Journals / Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi / 2000 / Cilt: 5 - Sayı: 2

The role of procalcitonin in diagnosis of different bacterial infections

Farklı bakteriyel infeksiyonların tanısında prokalsitoninin rolü

Pages
99–103
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

PCT levels increased in patients with bacterial infections like CRP but PCT was a more valuable marker than CRP for indicating the severity of infection.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:It is reported that procalcitonin (PCT), the precursor of calcitonin is elevated in patients with severe bacterial infections.
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Key Findings & Data:Six brusellosis, 8 systemic salmonellosis, 9 bacterial meningitis, 11 sepsis, total 33 patients and 20 healthy adults as control group were included in the study.
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Conclusion & Impact:PCT levels increased in patients with bacterial infections like CRP but PCT was a more valuable marker than CRP for indicating the severity of infection.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Kalsitonin · Bakteriyel enfeksiyonlar · Sepsis

Abstract

It is reported that procalcitonin (PCT), the precursor of calcitonin is elevated in patients with severe bacterial infections. In this study our aim is to determine the value of PCT in different bacterial infections and sepsis as a marker of infection. Six brusellosis, 8 systemic salmonellosis, 9 bacterial meningitis, 11 sepsis, total 33 patients and 20 healthy adults as control group were included in the study. PCT value was measured and compared by diagnostic value of C-reactive protein (CRP). PCT determination was performed by immu-noluminometric assay (Brahms Diagnostica Lumitest, PCT, Berlin). A significant difference was found between all patients and control group for both tests. There were significant differences between PCT concentrations in sepsis and other bacterial infections but no difference was found for CRP. PCT levels increased in patients with bacterial infections like CRP but PCT was a more valuable marker than CRP for indicating the severity of infection.

Özet

Temelde kalsitoninin öncül molekülü olan prokalsitonin (PCT)'in ciddi bakteriyel infeksiyonlarda serumda arttığı bildirilmektedir. Bu çalışmada farklı bakteriyel infeksiyonlar ve sepsiste infeksiyon göstergesi olarak PCT'nin değerini belirlemek amaçlanmıştır. AItı bruselloz, 8 sistemik salmonelloz, 9 bakteriyel menenjit, 11 sepsis olmak üzere toplam 33 hasta ve 20 sağlıklı erişkin serumunda PCT değeri belirlenmiş ve C-reaktif protein (CRP)'nin tanısal değeri ile karşılaştırmıştır. PCT değerinin saptanmasında immünoluminometrik yöntem (Brahms Diagnostica Lumitest, PCT, Berlin) kullanılmıştır. Tüm hastalar ile kontrol grubu arasında her iki test açısından anlamlı fark bulunmuştur. Sepsis ile diğer bakteriyel infeksiyonlar kaşılaştırıldığında ise CRP'de fark yokken PCT sepsis hastalarında anlamlı derecede yüksek saptanmıştır. PCT'nin CRP'ye benzer şekilde tüm bakteriyel infeksiyonlarda yükseldiği ve infeksiyonun ciddiyetini belirlemede CRP'den daha değerli bir gösterge olduğu sonucuna varılmıştır.

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Cite This Article

TUNÇBİLEK, S., BAYKAM, N., HIZEL, K., DOKUZOĞUZ, B. (2000). The role of procalcitonin in diagnosis of different bacterial infections. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, Cilt: 5 - Sayı: 2, 99–103. https://ajindex.com/articles/224474

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