This study was performed to determine the prevalence hepatitis B surfage antigen other hepatitis B markers anti HCV antibodies the variations during the course of haemodialysis and immun response to a recombinant hepatitis B vaccine in children with chronic renal failure on haemodialysis nbsp; 54 patients 26 males and 28 females median age 12 1±2 7 years range 5 16 years treated with haemodialysis for median of 12 9±13 9 months were studied All hepatitis markers were detected in serum by an enzyme immunassey in the beginning of haemodialysis and 3 6 months interval during the period of haemodialysis In the beginning of haemodialysis 5 of the patients 9 2 were HBsAg positive 17 31 5 HBsAg negative anti HBs positive and or anti HBc positive nbsp; 33 patients were evaluated for anti HCV antibodies and 9 of these patients 30 3 were anti HCV positive One of the seronegative patients treated with haemodialysis for three years developed hepatitis B infection but none of the seronegative patients developed hepatitis C infection 8 patients with negative hepatitis B markers were immunized with three doses of 20 micrograms of hepatitis B vaccine administered at monthly intervals 5 patients 62 5 developed seroconversion after three vaccinations Key words: Hemodialysis Hepatitis B Hepatitis C Hepatitis B Vaccine
📌 3 Key Takeaways
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Objective & Hypothesis:This study was performed to determine the prevalence hepatitis B surfage antigen other hepatitis B markers anti HCV antibodies the variations during the course of haemodialysis and immun response to a recombinant hepatitis B vaccine in children with chronic renal failure on haemodialysis nbsp; 54 patients 26 males and 28 females median age 12 1±2 7 years range 5 16 years treated with haemodialysis for median of 12 9±13 9 months were studied All hepatitis markers were detected in serum by an enzyme immunassey in the beginning of haemodialysis and 3 6 months interval during the period of haemodialysis In the beginning of haemodialysis 5 of the patients 9 2 were HBsAg positive 17 31 5 HBsAg negative anti HBs positive and or anti HBc positive nbsp; 33 patients were evaluated for anti HCV antibodies and 9 of these patients 30 3 were anti HCV positive One of the seronegative patients treated with haemodialysis for three years developed hepatitis B infection but none of the seronegative patients developed hepatitis C infection 8 patients with negative hepatitis B markers were immunized with three doses of 20 micrograms of hepatitis B vaccine administered at monthly intervals 5 patients 62 5 developed seroconversion after three vaccinations Key words: Hemodialysis Hepatitis B Hepatitis C Hepatitis B Vaccine
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Key Findings & Data:This study was performed to determine the prevalence hepatitis B surfage antigen other hepatitis B markers anti HCV antibodies the variations during the course of haemodialysis and immun response to a recombinant hepatitis B vaccine in children with chronic renal failure on haemodialysis nbsp; 54 patients 26 males and 28 females median age 12 1±2 7 years range 5 16 years treated with haemodialysis for median of 12 9±13 9 months were studied All hepatitis markers were detected in serum by an enzyme immunassey in the beginning of haemodialysis and 3 6 months interval during the period of haemodialysis In the beginning of haemodialysis 5 of the patients 9 2 were HBsAg positive 17 31 5 HBsAg negative anti HBs positive and or anti HBc positive nbsp; 33 patients were evaluated for anti HCV antibodies and 9 of these patients 30 3 were anti HCV positive One of the seronegative patients treated with haemodialysis for three years developed hepatitis B infection but none of the seronegative patients developed hepatitis C infection 8 patients with negative hepatitis B markers were immunized with three doses of 20 micrograms of hepatitis B vaccine administered at monthly intervals 5 patients 62 5 developed seroconversion after three vaccinations Key words: Hemodialysis Hepatitis B Hepatitis C Hepatitis B Vaccine
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Conclusion & Impact:This study was performed to determine the prevalence hepatitis B surfage antigen other hepatitis B markers anti HCV antibodies the variations during the course of haemodialysis and immun response to a recombinant hepatitis B vaccine in children with chronic renal failure on haemodialysis nbsp; 54 patients 26 males and 28 females median age 12 1±2 7 years range 5 16 years treated with haemodialysis for median of 12 9±13 9 months were studied All hepatitis markers were detected in serum by an enzyme immunassey in the beginning of haemodialysis and 3 6 months interval during the period of haemodialysis In the beginning of haemodialysis 5 of the patients 9 2 were HBsAg positive 17 31 5 HBsAg negative anti HBs positive and or anti HBc positive nbsp; 33 patients were evaluated for anti HCV antibodies and 9 of these patients 30 3 were anti HCV positive One of the seronegative patients treated with haemodialysis for three years developed hepatitis B infection but none of the seronegative patients developed hepatitis C infection 8 patients with negative hepatitis B markers were immunized with three doses of 20 micrograms of hepatitis B vaccine administered at monthly intervals 5 patients 62 5 developed seroconversion after three vaccinations Key words: Hemodialysis Hepatitis B Hepatitis C Hepatitis B Vaccine
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
This study was performed to determine the prevalence hepatitis B surfage antigen other hepatitis B markers anti HCV antibodies the variations during the course of haemodialysis and immun response to a recombinant hepatitis B vaccine in children with chronic renal failure on haemodialysis nbsp; 54 patients 26 males and 28 females median age 12 1±2 7 years range 5 16 years treated with haemodialysis for median of 12 9±13 9 months were studied All hepatitis markers were detected in serum by an enzyme immunassey in the beginning of haemodialysis and 3 6 months interval during the period of haemodialysis In the beginning of haemodialysis 5 of the patients 9 2 were HBsAg positive 17 31 5 HBsAg negative anti HBs positive and or anti HBc positive nbsp; 33 patients were evaluated for anti HCV antibodies and 9 of these patients 30 3 were anti HCV positive One of the seronegative patients treated with haemodialysis for three years developed hepatitis B infection but none of the seronegative patients developed hepatitis C infection 8 patients with negative hepatitis B markers were immunized with three doses of 20 micrograms of hepatitis B vaccine administered at monthly intervals 5 patients 62 5 developed seroconversion after three vaccinations Key words: Hemodialysis Hepatitis B Hepatitis C Hepatitis B Vaccine
Özet
Bu çalışmada kronik hemodiyaliz KHD programına alınan çocuk olgularında HbsAg ve anti HCV sıklığının belirlenmesi izlem sırasında rastlanılan değişikliklerin sergilenmesi ve hepatit B aşı uygulamasının sonuçlarının bildirilmesi amaçlanmıştır 28 kız ve 26 erkek olmak üzere toplam 54 olgu değerlendirilmiştir Yaşları 5 16 yaş yaş ortalaması 12 1±2 7 yıldır Ortalama HD süresi ise 12 9±13 9 aydır Olguların HD başlangıcında ve 3 6 ayda 1 kez tüm hepatit göstergeleri Elisa ile değerlendirilmiştir Başlangıçta 5 olguda 9 2 HbsAg liği 17 olguda 31 5 HbsAg anti Hbs ve veya anti Hbc liği saptanmıştır Hepatit C için değerlendirilen 33 olgudan 9 olguda 30 3 anti HCV bulunmuştur İzlem sırasında ise enfeksiyona duyarlı olguların hiçbirisinde hepatit C enfeksiyonu bulaşması görülmemişken 3 senelik HD alan bir olguda hepatit B enfeksiyonu bulaşması saptanmıştır Hepatit B antijen ve antikoru olan 8 olguya rekombinan 20 mikrogram dozda hepatit B aşısı 0 1 ve 2nd aylarda yapılmış ve 5 olguda 62 5 yeterli immün cevap elde edilmiştir Anahtar kelimeler: Hemodiyaliz Hepatit B Hepatit C Hepatit B Aşısı
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Cite This Article
Bak, M., Aksu, N., Kabasakal, C., Cura, A. (1993). Hepatitis B and Hepatitis C Infections and Hepatitis B Vaccination in Pediatric Patients on Haemodialysis. Türk Pediatri Arşivi, Cilt: 28 Sayı: 4, 1–1. https://ajindex.com/articles/1012501