SavedAdd your journal

Journals / Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi / 2002 / Cilt: 7 - Sayı: 1

Comparison of efficacy and safety of doxycycline + rifampin combination versus rifampin + trimethoprim-sulfamethoxazole combination in the treatment of Brucellosis

Bruselloz tedavisinde rifampisin + doksisiklin kombinasyonunun etkinliğinin ve güvenirliğinin rifampisin + trimetoprim-sülfametoksazol kombinasyonu ile karşılaştırılması

Ayşe ERBAY
Sebahat T. MEMİŞ
Nurcan BAYKAM
Başak DOKUZOĞUZ
Pages
44–48
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

No statistically significant difference was found between the two regimens but early clinical response was observed in rifampin plus trimethoprim sulfamet-hoxazole combination.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Brucellosis is a zoonosis existing worldwide.
📊
Key Findings & Data:In our study 50 cases of acute brucellosis were examined prospectively to compare the efficacy of doxycycline plus rifampin versus rifampin plus trimethoprim-sulfamethoxazole combinations.
💡
Conclusion & Impact:No statistically significant difference was found between the two regimens but early clinical response was observed in rifampin plus trimethoprim sulfamet-hoxazole combination.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:İlaç değerlendirmesi · Doksisiklin · Bruselloz

Abstract

Brucellosis is a zoonosis existing worldwide. Although a variety of combinations of drugs have been used in the treatment of brucellosis, the best regimen has not been clearly determined. In our study 50 cases of acute brucellosis were examined prospectively to compare the efficacy of doxycycline plus rifampin versus rifampin plus trimethoprim-sulfamethoxazole combinations. No statistically significant difference was found between the two regimens but early clinical response was observed in rifampin plus trimethoprim sulfamet-hoxazole combination.

Özet

Bruselloz, dünyada pekçok ülkeyi etkileyen bir zoonozdur. Bruselloz tedavisinde çok çeşitli ilaç kombinasyonları kullanılmasına rağmen en iyi rejimin hangisi olduğu kesin olarak tammlanmamıştır. Çalışmamızda, rifampisin + doksisiklin ve rifampisin + trimetoprim-sülfametoksazol (TMP-SMZ) kombinasyonu alan 50 hasta prospektif olarak incelenerek her iki tedavi semasının etkinliği karşılaştırmıştır. Bu kombinasyonların etkinlikleri karşılaştırıldığında istatistiksel olarak anlamlı bir fark bulunmamıştır, ancak rifampisin + TMP-SMZ kombinasyonuyla daha kısa sürede klinik cevap alındığı gözlenmiştir.

🔖

Cite This Article

ERBAY, A., MEMİŞ, S. T., BAYKAM, N., DOKUZOĞUZ, B. (2002). Comparison of efficacy and safety of doxycycline + rifampin combination versus rifampin + trimethoprim-sulfamethoxazole combination in the treatment of Brucellosis. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, Cilt: 7 - Sayı: 1, 44–48. https://ajindex.com/articles/224462

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Young EJ. Bruceîla species. In: Mandell GL, Bennett JE, Dolin R (eds). Principles and Practice of Infectious Diseases. 5th ed. Philadelphia: Churchill Livingstone Inc,2000:2389-93
  2. Gotuzzo E, Cellito C. Brucella. In: Gorbach SL, Bartlett JG, Blacklow NR (eds). Infectious Diseases. 1st ed. Philadelphia: WB Saunders Company, 1992:1513-21. 3. al-Sibai MB, Halim MA, el-Shaker MM, Khan BA, Qadri SM. Efficacy of ciprofloxacin for treatment of Brucella melitensis infections. Antimicrob Agents Chemother 1992;36:150-2
  3. Me Lean DR, Russel N, Khan MY. Neurobrucellosis: Clinical and therapeutic features. Clin Infect Dis 1992;15:582-90
  4. Lai S, Modawal KK, Fowle ASE, et.al. Acute brucellosis treated with trimetoprim and sulphamethoxazole. BMJ 1970;3:256-7
  5. Montejo I, Alberola P, Glez-Zarate P, et al. Open, randomized therapeutic trial of six antimicrobial regimens in the treatment of human brucellosis. Clin Infect Dis 1993;16:671-6
  6. Sözen TH. Bruselloz. Willke A, Söyletir G, Doğanay M (editörler). İnfeksiyon Hastalıkları. Nobel Tıp Kitabevi,1996:486-91
  7. Radolf JD. Southwestern International Medicine Conference: Brucellosis: Don't let it get your goat!. Am J Med Sci 1994;307:64-75
  8. Bilgehan H. Brusella, Klinik Mikrobiyoloji, Özel Bakteriyoloji ve Bakteri tnfeksiyonlan. Barış Yayınları, 1992:155-6
  9. Ariza J, Pujol M, Valverde J, et al. Brucellar sacroiliitis: Findings in 63 episodes and current relevance. Clin Infect Dis 1993;16:761-5
  10. Solera J, Martinez-Alfaro E, Espinosa A. Recognition and optimum treatment of brucellosis. Drugs 1997;53:245-56
  11. Clarridge JE. Miscellaneous gram-negative coccobacilli In: Howard BJ (ed). Clinical and Pathogenic Microbiology. St Louis Washington DC Toronto: The CV Mosby Company, 1987:435-54
  12. Zumla A, Geraint J. Granulamatous infections: Etiology and classification. Clin Infect Dis 1996;23:146-58
  13. WHO joint FAO/WHO, Expert commitee on Brucellosis, G. Report, technical report series, 1986;740 WHO,Geneva
  14. Hendricks MK, Perez EM, Burger PJ, et al. Brucellosis in childhood in Western Cape. S Afr Med J 1995;85:176-8
  15. Acocella G, Bertrand A, Beytout J, et al. Comparison of three different regimens in the treatment of acute brucellosis: A multicenter multinational study. J Antimicrob Chemother 1989;23:433-9
  16. El S, Ural S, Kaptan F, Müftüoglu I, Coşkun NA. Bruselloz tedavisinde siprofloksasin/rifampisin kombinasyonunun etkinliğinin ve güvenirliğinin doksisiklin/rifampisin kombinasyonunki ile kar