AI Summary & Key Takeaways
AI InsightAll biochemical data were analyzed retrospectively.Results: Overall, 61.9% of patients were women; 38.1% of them were men.
📌 3 Key Takeaways
Abstract
Objective: This study aimed to find the relationship between intima-media thickness and proteinuria, which are early findings of atherosclerosis and renal failure in patients with metabolic syndrome.Methods: In our study, 63 patients with metabolic syndrome and 26 healthy subjects, as the control group, were involved. Both groups were over 40 years old in the study. In both groups, carotid intima-media thickness was measured with B-mode ultrasonography. All biochemical data were analyzed retrospectively.Results: Overall, 61.9% of patients were women; 38.1% of them were men. Also, 61.54% of the control group was female; 38.46% of them were men. Carotid intima-media thickness, level of glucose, urea, creatinine, high-density lipoprotein (HDL) cholesterol, uric acid, C-reactive protein (CRP), retinopathy (p<0.001), age (p=0.017), triglyceride (p=0.022), glomerular filtration rate (GFR) (p=0.029), proteinuria (p=0.035), abdominal circumference (p=0.006), body mass index (BMI) (p=0.047), and thyroid-stimulating hormone (TSH) (p=0.013) were significantly higher in patients with metabolic syndrome.Conclusion: In the patients with metabolic syndrome, carotid intima-media thickness and proteinuria are precursors of atherosclerosis. These findings are important predictions for the development of type II diabetes mellitus, coronary heart disease, and chronic kidney disease.
Özet
Amaç: Kliniğimize başvuran metabolik sendromlu hastalarda aterosklerozun ve böbrek yetmezliğinin erken bulgularından olan karotis intima-media kalınlığı ve proteinüri ilişkisi değerlendirildi.Yöntemler: Çalışmamızda kliniğimize başvuran metabolik sendromlu 40 yaş üstü toplam 63 hasta ve 26 kontrol grubu değerlendirmeye alındı. Her iki grupta karotis intima-media kalınlığı B mod doppler ultrasonografi ile değerlendirilirken, biyokimyasal veriler retrospektif olarak laboratuarlarımızda incelendi.Bulgular: Hastaların %61,9'u kadın, %38,1'i erkek toplam 63 kişiden oluşurken, kontrol grubu %61,54 kadın, %38,46 erkek toplam 26 kişiden oluşmaktaydı. Karotis intima- media kalınlığı, glukoz, üre, kreatinin, yüksek dansiteli (HDL) kolesterol, ürik asit, C-reaktif protein (CRP), retinopati (p<0,001), yaş (p=0,017), trigliserit (p=0,022), glomerüler fitrasyon hızı (GFR) (p=0,029), proteinüri (p=0,035), bel çevresi (p=0,006), vücut kitle indeksi (BMI) (p=0,047), tiroid stimulan hormon (TSH) (p=0,013) değerleri metabolik sendromlu hastalarımız lehine anlamlıydı.Sonuç: Metabolik sendromlularda karotis intima-media kalınlığı ve proteinüri aterosklerozun habercisi olup, Tip 2 DM, koroner kalp hastalığı ve kronik böbrek yetmezliğinin ön uyaranıdır.