SavedAdd your journal

Journals / Düşünen Adam - Psikiyatri ve Nörolojik Bilimler Dergisi / 2013 / Cilt: 26 - Sayı: 3

Migren tipi ve gerilim tipi baş ağrıları bulunan hastalarda pirüvik ve laktik asit seviyeleri

Serum lactic acid and pyruvic acid levels in patients with migraine and tension type headache

Yavuz ALTUNKAYNAK
Musa ÖZTÜRK
Devrimsel Harika ERTEM
Betül GÜVELİ
Filiz OKAY UZUN
Zerrin YILDIRIM
Belgin MUTLUAY
Ayten DİRİCAN CEYHAN
Emine ALTUNKAYNAK
AYHAN KÖKSAL
Sevim BAYBAŞ
Pages
276–280
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Multi-disciplinary researches are needed to determine mitochondrial diseases in patients with migraine and tension like headache.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: MELAS (mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes) syndrome is frequently associated with migraine like headaches.
📊
Key Findings & Data:Methods: We evaluated 30 patients with migraine, 30 patients with tension like headache and 30 healthy control.
💡
Conclusion & Impact:Conclusion: Multi-disciplinary researches are needed to determine mitochondrial diseases in patients with migraine and tension like headache.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: MELAS (mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes) syndrome is frequently associated with migraine like headaches. The relationship between migraine and mitochondrial diseases is interesting. Also mitochondrial disorders in tension like headache still remain to be investigated. The aim of this report is to evaluate the serum lactic acid and pyruvic acid levels in patients with migraine and tension type headache and compare them with healthy control group. Methods: We evaluated 30 patients with migraine, 30 patients with tension like headache and 30 healthy control. Lactic and pyruvic acid levels in serum samples were measured by biochemical methods. Kruskal Wallis and Mann-Whitney tests were used for statistical analysis using SPSS 11.5 for Windows program. Results: Serum lactic and pyruvic acid levels in patients with migraine and tension type headache were significantly higher than control group. Conclusion: Multi-disciplinary researches are needed to determine mitochondrial diseases in patients with migraine and tension like headache.

Özet

Amaç: Bir mitokondriyal sitopati olan MELAS (Mitokondriyal miyopati, ensefalopati, laktik asidoz ve inme benzeri epizotlar) sendromuna migren tipi baş ağrıları sıklıkla eşlik eder. Bu nedenle, migren ile mitokondriyal bozukluklar arasındaki ilişki ilgi çekicidir. Ayrıca gerilim tipi baş ağrılarında da mitokondriyal anormallikler incelenmektedir. Biz de migrenli ve gerilim tipi baş ağrılarında mitokondriyal bozukluk varlığını araştırmak amacıyla serum laktik ve pirüvik asit düzeylerini ölçmeyi ve bu değerleri sağlıklı kontrol grubuyla karşılaştırmayı amaçladık. Yöntem: Çalışmaya, Uluslararası Baş Ağrısı Topluluğu’nun (IHS) 2004 sınıflama sistemine göre tanı almış 30 migrenli, 30 gerilim tipi baş ağrılı hasta ve 30 sağlıklı kontrol alındı. Çalışmaya katılanlardan alınan örneklerde serum laktik ve pirüvik asit düzeyleri biyokimyasal yöntemlerle çalışıldı. İstatistiksel analizler için SPSS programında Kruskal-Wallis Testi ve Mann-Whitney testleri kullanıldı. Bulgular: Migren ve gerilim tipi baş ağrısı olan hastaların serum laktik ve pirüvik asit düzeyleri, kontrol grubuyla karşılaştırıldığında anlamlı olarak yüksek bulundu. Sonuç: Migrenli ve gerilim tipi baş ağrılı hastalarda mitokondriyal bozuklukların araştırılması için geniş çaplı multidisipliner araştırmalar gereklidir.

🔖

Cite This Article

ALTUNKAYNAK, Y., ÖZTÜRK, M., ERTEM, D. H., GÜVELİ, B., UZUN, F. O., YILDIRIM, Z., MUTLUAY, B., CEYHAN, A. D., ALTUNKAYNAK, E., KÖKSAL, A., BAYBAŞ, S. (2013). Migren tipi ve gerilim tipi baş ağrıları bulunan hastalarda pirüvik ve laktik asit seviyeleri. Düşünen Adam - Psikiyatri ve Nörolojik Bilimler Dergisi, Cilt: 26 - Sayı: 3, 276–280. https://ajindex.com/articles/211686

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Wong LJ. Mitochondrial syndromes with leukoencephalopathies. Semin Neurol 2012; 32:55-61
  2. Pavlakis SG, Phillips PC, DiMauro S, De Vivo DC, Rowland LP. Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: a distinctive clinical syndrome. Ann Neurol 1984; 16:481-488
  3. Tsujikawa T, Yamamoto T, Ikawa M, Yoneda M, Kimura H. Crossed cerebellar hyperperfusion after MELAS attack followed up by whole brain continuous arterial spin labeling perfusion imaging. Acta Radiology 2012; 53:220-224
  4. Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders Second ed. Cephalalgia 2004; 24 (Suppl.1):9-160
  5. Buzzi MG, Moskowitz MA. The pathophysiology of migraine. J Headache Pain 2005; 6:105-111
  6. Hirano M, Pavlakis SG. Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke like episodes (MELAS): current concepts. J Child Neurol 1994; 9:4-13
  7. Desquiret-Dumas V, Gueguen N, Barth M, Chevrollier A, Hancock S, Wallace DC, Amati- Bonneau P, Henrion D, Bonneau D, Reynier P, Procaccio V. Metabolically induced heteroplasmy shifting and l-arginine treatment reduce the energetic defect in a neuronal-like model of MELAS. Biochim Biophysic Acta 2012; 24:12-15
  8. Emmanuele V, Silvers DS, Sotiriou E, Tanji K, DiMauro S, Hirano M. MELAS, MERRF and Kearns-Sayre overlap syndrome due to the mitochondrial DNA m.3291T>C mutation. Muscle Nerve 2011; 44:448-451
  9. Suzuki T, Nagao A, Suzuki T. Human mitochondrial diseases caused by lack of taurine modification in mitochondrial tRNAs. Wiley Interdiscip Rev RNA 2011; 2:376-386
  10. Wojewoda M, Zabłocki K, Szczepanowska J. Diseases caused by mutations in mitochondrial DNA. Postepy Biochem 2011; 57:222-229
  11. Mende S, Royer L, Herr A, Schmiedel J, Deschauer M, Klopstock T, Kostic VS, Schroeder M, Reichmann H, Storch A. Whole blood genome wide expression profiling and network analysis suggest MELAS master regulators. Neurol Res 2011; 33:638-655
  12. Glatz C, D’Aco K, Smith S, Sondheimer N. Mutation in the mitochondrial tRNA(Val) causes mitochondrial encephalopathy, lactic acidosis and stroke-like episodes. Mitochondrion 2011; 11:615-619
  13. Pilch J, Asman M, Jamroz E, Kajor M, Kotrys-Puchalska E, Goss M, Krzak M, Witecka J, Gmiński J, Sieroń AL. Surveyor nuclease detection of mutations and polymorphisms of mtDNA in children. Pediatr Neurol 2010; 43:325-330
  14. Skinhoz E. Hemodynamic changes in migraine aura. Arch Neur