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Journals / Glokom Katarakt / 2014 / Cilt: 9 - Sayı: 2

Ex-Press Mini Glaucoma Shunt Implantation with 5-Fluorouracil in Pseudophacic Open Angle Glaucoma Patients

Psödofak Açık Açılı Glokomu Olan Olgularda 5-Fluorourasil ile Ex-Press Mini Glokom Şant İmplantasyonu

Ahmet KARAKURT
M. Sinan SARICAOĞLU
Ayten KOCAMAN BULUT
Pages
117–121
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Few studies are present about Ex-press implantation in these pseudophacic patients and we think that firstly usage of 5-Fluorouracil will provide additional contribution to literature

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: To evaluate the outcomes of Ex-press mini glaucoma shunt implantation with 5-Fluorouracil (5-FU) in pseudophacic OAG ( open angle glaucoma) patients.Material and Methods: We assessed retrospectively 11 eyes of the 8 OAG patients whom had been operated with uncomplicated phacoemulsification surgery previously, and have high IOP despite maximal tolerable medication and then operated with ex-press shunt surgery with 5-Fluorouracil.Results: Cases are followed on average 15.3±7.5 months after the surgery.
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Key Findings & Data:Mean IOP (intraocular pressure) of 11 eyes was detected as 27.9+-3.2 mmHg pre-operatively and reduced to 13.6+/-2.2 mm Hg post-operatively at the last control.
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Conclusion & Impact:Few studies are present about Ex-press implantation in these pseudophacic patients and we think that firstly usage of 5-Fluorouracil will provide additional contribution to literature
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: To evaluate the outcomes of Ex-press mini glaucoma shunt implantation with 5-Fluorouracil (5-FU) in pseudophacic OAG ( open angle glaucoma) patients.Material and Methods: We assessed retrospectively 11 eyes of the 8 OAG patients whom had been operated with uncomplicated phacoemulsification surgery previously, and have high IOP despite maximal tolerable medication and then operated with ex-press shunt surgery with 5-Fluorouracil.Results: Cases are followed on average 15.3±7.5 months after the surgery. Mean IOP (intraocular pressure) of 11 eyes was detected as 27.9+-3.2 mmHg pre-operatively and reduced to 13.6+/-2.2 mm Hg post-operatively at the last control. Decrease in the IOP was statistically significant (p<0.05). Average number of pre-operative medications was 2.63±0.5 and none of the cases needed medical treatment post-operatively. We did not have any complication except cystic bleb occurrence in one patient. No significant change was recorded in visual acuity and c/d ratios.Conclusions: Although we have limited number of cases, Ex-press implantation with 5-Fluororuracil was found quite effective and safe in control of IOP in pseudophacic OAG patients. Few studies are present about Ex-press implantation in these pseudophacic patients and we think that firstly usage of 5-Fluorouracil will provide additional contribution to literature

Özet

Amaç: Psödofak açık açılı glokomu (AAG) olan olgularda 5-Fluorourasil (5-FU) ile Ex-press mini glokom şant implantasyonu ameliyatı sonuçlarının değerlendirilmesi amaçlandı.Gereç ve Yöntem: Fakoemülsifikasyon yöntemiyle komplikasyonsuz katarakt cerrahisi geçirmiş, tolere edilebilir maximum medikal tedaviye rağmen göz içi basıncı (GİB) kontrolü sağlanamaması nedeniyle 5-FU ile Ex-press mini glokom şant implantasyonu uygulanmış ileri evre 8 AAG'lu olgunun 11 gözüne ait kayıtlar geriye dönük olarak incelendi.Bulgular: Olgular ameliyat sonrası ortalama 15.3±7.5 (6-26 ay) süreyle takip edildiler. Ameliyat öncesi GİB ortalaması 27.9±3.2 mmHg olan olguların ameliyat sonrası son kontrol muayene GİB ortalaması 13.6±2.2 mmHg olarak tespit edildi. GİB'ndaki düşüş istatistiksel olarak anlamlıydı (p<0.05). Ameliyat öncesi ilaç sayısı ortalaması 2.63±0.5 iken ameliyat sonrası hiçbir gözde ilaç gereksinimi olmadı. Bir olguda görülen kistik blep dışında herhangi bir komplikasyonla karşılaşılmadı. Ameliyat sonrası olguların görme keskinlikleri ve c/d oranlarında anlamlı değişim gözlenmedi.Sonuç: Olgu sayımız sınırlı olmakla birlikte psödofakik AAG'lu olgularda 5-FU ile Ex-press şant implantasyonu GİB kontrolünde etkin ve güvenilir bulundu. Bu olgu grubunda Ex-press şant implantasyonu ile ilgili sınırlı sayıda rapor olup, çalışmamızın 5-FU ile birlikteliği açısından da literatüre ek katkı sağlayacağı düşüncesindeyiz

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Cite This Article

KARAKURT, A., SARICAOĞLU, M. S., BULUT, A. K. (2014). Ex-Press Mini Glaucoma Shunt Implantation with 5-Fluorouracil in Pseudophacic Open Angle Glaucoma Patients. Glokom Katarakt, Cilt: 9 - Sayı: 2, 117–121. https://ajindex.com/articles/210380

References (13)

  1. Yalvaç S I., Marangoz D. İmplant cerrahisi. Glo-Kat 2011;6:119-26.
  2. Iwao K, Inatani M, Seto T, et al. Long-term Outcomes and Prognostic Factors for Trabeculectomy With Mitomycin C in Eyes With Uveitic Glaucoma: A Retrospective Cohort Study. J Glaucoma 2012;14. Takihara Y, Inatani M, Seto T, et al. Trabeculectomy with mitomycin for open-angle glaucoma in phakic vs pseudo- phakic eyes after phacoemulsification. Arch Ophthalmol 2011;129:152-7.
  3. Awai-Kasaoka N, Inoue T, Takihara Y, et al. Impact of phaco- emulsification on failure of trabeculectomy with mitomycin-C. J Cataract Refract Surg 2012;38:419-24.
  4. Fontana H, Nouri-Mahdavi K, Caprioli J. Trabeculectomy with mitomycin C in pseudophakic patients with open-angle glaucoma: outcomes and risk factors for failure. Am J Oph- thalmol 2006;141:652-9. Mostafaei A. Augmenting trabeculectomy in glaucoma with sub- conjunctival mitomycin C versus subconjunctival 5-fluorouracil: a randomized clinical trial. Clin Ophthalmol 2011;5:491-4.
  5. Traverso CE, De Feo F, Messas-Kaplan A, et al. Long term effect on IOP of a stainless steel glaucoma drainage implant (Ex-PRESS) in combined surgery with phacoemulsification. Br J Ophthalmol 2005;89:425-9.
  6. Sarıcaoğlu M.S, Fidan B., Karakurt A.,ve ark. Afakik psödo- fakik olgularda mitomisin C ile trabekülektomi. T Oftalmol Gaz 2008,38:22-7.
  7. De Jong L, Lafuma A, Aguade AS, et al. Five-year extension of a clinical trial comparing the EX-PRESS glaucoma filtration device and trabeculectomy in primary open-angle glaucoma. Clin Ophthalmol 2011;5:527-33.
  8. Lankaranian D, Razeghinejad MR, Prasad A, et al. Inter- mediate-term results of the Ex-PRESS miniature glaucoma implant under a scleral flap in previously operated eyes. Clin Exp Ophthalmol 2011;39:421-8.
  9. Maris PJ, Jr Ishida K, Netland PA. Comparison of trabeculec- tomy with Ex-PRESS miniature glaucoma device implanted under scleral flap. J Glaucoma 2007;16:14-9.
  10. Saricaoglu MS, Karakurt A, Recep OF, et al. Retrieval of a mispositioned Ex-PRESS glaucoma device.Ophthalmic Surg Lasers 2008;39:404-6.
  11. Wamsley S, Moster MR, Rai S, et al. Results of the use of the Ex-PRESS miniature glaucoma implant in technically chal- lenging, advanced glaucoma cases: a clinical pilot study. Am Journal Ophthalmol 2004;138:1049-51.
  12. Salim S, Du H, Boonyaleephan S, et al. Surgical outcomes of the Ex-PRESS glaucoma filtration device in African American and white glaucoma patients. Clin. Ophthalmol 2012;6:955-62.
  13. Gallego-Pinazo R, Lopez-Sanchez E, Marin-Montiel J. Postop-