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Journals / Turkish Journal of Chemistry / 2020 / Cilt: 44 - Sayı: 4

Preparation, structure elucidation, and antioxidant activity of new bis(thiosemicarbazone) derivatives

Hasan YAKAN
Pages
1085–1099
Publication Date
2020-08-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Moreover, this study explained the structure-activity relationship of the synthesized molecules with different substituents in radical trapping reactions.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Schiff-base-bearing new bis(thiosemicarbazone) derivatives were prepared from terephthalaldehyde and various thiosemicarbazides.
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Key Findings & Data:FT-IR, H-1 NMR, C-13 NMR, and UV-Vis spectroscopic methods and elemental analysis were used to elucidate the identification of the synthesized molecules.
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Conclusion & Impact:Moreover, this study explained the structure-activity relationship of the synthesized molecules with different substituents in radical trapping reactions.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Thiosemicarbazides · Schiff bases · DPPH

Abstract

Schiff-base-bearing new bis(thiosemicarbazone) derivatives were prepared from terephthalaldehyde and various thiosemicarbazides. FT-IR, H-1 NMR, C-13 NMR, and UV-Vis spectroscopic methods and elemental analysis were used to elucidate the identification of the synthesized molecules. The in vitro antioxidant activity of the synthesized compounds was analysed with the 1,1-diphenyl-2-picryl hydrazyl free-radical-trapping process. The synthesized compounds exhibited lower antioxidant activity than the standard ascorbic acid. IC50 values of the synthesized molecules measured from 3.81 +/- 0.01 to 29.05 +/- 0.11 mu M. Among the synthesized compounds, compound 3 had the best antioxidant activity. Moreover, this study explained the structure-activity relationship of the synthesized molecules with different substituents in radical trapping reactions.

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Cite This Article

YAKAN, H. (2020). Preparation, structure elucidation, and antioxidant activity of new bis(thiosemicarbazone) derivatives. Turkish Journal of Chemistry, Cilt: 44 - Sayı: 4, 1085–1099. https://ajindex.com/articles/214929

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