SavedAdd your journal

Journals / Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi / 2002 / Cilt: 7 - Sayı: 3

Evaluation of febrile neutropenic attacks

Febril nötropenik atakların değerlendirilmesi

Nebahat DİKİCİ
Onur URAL
Pages
185–190
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Success in treatment was achieved at 61 (88.4%) patients, 8 (I 1.6%) patients died.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study, origin of infection, therapeutic protocols, success and mortality rate of therapy were investigated in febrile neutropenic cases.
📊
Key Findings & Data:Eighty-two febrile neutropenic attacks in 67 patients (42 male, 25 female) between age 2-82 years were evaluated in this study.
💡
Conclusion & Impact:Success in treatment was achieved at 61 (88.4%) patients, 8 (I 1.6%) patients died.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Nötropeni · İleriye dönük çalışma · Tedavi sonucu

Abstract

In this study, origin of infection, therapeutic protocols, success and mortality rate of therapy were investigated in febrile neutropenic cases. Eighty-two febrile neutropenic attacks in 67 patients (42 male, 25 female) between age 2-82 years were evaluated in this study. Forty-one of the patients were diagnosed as leukemia, 9 as lymphoma, 8 as other hematological malignancies. No hematological malignancies were found at 9 patients. At the end of the examinations, microbiologically documented infection was reported in 35 (42.7%) patients, clinically defined infection was reported in 30 (36.6%), and fever of unknown origin was reported in 17 (20.7%) patients. There was no statistically significant difference between absolute neutrophil count and aetiology of fever (p> 0.05). 75.6% of patients were treated with combined therapy, 14.6% of patients with monotherapy and 9.8% of them were treated with different therapies. Success in treatment was achieved at 61 (88.4%) patients, 8 (I 1.6%) patients died.

Özet

Bu çalışmada, ateşli nötrbpenik olgularda infeksiyon odakları, uygulanan tedavi rejimleri, tedavide başarı oranı ve mortalite oranı araştırıldı. Çalışmamızda, toplam 67 hastada gözlenen 82 ateşli nötropenik atak değerlendirildi. Olguların 41'i lösemi, 9'u lenfoma, 8'i diğer hematolojik malignitelere sahipti ve 9'unda herhangi bir hematolojik malignité bulunmuyordu. Olgularda yapılan incelemeler sonucunda, 35 (%42.7) hastada mikrobiyolojik olarak dokümante edilen infeksiyon, 30 (%36.6) hastada klinik olarak tespit edilmiş infeksiyon, 17 (%20.7) hastada nedeni saptanamayan ateş tespit edildi. Total nötrofil sayısı ile ateş nedenleri arasında anlamlı bir fark görülmedi (p> 0.05). Olguların %75.6'sına kombine tedavi, %14.6'sına monoterapi, %9.8'ine değişik tedaviler verilmiştir. Olguların 61 (%88.4)'inde tedavide başarı elde edilmiş, 8 (%l l.6)"ı kaybedilmiştir.

🔖

Cite This Article

DİKİCİ, N., URAL, O. (2002). Evaluation of febrile neutropenic attacks. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, Cilt: 7 - Sayı: 3, 185–190. https://ajindex.com/articles/213600

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Koli BS, Brown AE. Changing pattern of infections in the immunocompromised patient with cancer. Hematol Oncol Clin North Am 1993;7:75369
  2. Lazarus HM, Creger RJ, Gerson SL. Infectious emergencies in oncology patients. Semin Oncol 1989;16:543-60
  3. De Pauw BE, Donnelly JP. Infections in the immunocompromised host: General principles. In: Mandell GL,Dolin R, Bennett JE (eds). Principles and Practice of Infectious Diseases. 5^ ed. New York: Churchill Livingsto ne,2000:3079-89
  4. Akova M. Kanser hastalarında bakteriyel infeksiyonlara yaklaşım ve empirik antimikrobiyal tedavi Flora 1998-3:3-13
  5. Vartivarin S, Bodey GP. Infections associated with malignancy. In: Gorbach SL, Bartlett JG, Blacklow (eds). Infectious Diseases. 1st ed. WB Saunders Company, 1992:103539
  6. Hughes WT, Armstrong D, Bodey GP; et at. 1997 Guidelines for the use of antimicrobial agents in neutropenic patients with unexplained fever. Clin Infect Dis 1997;25:551-73
  7. Glauser MP. Neutropenia: Clinical implications and modulation. Intensive Care Med 2000;26:103-10
  8. Aygen B. Febril nötropenik hastalarda empirik antibiyotik tedavisi. Bal Ç, Gür D, Söyletir G, Sümerkan B, Dündar V (editörler). Klinik Laboratuvar Uygulamaları. IV. Antibiyotik Kemoterapi Günleri, İstanbul: Dinç Ofset, 1999:38-50
  9. Saba R, Mamıkoğlu L, Günseren F ve ark. Hematolojik maligniteli hastalarda gelişen febril nötropeni ataklarının değerlendirilmesi. Tümbay E, İnci R, Hilmioglu S (editörler). Klinik Laboratuvar Uygulamaları Yenilikleri. III. Anti-mikrobik Kemoterapi Günleri, İzmir: Ege Üniversitesi Basımevi, 1997:368
  10. Pizzo PA. Emprical therapy and prevention of infection in the immunocompromised host. In: Mandell GL, Dolin R, Bennett JE (eds). Principles and Practice of Infectious Diseases. 5th ed. New York: Churchill Livingstone, 2000:3102-10
  11. Pizzo PA. Management of fever in patients with cancer and treatment-induced neutropenia. N Engl J Med 1993;328:1323-32
  12. Brown AE. Neutropenia, fever and infection. Am J Med 1984;76:421-8
  13. Cnanock SJ, Pizzo PA. Fever in the neutropenic host. Infect Dis Clin North Am 1996; 10:777-93
  14. Lucas KG, Brown AE, Armstrong DA, Chapman D, Heller G. The identification of febrile, neutropenic children with neoplastic disease at low risk for bacteremia and complications of sepsis. Cancer 1996;77:791-8
  15. Jones GR, Konsler GK, Dunaway RP, Pusek NS. Infection risk factors in febrile, neutropenic children and adolescents. Pediatr Hematol Oncol 1996;13:217-29. 16.