populationbased data of 1994 to 2010 from Antalya Cancer Registration Center are discussed. The study covered patients who were histopathologically diagnosed to have Hodgkin’s lymphoma from 1994 to 2010. The study involved 454 patients, 284 (62.6%) males and 170 (37.4%) females. Male/female ratio was found as 1.67. The average age of all patients was identified as 36.6±18.9 years and their median age was 34 (range 2-88) years. Changes in histological subtypes were studied with respect to years. Nodular sclerosis subtype predominated over time. In conclusion, the epidemiological findings on Hodgkin’s lymphoma in Turkey are similar in general to those reported in the Western literature. The frequency of histological subtypes is associated with sex, age and the occurence of EBV infection. Further studies are required to determine the factors that play role in the etiology of this disease, which is frequent in Turkey, and to shed light on its pathogenesis.

Özet

Lenfomalar, immün sistemin solid tümörleridir ve bu sistemin önemli bir bileşeni olan lenfositlerin farklılaşmasının çeşitli aşamalarda durması ve klonal proliferasyonu ile karakterize bir hastalık grubudur. Bu yazıda Antalya Kanser Kayıt Merkezinin nüfus tabanlı 1994-2010 verileri eşliğinde Hodgkin lenfoma epidemiyolojisi ve histolojik alt tiplerinin sıklığına etki eden faktörler tartışılmıştır. Çalışmaya 1994 ile 2010 yılları arasında histopatolojik olarak Hodgkin lenfoma tanısı konulan hastalar alınmıştır. Çalışmaya 284’ü (%62.6) erkek, 170’i (%37.4) kadın toplam 454 hasta alındı. Erkek/kadın oranı 1.67 olarak bulundu. Hastaların ortalama yaşı 36.6±18.9 yıl ve mediyan yaşı 34 (2-88) yıl olarak saptandı. Histolojik alt tiplerin yıllara göre değişimi incelendi. Nodüler sklerozan tipin zaman içinde giderek daha baskın duruma geldiği saptandı. Sonuç olarak Türkiye’de Hodgkin lenfomanın epidemiyolojik bulguları genel olarak batı literatürü ile benzerlik göstermektedir. Histolojik alt tiplerin görülme sıklığı cinsiyet, yaş ve EBV enfeksiyonu görülmesi ile ilişkilidir. Ülkemizde sık görülen bu hastalığın etiyolojisinde rol oynayan faktörlerin belirlenmesi ve patogenezinin aydılatılması için daha fazla sayıda çalışma yapılmasına ihtiyaç vardır.

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Cite This Article

YILDIRIM, M., YILDIZ, M., KURTOĞLU, E., KARAKILINÇ, H., DİLLİ, U. D., GÖKTAŞ, S. (2012). Türkiye’nin güneybatı bölgesinde Hodgkin lenfomanın epidemiyolojisi ve histolojik alt tipleri. Gülhane Tıp Dergisi, Cilt: 54 - Sayı: 3, 216–219. https://ajindex.com/articles/224882

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