AI Summary & Key Takeaways
AI InsightSera Zn levels for control groups and the patients were 62.00±7.86 µg/100 mL and 68.67 ± 5.84 µg/100 mL respectively, and there was no significant statistical difference between them (p>0,05).
📌 3 Key Takeaways
Abstract
Tuberculosis (TB) is a chronic infection caused by Mycobacterium tuberculosis (MTB), an intracellular pathogen. In this study, levels of copper (Cu) and zinc (Zn), which are serum transition metals, were studied in the host infected with Mycobacterium tuberculosis. Twenty one healthy subjects (mean age = 35, 77±10, 54) (n = 21) negative polymerase chain reaction (PCR) and acid fast bacilli (ARB) in sputum for tuberculosis, and 19 non-treated patients with TB (n=19) (mean age = 31, 85±7,39) diagnosed by PCR and ARB etc. in sputum, and pleural, bronchial alveolar lavage and aspiration fluid were subjected to the study. Cu and Zn levels in serum were measured by atomic absorption spectrophotometer. Cu levels in sera for the control groups and the patients were found to be 72.05±7.04 µg/100 mL and 68.33±4.66 µg/100 mL respectively, and statically there was a significant difference between them (p<0,05). Sera Zn levels for control groups and the patients were 62.00±7.86 µg/100 mL and 68.67 ± 5.84 µg/100 mL respectively, and there was no significant statistical difference between them (p>0,05).
Özet
Tüberküloz (TB), intrasellüler bir patojen olan Mikobakterium tuberkülozis (MTB) tarafından oluşturulan kronik bir infeksiyondur. Bu çalışmada konakçıda Mikobakterium tüberkülozis enfeksiyonunda, serum geçiş metallerinden olan bakır (Cu) ve çinko (Zn) düzeyleri araştırıldı. Çalışma, TB tanısı için balgamda asit fast basil (ARB) ve "polymerase chain reactionu" (PCR) negatif olan sağlıklı 21 (n=21) kişiden (yaş ort; 35, 77±10,54) oluşan kontrol grubu ve balgam, plevra, bronşial alveolar lavaj ve aspirasyon sıvısında PCR, ARB vb yöntemlerle tanısı konulmuş ve henüz tedaviye başlanmamış olan 19 (n=19) (yaş ort; 31,85±7,39) kişiden oluşan hasta grubu ile yapıldı. Serumdaki Cu ve Zn düzeyleri, atomik absorbsiyon spektrofotometresi ile ölçüldü. Hasta ve kontrol gruplarının serum Cu düzeyleri sırasıyla 72.05±7.04 µg/100 mL ve 68.33±4.66 µg/100 mL olarak bulundu ve aralarında istatistiksel olarak anlamlı farklılık saptandı (p 0,05).