Journals / İzmir Tepecik Eğitim Hastanesi Dergisi / 2016 / Cilt: 26 - Sayı: 3

Kronik böbrek yetmezliğinde nazal mukosiliyer klirens: Diyaliz öncesi ve diyaliz dönemlerinin karşılaştırılması

Nasal mucociliary clearance in chronic renal failure: Comparision of pre-dialysis and dialysis stages

Pages
197–200
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Patients with CRF should be monitored closely for middle ear, sinonasal, and respiratory tract infections and informed about potential risks of infection.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Chronic renal failure (CRF) is an irreversible condition that has many otorhinolaryngological manifestations.
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Key Findings & Data:In this study we aimed to investigate the effects of CRF and haemodialysis treatment on nasal mucociliary clearance (MCC) and to explain the possible pathophysiological mechanisms.Methods: This study included 27 patients with end-stage CRF who were not undergoing haemodialysis (pre-dialysis group), 36 patients with CRF on haemodialysis (dialysis group), and 36 heathy individuals.
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Conclusion & Impact:Patients with CRF should be monitored closely for middle ear, sinonasal, and respiratory tract infections and informed about potential risks of infection.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Chronic renal failure (CRF) is an irreversible condition that has many otorhinolaryngological manifestations. In this study we aimed to investigate the effects of CRF and haemodialysis treatment on nasal mucociliary clearance (MCC) and to explain the possible pathophysiological mechanisms.Methods: This study included 27 patients with end-stage CRF who were not undergoing haemodialysis (pre-dialysis group), 36 patients with CRF on haemodialysis (dialysis group), and 36 heathy individuals. Nasalmucociliary clearance was measured using the saccharin clearance test (SCT) and the results were statistically compared among the three groups.Results: Mean SCT times in the control, pre-dialysis, and dialysis groups were 11.7±5.7, 30.16±11.66, and 27.33±9.4 min, respectively. The results for both the predialysis and dialysis groups were significantly higher when compared with the control group (both p<0.001). There was no significant difference between the pre-dialysis and dialysis groups (p=0.22).Conclusion: Both CRF and haemodialysis treatment cause severe prolongation of MCC time. Patients with CRF should be monitored closely for middle ear, sinonasal, and respiratory tract infections and informed about potential risks of infection.

Özet

Amaç: Kronik böbrek yetmezliği (KBY), kulak burun boğaz açısından birçok klinik bulgu oluşturan ve geri dönüşü olmayan bir durumdur. Bu çalışmada, KBY'nin ve hemodiyaliz tedavisinin nazal mukosiliyer klirens üzerine etkisinin araştırılması ve olası patofizyolojik mekanizmaların açıklaması amaçlanmıştır.Yöntemler: Bu çalışmaya, son dönem KBY olan ve diyaliz tedavisi almayan 27 hasta (pre-diyaliz grup), son dönem KBY olan ve diyaliz tedavisi almakta olan 36 hasta (diyaliz grubu) ve 36 sağlıklı birey (kontrol grubu) dahil edildi. Nazal mukosiliyer klirens ölçümü sakkarin klirens testi kullanılarak ölçüldü ve sonuçlar üç grup arasında istatistiksel olarak karşılaştırıldı.Bulgular: Ortalama sakkarin klirens testi zamanı kontrol, pre-diyaliz ve diyaliz gruplarında sırasıyla 11,7±5,7, 30,16±11,66 ve 27,33±9,4 dk. olarak bulundu. Prediyaliz ve diyaliz gruplarında, her iki grup için elde edilen sonuç kontrol grubuna göre anlamlı ölçüde yüksekti (her iki p<0,001), pre-diyaliz ve diyaliz grupları arasında anlamlı fark saptanmadı (p=0,22).Sonuç: Hem KBY hem de hemodiyaliz tedavisi nazal mukosiliyer klirens zamanında ciddi uzamaya neden olmaktadır. Bu nedenle KBY olan hastalar orta kulak, sinonazal veya solunum yolu enfeksiyonları açısından yakından takip edilmeli ve olası enfeksiyon risklerine karşın bilgilendirilmelidirler.

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Cite This Article

ULUYOL, S., ALP, A., KILIÇASLAN, S., GÜR, M. H. (2016). Kronik böbrek yetmezliğinde nazal mukosiliyer klirens: Diyaliz öncesi ve diyaliz dönemlerinin karşılaştırılması. İzmir Tepecik Eğitim Hastanesi Dergisi, Cilt: 26 - Sayı: 3, 197–200. https://ajindex.com/articles/209867

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