Journals / İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi / 2012 / Cilt: 2 - Sayı: 2

Neurodevelopmental follow-up results in very low birth weight premature infants and influential factors

Çok düşük doğum ağırlıklı prematüre bebeklerde nörogelişimsel izlem sonuçları ve etkileyen faktörler

Pages
94–101
DOI
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CONCLUSION: Clinical sepsis, surfactant need, monitorization with mechanical ventilation, bronc- hopulmonary dysplasia and severe intraventricular hemorrhage are risk factors that influence neurodevelopmental prognosis in very low birth weight preterm infants.

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Objective & Hypothesis:OBJECTIVE: To investigate the frequency of long-term neurodevelopmental disorders and evalua- te risk factors it was aimed for growth, and developmental retardation in very low birth weight infants who were discharged from Neonatal Intensive Care Unit.
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Key Findings & Data:METHODS: Sixty-one preterm infants with birth weights under 1500 grams hospitalized in Neonatal intensive Care Units at Izmir Tepecik Teaching and Research Hospital between January and December 2007 were retrospectively evaluated.
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Conclusion & Impact:CONCLUSION: Clinical sepsis, surfactant need, monitorization with mechanical ventilation, bronc- hopulmonary dysplasia and severe intraventricular hemorrhage are risk factors that influence neurodevelopmental prognosis in very low birth weight preterm infants.
🔬Design:Research Article
📍Scope:2007 Verileri
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: To investigate the frequency of long-term neurodevelopmental disorders and evalua- te risk factors it was aimed for growth, and developmental retardation in very low birth weight infants who were discharged from Neonatal Intensive Care Unit. METHODS: Sixty-one preterm infants with birth weights under 1500 grams hospitalized in Neonatal intensive Care Units at Izmir Tepecik Teaching and Research Hospital between January and December 2007 were retrospectively evaluated. Demographical features, complica- tions encountered during hospitalization and clinical risk factors affecting growth retardation were recorded. Infants were examined for growth and neurological development corrected for 18 and 24 months of age and Denver Developmental Screening Test was used for determining neu- rological development. RESULTS: The main findings were as follows: 45.9% of the cases was male, the mean gestational age was 29 ± 2.1 weeks and mean birth weight was 1205 ± 214 grams. Risk factors that influenced the neurodevelopmental prognosis were respiratory distress syndrome (80.3%), clinical sepsis (50.8%), monitorization with mechanical ventilation (39.3%) and need for surfactant (37.7%). Denver Developmental Screening test found smaller head circumference and height of infants with growth retardation at 18., and 24. months of age relative to their peers with normal neuro- developmental status.The rates of clinical sepsis, surfactant administration, mechanical ventila- tion, bronchopulmonary dysplasia and intraventricular hemorrhage were statistically significant height in very low birth weight infants with abnormal neurodevelopment corrected for 24 months of age (p<0,05). These infants also showed growth retardation both at 18 and 24 months of age (p<0,05). CONCLUSION: Clinical sepsis, surfactant need, monitorization with mechanical ventilation, bronc- hopulmonary dysplasia and severe intraventricular hemorrhage are risk factors that influence neurodevelopmental prognosis in very low birth weight preterm infants.

Özet

AMAÇ: Yenidogan Yoğun Bakım Ünitesi'nden taburcu olan çok düşük doğum ağırlıklı preterm bebeklerin uzun dönemdeki nörogelişimsel bozukluk sıklığını araştırmak, büyüme ve gelişme geriliğine neden olan risk faktörlerini değerlendirmek amaçlanmıştır. YÖNTEMLER: Ocak - Aralık 2007 arasında İzmir Tepecik Eğitim ve Araştırma Hastanesi, Yenidogan Yoğun Bakım Ünitesi'nde yatırılan doğum ağırlığı 1500 gram ve altındaki 61 preterm retrospektif olarak incelendi. Olguların demografik özellikleri, yatış sırasında gözlenen komplikasyonlar, nörogelişimsel bozukluk ve büyüme geriliğine etki eden klinik risk faktörleri kaydedildi. Preterm bebekler duzeltilmiş 18. ve 24. ayda ağırlık, boy, baş çevresi, nörolojik muayene ve Denver Gelişimsel Tarama Testi ile büyüme ve nörolojik gelişim açısından değerlendirildi. BULGULAR: Olguların %45,9'u erkek, ortalama gebelik yaşı 29 ± 2,1 hafta, ortalama doğum ağırlığı 1205 ± 214 gramdı. Nörogelişimsel prognoza etki eden risk faktörleri sıklık sırasına göre %80,3 respiratuar distres sendromu, %50,8 klinik sepsis, %39,3 mekanik ventilatör ile izlem, %37,7 surfaktan gereksinimi olarak saptandı. Denver Gelişimsel Tarama Testi 18. ve 24. ayda anormal olan bebeklerin boy ve baş çevre ölçümleri, nörogelişimi normal saptanan gruba göre daha düşük bulundu (p<0,05). Düzeltilmiş 24. ayda anormal nörogelişimsel bozukluk gösteren olgularda klinik sepsis, surfaktan gereksinimi, mekanik ventilator ile izlem, ağır intrakranial kanama, periventrikuler lökomalazi ve bronkopulmoner displazi varlığı istatiksel olarak anlamlı düzeyde fazla saptandı (p<0,05). SONUÇ: Çok düşük doğum ağırlıklı pretermlerde sepsis, mekanik ventilator ile izlem, surfaktan gereksinimi, bronkopulmoner displazi, ağır intraventriküler kanama ve periventriküler lökomalazi varlığı nörogelişimsel pronozu olumsuz etkileyen risk faktörleridir.

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Cite This Article

SÜTÇÜOĞLU, S., DİKERLER, A., HALICIOĞLU, O., İNAL, M. A., ÖZTÜRK, C., AŞIK, S. A., ÖZER, E. (2012). Neurodevelopmental follow-up results in very low birth weight premature infants and influential factors. İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi, Cilt: 2 - Sayı: 2, 94–101. https://ajindex.com/articles/219747

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