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Journals / Ege Tıp Dergisi / 2004 / Cilt: 43 - Sayı: 2

Çocuk böbrek allograflarında erken akut rejeksiyon ile interlökin-6-174 C alleli ilişkilidir

The interleukin-6-174 C allel is associated with early acute rejection in pediatric kidney allografts

Caner KABASAKAL
Afig BERDELİ
Sevgi MİR
Pages
83–85
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Our results imply a higher risk of early acute rejection in carriers of -174 C allel compared to non-carriers, and the relative risk of early acute rejection is 4.3 fold higher in IL-6 -174 C allel carrriers.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:lnterleukin-6 (IL-6) is a pleiotropic cytokine with a central role in inflammation, host defense and tissue injury.
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Key Findings & Data:Although it is considered as predominantly proinflammatory cytokine; recently, IL-6 has been recognized as having additional immunosuppressive properties.
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Conclusion & Impact:Our results imply a higher risk of early acute rejection in carriers of -174 C allel compared to non-carriers, and the relative risk of early acute rejection is 4.3 fold higher in IL-6 -174 C allel carrriers.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Böbrek nakli · İnterlökin-6 · Böbrek

Abstract

lnterleukin-6 (IL-6) is a pleiotropic cytokine with a central role in inflammation, host defense and tissue injury. Although it is considered as predominantly proinflammatory cytokine; recently, IL-6 has been recognized as having additional immunosuppressive properties. In this study, we investigated the impact of IL-6 -174 G/C promoter genotype on acute rejection in 14 patients out of 55 kidney recipients. In 14 acute rejection presenting patients, early acute rejection (within first 3 months) was found significantly frequent in -174 C allel carriers, compared to non-carriers (33.3% vs 10.3% p<0.05). Our results imply a higher risk of early acute rejection in carriers of -174 C allel compared to non-carriers, and the relative risk of early acute rejection is 4.3 fold higher in IL-6 -174 C allel carrriers.

Özet

lnterlökin-6 (IL-6) inflamasyon, konakçı savunması ve doku hasarında önemli rol oynayan çok işlevli bir sitokindir. Daha çok proinflamatuar sitokin olarak kabul edilmekle birlikte, son zamanlarda IL-6'nm immunsupressif rolü de saptanmıştır. Bu çalışmada, IL-6 -174 G/C promoter genotipinin, 55 böbrek nakli hastasından 14'ünde görülen akut rejeksiyona etkisi incelenmiştir. Akut rejeksiyon gözlenen 14 hastada, erken (ilk 3 ay içinde) akut rejeksiyon görülmesinin -174 C allel taşıyanlarda, taşımayanlara oranla anlamlı şekilde daha fazla olduğu bulunmuştur (%33,3 ile %10,3 p<0.05). Bu çalışmanın sonuçları, -174 C allel taşıyanlarda erken akut rejeksiyon riskinin daha fazla olduğu ve taşımayanlara oranla 4,3 kat daha fazla rölatif risk altında olduğunu düşündürmektedir.

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Cite This Article

KABASAKAL, C., BERDELİ, A., MİR, S. (2004). Çocuk böbrek allograflarında erken akut rejeksiyon ile interlökin-6-174 C alleli ilişkilidir. Ege Tıp Dergisi, Cilt: 43 - Sayı: 2, 83–85. https://ajindex.com/articles/223020

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