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Journals / Glokom Katarakt / 2012 / Cilt: 7 - Sayı: 4

Experimental models of glaucoma

Deneysel glokom modelleri

Burçin Kepez YILDIZ
METİN ÜNLÜ
Zeynep AKTAŞ
Pages
201–208
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this study, experimental glaucoma models have been reviewed.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Glaucoma is a group of disorders which lead to progressive and irreversible visual functional loss.
📊
Key Findings & Data:Experimental models are frequently used in order to understand the pathophysiology of glaucoma and develop new treatment modalities.
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Conclusion & Impact:In this study, experimental glaucoma models have been reviewed.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Glaucoma is a group of disorders which lead to progressive and irreversible visual functional loss. Experimental models are frequently used in order to understand the pathophysiology of glaucoma and develop new treatment modalities. In experimental studies, various animal models with spontaneous or induced glaucoma are used. In this study, experimental glaucoma models have been reviewed.

Özet

Glokom ilerleyici ve geri dönüşümsüz görme fonksiyon kaybı ile seyreden bir hastalık grubudur. Glokomun patofizyolojisini anlamak, tedavi modaliteleri geliştirmek için deneysel modeller sıklıkla kullanılmaktadır. Deneysel çalışmalarda glokomun spontan olarak geliştiği hayvanların yanı sıra, indüklenerek hastalık oluşturulan pek çok model kullanılmaktadır. Bu çalışmada deneysel glokom modelleri gözden geçirilmektedir.

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Cite This Article

YILDIZ, B. K., ÜNLÜ, M., AKTAŞ, Z. (2012). Experimental models of glaucoma. Glokom Katarakt, Cilt: 7 - Sayı: 4, 201–208. https://ajindex.com/articles/216189

References (18)

  1. Weinreb RN, Khaw PT. Primary open-angle glaucoma. Lancet 2004;363:1711-20
  2. Tomarev SI. Animal models of glaucoma. Encyclopedia of the Eye, 1st Edition (Dartt. D. A., Beshrse. J. C. and Dana, R., Eds.). 2010 vol.1:106-11
  3. Johnson T, Tomarev S. Rodent models of glaucoma, Brain Research Bulletin 2010;81: 349-58
  4. Rasmussen CA, Kaufman PL. Primate glaucoma models, journal of glaucoma 2005;14: 311-4
  5. Brooks DE. Glaucoma in the dog and cat. Veterinary Clinics of North America-Small Animal Practice, 1990;20:775-97
  6. Ederra JR, Garcia M, Hernandez M et al. The pig Eye as a novel model of Glaucoma, Experimental Eye Research 2005;81:561-9
  7. Pang IH, Clark AF. Rodent Models for Glaucoma Retinopathy and Optic Neuropathy, Journal of Glaucoma 2007;16:483-505
  8. Li ZY, Wong F, Chang JH et al. Rhodopsin transgenic pigs as a model for human retinitis pigmentosa. Invest Ophthalmol Vis. Sci 1998;39:808-19
  9. Ederra JR, Verkman AS. Mouse model of sustained elevation in intraocular pressure produced by episcleral vein occlusion. Experimental Eye Research 2006;82:879-84
  10. Vecino E. Animal Models in the study of the Glaucoma: Past, Present and Future, Arch Soc Esp Oftalmol 2008;83:517-20
  11. Wang RF, Schumer RA, Serle JB et al. A comparison of argon laser and diode laser photocoagulation of the trabecular meshwork to produce the glaucoma monkey model. J Glaucoma 1998;7:45-9
  12. Weber AJ, Zelenak D. Experimental glaucoma in the primate induced by latex microspheres. J Neurosci Methods 2001;111:39-48
  13. Kaufman PL, Lütjen-Drecoll E, Hubbard WC, et al. Obstruction of aqueous humor outflow by cross-linked polyacrylamide microgels in bovine, monkey and human eyes. Ophthalmology 1994;101:1672-9
  14. Rauhut D, Rohen JW. Electron microscopic study of the trabecular meshwork in alpha-chymotrypsin glaucoma. Albrecht Von Graefes Arch Klin Exp Ophthalmol 1972;184:29-41
  15. Fingert JH, Clark AF, Craig JE, et al. Evaluation of the myocilin (MYOC) glaucoma gene in monkey and human steroid-induced ocular hypertension. Invest Ophthalmol Vis Sci 2001;42:145-52
  16. Weber A, Viswanathan S. The primate model of experimental glaucoma, mechanisms of the glaucomas. Ophthalmology Research 2008;551-77
  17. Quigley HA and Addicks EM. Chronic experimental glaucoma in primates. II.Effect of extended intraocular pressure elevation on optic nerve head and axonal transport. Invest. Ophthalmol Vis. Sci 1980;19:137-52
  18. Orgul S, Cioffi GA, Bacon DR, et al. An endothelin-1-induce