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Journals / Glokom Katarakt / 2013 / Cilt: 8 - Sayı: 2

The impact of prostaglandin analogs on corneal sensitivity, ocular surface changes and quality of life in glaucoma patients

Glokomlu olgularda prostaglandin analoglarının korneal sensitivite, oküler yüzey değişiklikleri ve hayat kalitesi üzerine etkisi

Zeynep AKTAŞ
Demet YOLCU
Mehmet Özgür ÇUBUK
CELAL MURAT HASANREİSOĞLU
Berati HASANREİSOĞLU
Pages
83–88
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, this finding might also be related to the emotional status of the glaucoma patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: To evaluate the impact of prostaglandin analogs (PGA) on corneal sensitivity, ocular surface changes and the quality of life (QOL) in glaucoma patients.
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Key Findings & Data:Materials and Methods: 51 primary open angle glaucoma patients were included in the study.
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Conclusion & Impact:However, this finding might also be related to the emotional status of the glaucoma patients.
🔬Design:Survey & Empirical Study
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: To evaluate the impact of prostaglandin analogs (PGA) on corneal sensitivity, ocular surface changes and the quality of life (QOL) in glaucoma patients. Materials and Methods: 51 primary open angle glaucoma patients were included in the study. Patients were divided into three groups according to types of PGA used (G1: latanoprost, G2: travoprost, G3: bimatoprost group). 20 healty subjects were taken as healthy controls (G4). Each patient completed an Ocular Surface Disease Index (OSDI) questionnaire and objective ocular surface tests were applied (Schirmer test (mm), central corneal mechanic sensitivity (CCMS), tear break- up time (TBUT), corneal and conjunctival fluorescein staining). Kruskal-Wallis and Mann-Whitney U tests were used to compare differences among groups. Results: OSDI scores were comparable in G1, G2 and G3 and these were significantly different from that of controls (G4). 40% of G1, 68% of G2 and 73% of G3 had mild to moderate OSDI scores but it was normal in G4. TBUT, Schirmer’s test and corneal and conjunctival staining scores were comparable among groups. Corneal sensitivity was also comparable among all treatment groups but it was significantly reduced in travoprost group (G2) when compared with that of controls (G4). Conclusions: All PGAs have similar effects on ocular surface parameters. On the other hand, they seem to effect the QOL significantly compared with that of healthy controls. However, this finding might also be related to the emotional status of the glaucoma patients.

Özet

Amaç: Glokom olgularında prostaglandin analoğu (PGA) kullanımının korneal sensitivite, oküler yüzey değişiklikleri ve hayat kalitesi üzerine olan etkisininin değerlendirilmesidir. Gereç ve Yöntem: Çalışmaya 51 primer açık açılı glokom olgusu dahil edildi. Olgular kullandıkları PGA türüne göre 3 grup altında sınıflandırıldı. (G1: Latanoprost, G2: Travoprost, G3: Bimatoprost). 20 sağlıklı olgu kontrol grubu olarak alındı (G4: kontrol). Her olgu için oküler yüzey hastalık indeksi (OSDI) formu dolduruldu ve objektif oküler yüzey testleri uygu- landı (Schirmer’s test, santral korneal mekanik sensitivite (CCMS) tayini, gözyaşı kırılma zamanı (TBUT) ve fluoroscein ile konjonktival ve korneal boyanma paterni). Kruskal-Wallis ve Mann-Whitney U testleri gruplar arasındaki farkları tespit etmek için kullanıldı. Bulgular: OSDI skorları G1,G2,G3 tedavi grupları arasında benzerdi ancak bu değerler kontrol grubuna (G4) göre anlamlı derecede farklıydı. G1 grubunun %40’ı, G2 grubunun %68’i ve G3 grubunun %73’ü hafif-orta derecede etkilenme gösterirken G4’de OSDI sonuçları normaldi. TBUT, Schirmer test sonuçları, korneal ve konjonktival boyanma oranları tüm gruplarda benzerdi. Korneal sensitivite üç tedavi grubunda benzerken kontrol grubu ile kıyaslandığında travoprost grubunda (G2) anlamlı derecede azalmıştı. Sonuç: Topikal PGA tiplerinin objektif yüzey parametreleri üzerine olan etkileri benzerdir. Bununla birlikte, sağlıklı kontrollerle ile karşılaştırıldığında, hayat kalitesini anlamlı derecede etkilediği görülmektedir. Ancak bu bulgu glokomlu olgularda emosyonel durum ile de ilişkili olabilir.

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Cite This Article

AKTAŞ, Z., YOLCU, D., ÇUBUK, M. Ö., HASANREİSOĞLU, C. M., HASANREİSOĞLU, B. (2013). The impact of prostaglandin analogs on corneal sensitivity, ocular surface changes and quality of life in glaucoma patients. Glokom Katarakt, Cilt: 8 - Sayı: 2, 83–88. https://ajindex.com/articles/214233

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