Journals / Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi / 2021 / Cilt: 26 - Sayı: 1

Classical Methods and New Developments in Laboratory Diagnosis of Fungal Infections

Mantar İnfeksiyonlarının Laboratuvar Tanısında Klasik Yöntemler ve Yeni Gelişmeler

Pages
34–49
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The aim of this review was to summarize the conventional and non-conventional laboratory diagnostic tests used for fungal diagnosis with their advantages and disadvantages.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Diseases caused by fungi affect a large number of people in the world.
📊
Key Findings & Data:Recently, the increase of diseases and treatment applications that suppress the immune system has caused a rise in the frequency and variety of fungal infections.
💡
Conclusion & Impact:The aim of this review was to summarize the conventional and non-conventional laboratory diagnostic tests used for fungal diagnosis with their advantages and disadvantages.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Diseases caused by fungi affect a large number of people in the world. Recently, the increase of diseases and treatment applications that suppress the immune system has caused a rise in the frequency and variety of fungal infections. This has complicated timely and definitive diagnosis and increased the need for more successful diagnostic approaches. New methods are developed especially for the diagnosis of invasive fungal infections in order to provide early and correct diagnosis and improve prognosis in vulnerable patients. For this purpose, the performances of new tests defined are evaluated in different patient groups and for different pathogens. Those found suitable are added to diagnostic algorithms. The aim of this review was to summarize the conventional and non-conventional laboratory diagnostic tests used for fungal diagnosis with their advantages and disadvantages.

Özet

Mantarların etken olduğu hastalıklar dünyada çok sayıda kişiyi etkilemektedir. Son zamanlarda bağışıklık sistemini baskılayan hastalık-ların ve tedavi uygulamalarının artması, mantar infeksiyonlarının sıklığı ve çeşitliliğinde artışa neden olmuştur. Bu durum, zamanında ve kesin tanıyı zorlaştırmış ve daha başarılı tanısal yaklaşımlara gereksinimini artırmıştır. Özellikle invaziv mantar infeksiyonlarının tanısında yeni yöntemler geliştirilerek risk altındaki hastalarda erken dönemde doğru tanının konması ve prognozun iyileştirilmesine çalışılmaktadır. Bu amaçla, tanımlanan yeni testlerin farklı hasta gruplarında ve farklı patojenler için performansları değerlendirilmek-tedir. Uygun bulunanlar tanı algoritmalarına eklenmektedir. Bu derlemede mantar infeksiyonlarının tanısı için kullanılan konvansiyonel ve non-konvansiyonel laboratuvar tanı testlerinin avantaj ve dezavantajları ile özetlenmesi amaçlanmıştır.

🔖

Cite This Article

GÜLMEZ, D., ALP, Ş. (2021). Classical Methods and New Developments in Laboratory Diagnosis of Fungal Infections. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, Cilt: 26 - Sayı: 1, 34–49. https://ajindex.com/articles/224331

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Kohler JR, Casadevall A, Perfect J. The spectrum of fungi that infects humans. Cold Spring Harb Perspect Med 2014;5:a019273
  2. Richardson M, Lass-Florl C. Changing epidemiology of systemic fungal infections. Clin Microbiol Infect 2008;14(Suppl 4):5-24
  3. Cole DC, Govender NP, Chakrabarti A, Sacarlal J, Denning DW. Improvement of fungal disease identification and management: combined health systems and public health approaches. Lancet Infect Dis 2017;17:e412-e9
  4. Bongomin F, Gago S, Oladele RO, Denning DW. Global and multi-national prevalence of fungal diseases-estimate precision. J Fungi (Basel) 2017;3
  5. Hilmioglu-Polat S, Seyedmousavi S, Ilkit M, Hedayati MT, Inci R, Tumbay E, et al. Estimated burden of serious human fungal diseases in Turkey. Mycoses 2019;62:22-31
  6. Wickes BL, Romanelli AM. Diagnostic mycology: Xtreme challenges. J Clin Microbiol 2020;58
  7. Walsh TH, Hayden TH, Larone DH. Larone’s Medically Important Fungi: A Guide to Identification. 6th ed. Washington DC: ASM Press, 2018
  8. Tortorano AM, Richardson M, Roilides E, van Diepeningen A, Caira M, Munoz P, et al. ESCMID and ECMM joint guidelines on diagnosis and management of hyalohyphomycosis: Fusarium spp., Scedosporium spp. and others. Clin Microbiol Infect 2014;20(Suppl 3):27-46
  9. Guarner J, Brandt ME. Histopathologic diagnosis of fungal infections in the 21st century. Clin Microbiol Rev 2011;24:247-80
  10. Cuenca-Estrella M, Verweij PE, Arendrup MC, Arikan-Akdagli S, Bille J, Donnelly JP, et al. ESCMID* guideline for the diagnosis and management of Candida diseases 2012: diagnostic procedures. Clin Microbiol Infect 2012;18(Suppl 7):9-18
  11. Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, et al. Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline. Clin Microbiol Infect 2018;24(Suppl 1):e1-e38
  12. Karcioglu O, Dogan R, Uzun O, Tokat F, Gulmez D, Arikan- Akdagli S, et al. A rare presentation of pulmonary aspergillosis: Bronchial stump aspergillosis. J Bronchology Interv Pulmonol 2020;27:e28-e33
  13. Petrucelli MF, Abreu MH, Cantelli BAM, Segura GG, Nishimura FG, Bitencourt TA, et al. Epidemiology and diagnostic perspectives of dermatophytoses. J Fungi (Basel) 2020;6
  14. Moodley B, Tempia S, Frean, JA. Comparison of quantitative real-time PCR and direct immunofluorescence for the detection of Pneumocystis jirovecii. PLoS One 2017;12:e0180589
  15. Pitarch A, Nombela C, Gil C. Diagnosis of invasive