Journals / Ege Tıp Dergisi / 2019 / Cilt: 58 - Sayı: 3

Coronary artery calcium score is associated with red blood cell distribution width and mean platelet volume

Koroner arter kalsiyum skoru kırmızı kan hücresi dağılım genişliği ve ortalama trombosit hacmi ile ilişkilidir

Pages
222–228
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Because several factors may affect these parameters further prospective studies are needed to confirm our results.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: In this paper, it is aimed to investigate red blood cell distribution width (RDW), mean platelet volume (MPV) and coronary artery calcium scores (CACS) in patients with and without coronary artery disease (CAD) detected by coronary computed tomography angiography (CCTA).
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Key Findings & Data:Materials and Methods: Clinical records of 172 patients who underwent CCTA due to the presence of angina-like symptoms were retrospectively investigated.
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Conclusion & Impact:Because several factors may affect these parameters further prospective studies are needed to confirm our results.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: In this paper, it is aimed to investigate red blood cell distribution width (RDW), mean platelet volume (MPV) and coronary artery calcium scores (CACS) in patients with and without coronary artery disease (CAD) detected by coronary computed tomography angiography (CCTA). Materials and Methods: Clinical records of 172 patients who underwent CCTA due to the presence of angina-like symptoms were retrospectively investigated. Clinical characteristics, risk factors for CAD, CACS and biochemical parameters including RDW and MPV were recorded. Results: Mean MPV (7.95 ±1.57 fL vs. 7.12±1.26 fL, p<0.001) and RDW (15.36±1.15% vs 14.37±2.01%; p<0.001) levels were significantly higher in patients with CAD (n=85) than in those with normal coronary arteries (n=87). CACS is positively corralated with age (r=0.339, p<0.001), fasting glucose (r=0.223, p=0.003), C-reactive protein (r=0.294, p<0.001), RDW (r=0.157, p=0.04) and MPV (r=0.221, p=0.004). On multivariate logistic regression analysis, CACS [odds ratio (OR): 1.005; 95% confidence interval (CI): 1.002-1.008; p=0.001] and MPV [OR: 1.410; 95% CI: 1.069-1.860; p=0.015] were shown to be one of the independent predictors for CAD detected by CCTA. Conclusion: RDW and MPV were increased in patients with CAD detected by CCTA. These parameters were possitively corralated with CACS which is a well-known indicator for CAD. Because several factors may affect these parameters further prospective studies are needed to confirm our results.

Özet

Amaç: Bu çalışmada, koroner bilgisayarlı tomografik anjiyografi (KBTA) ile saptanan koroner arter hastalığı (KAH) ve koroner arter kalsiyum skorunun (KAKS) kırmızı kan hücresi dağılım genişliği (RDW) ve ortalama trombosit hacmi (MPV) arasındaki ilişkinin değerlendirilmesi amaçlandı. Gereç ve Yöntem: Anjina veya benzeri semptomlar nedeniyle 64 kesitli KBTA uygulanan 172 hastanın tıbbi kayıtları geriye dönük olarak incelendi. Hastaların klinik özellikleri, risk faktörleri, KAKS’ı da içeren KBTA sonuçları, RDW, MPV değerlerini de içeren biyokimyasal ve hematolojik parametreleri kaydedildi. Bulgular: Çalışma popülasyonu KBTA sonuçlarına göre KAH (n=85) ve normal koroner arter (NKA) (n=87) olmak üzere iki gruba ayrıldı. Ortalama RDW (%15,36±1,15’e karşı %14,37±2,01; p<0,001) ve MPV (7,95 ± 1,57 fL’e karşı 7,12±1,26 fL, p<0,001) seviyeleri KAH grubunda NKA grubuna göre anlamlı olarak yüksek saptandı. KAKS ile yaş (r=0,339, p<0,001), açlık kan şekeri (r=0,223, p=0,003), C-reaktif protein (r=0,294, p<0,001), RDW (r=0,157, p=0,04) ve MPV (r=0,221, p=0,004) arasında pozitif korelasyon saptandı. Yapılan çok değişkenli lojistik regresyon analizinde KAKS [odds oranı (OR): 1,005; %95 güven aralığı (CI): 1,002- 1,008; p=0,001] ve MPV [OR: 1,410; %95 CI: 1,069-1.860; p=0.015] KBTA ile saptanan KAH’ın bağımsız risk faktörleri arasında saptandı. Sonuç: RDW ve MPV KAH grubunda anlamlı olarak daha yüksek saptanmıştır. Koroner aterosklerozun iyi bir göstergesi olan KAKS ile bu parametreler arasında pozitif bir korelasyon gösterilmiştir. MPV ve RDW düzeylerinin çok çeşitli faktörlerden etkilenebileceği de düşünülürse bu konuda geniş kapsamlı ileri prospektif çalışmalara ihtiyaç duyulmaktadır.

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Cite This Article

ALTIN, C., YILMAZ, M., GEZMİŞ, E., MÜDERRİSOĞLU, H. (2019). Coronary artery calcium score is associated with red blood cell distribution width and mean platelet volume. Ege Tıp Dergisi, Cilt: 58 - Sayı: 3, 222–228. https://ajindex.com/articles/222689

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