Applications of sterile larvae of Lucilia sericata for the treatment of chronic wounds

Objective & Hypothesis:The objective of this study was to assess the efficacy of maggot therapy and to develop decontained maggot designs for the best use and effect.

📊

Key Findings & Data:We have enrolled 25 patients with non-healing chronic wounds (23 diabetic foot wounds, 2 ischemic foot wounds,) various wound size (mean 11,9±11,8 cm2 ).

💡

Conclusion & Impact:As a result, application of maggot therapy as a "package" in the treatment of patients with chronic wounds is practical and effective.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

The objective of this study was to assess the efficacy of maggot therapy and to develop decontained maggot designs for the best use and effect. In this study, we could maintenance of Lucilia sericata colony and sterile maggots in the insectariums. Contained maggot designs would be developed for the best use and effect for maggot therapy. We have enrolled 25 patients with non-healing chronic wounds (23 diabetic foot wounds, 2 ischemic foot wounds,) various wound size (mean 11,9±11,8 cm2 ). The clinical state of the wounds documented before and after maggot therapy. Gram-positive cocci and Gram-negative bacilli were the most frequently isolated from patients with chronic wounds in pretreatment. Along with packet that contains the sterile larvae of the second stage (average mean number of applications 3,6±1,6 packet; average mean 16,2±8,6 days) hyperbaric oxygen (HBO) was applied to patients. As a result of treatment of 19 patients (76%) provided a complete wound debridement, on the other hand, a partial debridement was occurred in six patients (24%). As a result, application of maggot therapy as a "package" in the treatment of patients with chronic wounds is practical and effective.

Özet

Bu çalışmada, maggot tedavisinin (MT) etkinliğini değerlendirmek ve en uygun ve etkin orijinal steril larva içeren paket dizaynlarının geliştirmek amaçlanmıştır. Maggot tedavisinin en iyi kullanım ve etkinliği için larva içeren paket sistemi geliştirilmiştir. Çalışmada çeşitli boyutlarda (ortalama 11,9±11,8 cm2) yaralar bulunan 23 diyabetik ayak ülseri (DAÜ), iki iskemik kronik yaralı olmak üzere toplam 25 kronik yaralı hasta alınmıştır. Yaranın klinik durumu tedavi öncesi ve sonrası ayrı ayrı değerlendirilmiştir. Tedavi öncesi, yaralarda Gram pozitif kok ve Gram negatif basil en sık olarak saptanmıştır. Hastalara MT (ortalama 16,2±8,6 gün) steril ikinci dönem larvaları içeren paket (ortalama 3,6±1,6 paket) ile birlikte hiperbarik oksijen (HBO) tedavisi uygulanmıştır. Tedavi sonucunda 19 hastanın (%76) yarasında tam bir debridman sağlanırken, altı hastada (%24) kısmi bir debridman oluşmuştur. Sonuç olarak; kronik yarası olan hastaların tedavilerinde steril maggot tedavisinin "paket" olarak uygulanmasının pratik olması yanında tedavide etkin olabildiği gözlenmiştir

🔖

Cite This Article

TANYÜKSEL, M., KORU, Ö., ARAZ, R. E., KILBAŞ, H. Z. G., YILDIZ, Ş., ALACA, R., Ay, H., ŞİMŞEK, K., YILDIZ, C., YURTTAŞ, Y., DEMİRALP, B., DEVECİ, M., BEŞİRBELLİOĞLU, B. A. (2014). Applications of sterile larvae of Lucilia sericata for the treatment of chronic wounds. Gülhane Tıp Dergisi, Cilt: 56 - Sayı: 4, 218–222. https://ajindex.com/articles/210903

📄 Full Text PDF Viewer

Open in New Tab ↗

↗New Tab

📄

PDF görüntüleyici hazırlanıyor...

References (18)

Graninger M, Grassberger M, Galehr E, et al. Biosurgical debridment facilitates healing of chronic skin ulcers. Arch Intern Med 2002; 162 (16): 1906-7
Tanyuksel M, Araz E, Dundar K, et al. Maggot debridement therapy in the treatment of chronic wounds in a military hospital setup in Turkey. Dermatology 2005; 210(2): 115-8
Wolff H, Hansson C. Larval therapy - an effective method of ulcer debridement. Clin Exp Dermatol 2003; 28(2): 134- 47
Wayman J, Nirojogi V, Walker A, et al. The cost effectiveness of larval therapy in venous ulcers. J Tissue Viability 2000; 10(3): 91-4
Wollina U., Liebold K, Schmidt WD, et al. Biosurgery supports granulation and debridement in chronic wounds- clinical data and remittance spectroscopy measurement. Int J Dermatol 2002; 41(10): 635-9
Dinçer Ş. İnsan ve Hayvanlarda Myiasis. In: Özcel MA, Daldal N T (eds). Parazitoloji’de Artropod Hastalıkları ve Vektörler. İzmir: Ege Üniversitesi Basımevi, 1997: 169- 234
Wollina U, Katre K, Herold C, et al. Biosurgery in wound healing–the renaissance of maggot therapy. JEADV 2000; 14: 285-9
Fleischmann W, Grassberger M, Sherman R. Maggot Therapy. A Handbook of Maggot–Assisted Wound Healing. Stuttgart: George Thieme Verlag, 2004: 1-93
Church JCT, Courtenay M. Maggot debridement therapy for chronic wounds. Lower Extremity Wounds 2002;1(2): 129-34
Thomas S, Jones M, Shutler S, et al. Using larvae in modern wound management. J Wound Care 1996; 5(2): 60- 9
Friedman E, Shaharabany M, Ravin S, et al. Partially purified antibacterial agent from maggots displays a wide range of antibacterial activity. Third International Conference on Biotherapy, 1998, Jerusalem, Israel
Church JCT. Larval intervention in the chronic wound. EWMA J 2001; 1(2): 10-13
Lerch K, Linde HJ, Lehn N, et al. Bacteria ingestion by blowfly larvae: an in vitro study. Dermatology 2003; 207(4): 362-6
Sherman RA, Pechter EA. Maggot therapy: a review of the therapeutic applications of fly larvae in human medicine, especially for treating osteomyelitis. Med Vet Entomol 1988; 2(3): 225-30
Sherman RA., Hall MJ, Thomas S. Medicinal maggots: An ancient remedy for some contemporary afflictions. Annu Rev Entomol 2000; 45: 55-81
Sherman RA. A new dressing design for use with maggot therapy. Plast Reconstr Surg 1997; 100(2): 451-6
Sherman RA, Tran JM, Sullivan R. Maggot therapy for venous stasis ulcers. Arch Dermatol 1996; 132(3): 254-6
Mumcuoglu KY, Ingber A, Gilead