SavedAdd your journal

Journals / Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi / 2002 / Cilt: 16 - Sayı: 1

The effects of L-carnitine on streptozotocin inducerd diabetes mellitus and oxidative stress

Sıçanlarda L-karnitinin streptozotocinle diyabet oluşumu ve oksidan stres üzerine etkilerinin araştırılması

Giray Nazan YALAZ UYSAl
Osman AÇIKIGÖZ
Sevil GÖNENÇ
Muammer KAYATEKİN
Pages
1–8
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: No effect of L-carnitine was observed on streptozotocin induced diabetes.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The aim of this study was to investigate the role of L-carnitine on preventing diabetes nd its effects on pancreas lipid peroxidation.
📊
Key Findings & Data:Single dose 65 mg/kg IP. streptozotocin enjected to onset experimental diabetes mellitus.
💡
Conclusion & Impact:Conclusion: No effect of L-carnitine was observed on streptozotocin induced diabetes.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Karnitin · Diabetes mellitus · Lipid peroksidasyonu

Abstract

Objective: The aim of this study was to investigate the role of L-carnitine on preventing diabetes nd its effects on pancreas lipid peroxidation. Material and Methods: Adult Wistar Albino male rats were used in this study. Single dose 65 mg/kg IP. streptozotocin enjected to onset experimental diabetes mellitus. SOD, GPx and glucose measurements made by spectrophotometric methods. Protein levels were measured by Markwell's modified Lowry method and MDA levels were measured by the method of Rehnchona et al. Results: Giving L-carnitine prior to treptozotocin did not have any effects on the blood glucose levels in diabetes induced by treptozotocin. There was no significant change on the pancreas süperokside dismutase enzyme activity and TEARS levels, however glutathione peroksidase (GPx) activity was found to be increased in the diabetic group and compared the carnitin-taking group and the carnitin-taking diabetic group. Conclusion: No effect of L-carnitine was observed on streptozotocin induced diabetes.

Özet

Amaç: Bu çakşmanın amacı L-karnitinin diyabeti önlemedeki rolünün ve pankreas lipid peroksidasyonu üzerine etkilerinin incelenmesidir. Gereç ve Yöntem: Çalışmada erişkin Wister Albino cinsi erkek sıçanlar kullanıldı. Deneysel diyabet oluşturmak amacıyla 65 mg/kg İP streptozotocin uygulandı. SOD, GPx ve glukoz ölçümleri spektrofotometrik yöntemle yapıldı. Protein miktarları Markwell'in modifiye lowry MDA değerleri ise Rehnchona ve ark.yönternine göre ölçüldü. Bulgular: Streptozotocinden önce L-karnitin verilmesinin streptozotocinle oluşan diyabette kan şekeri üzerine bir etkisi olmamıştır. Pankreas süperoksit dismutaz enzim aktivitesinde anlamlı bir farklılık görülmemiştir ancak glutatyon peroksidaz (GPx) enzim aktivitesi diyabetik grupta 2 g/kg karnitin alan gruba ve 500 mg/kg karnitinalan diyabetik gruba göre yüksek olarak bulunmuştur. Sonuç: L-karnitinin streptozotocinle oluşan diyabet üzerine bir etkisi görülmemiştir.

🔖

Cite This Article

UYSAl, G. N. Y., AÇIKIGÖZ, O., GÖNENÇ, S., KAYATEKİN, M. (2002). The effects of L-carnitine on streptozotocin inducerd diabetes mellitus and oxidative stress. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi, Cilt: 16 - Sayı: 1, 1–8. https://ajindex.com/articles/212854

References (15)

  1. Wolff SP, Diabetes mellitus and free radicals. British Medical Bulltein 1993;49: 3;642-652
  2. Feingold KR, Funk JL. Disorders of the endocrine pancreas. McPhee SJ, Lingappa VR, Ganong WF, Lange JD, Pathophysiology of disease, Second edition, Appleton and Lange, USA, 1997;423-448
  3. Drash AL, Rudert WA, Borquaye S, et al. Effect of probucol on development of diabetes mellitus in BB rats. Am J cardiol 1988;62:27B- 30B
  4. Mitra SK, Gopumadhavan S, Muralidhar TS, et al. Effect of D-400, a herbomineral formulation on liver glycogen content and microscopic structure of pancreas and liver in streptozotocin induced diabetes in rats. Indian J Exp Biol 1996;34:964-967
  5. Yang J, Cherian MG. Protective effects of metallothionein on streptozotocin-iduced diabetes in rats. Life Science 1994;55:43-51. 6 Flechner I, Maruta K, Burkart V, et al. Effects of radical scavengers on the development of experimental diabetes. Diabetes Res 1990;13:67-73
  6. Papaccio G, Baccari GC, Frascatore S, et al. The vita- min-E derivative U-83836-E in the low-dose streptozocin-treated mouse: effects on diabetes development. Diabetes Res Clin Pract 1995;30:163-171
  7. Hu Y, Wang Y, Wang L, et al. Effects of nicotinamide on prevention and treatment of streptozotocin-induced diabetes mellitus in rats. Chin Med J (Engl) 1996;109:819-822
  8. Mandrup Poulsen T. Nicotinamide treatment in the prevention of IDDM, Diabetes Metab Reviews. 1993;9:295-309
  9. Reddi AS, Jyothirmayi GN, Leevy CB, et al. Effect of genetic diabetes and alcohol on tissue carnitine and inositol concentrations in mice. Alcohol Alcohol 1990;25:137-41
  10. Pitkanen MO, Martin JM, Hallman M, et al. Free radical activity during development of insulin dependent diabetes mellitus in rat. Life Science 1992;50:335-339
  11. Rabinowitch A, Suarez Pinzon WL, Strynadka K, et al. Pancreatic islet (3-cells by cytokines involves oxygen free radicals and aldehyde production. J Clin Endocrin Metab 1996;81:3197-3202
  12. Morabito E, Corsico N, Marzo A. Serum and urine levels of levocarnitine family components in genetically diabetic rats. Arzneimittelforschung 1994;44:965-968
  13. Pregant P, Schernthaner G, Legenstein E. Decreased plasma carnitine in Type I diabetes mellitus. Klin Wochenschr 16,1991;69511-516
  14. Soneru IL, Khan T, Orfalian Z, et al. Acetyl-L-carnitine effects on nerve conduction and glycemic regulation in experimental diabetes. Endocr Res 1997;23:27-36
  15. Kakkar R, Mantha SV, Kalra J, et al. Time course study of oxid