Effect of fluticasone propionate nasal drops on intraocular pressure

Key Findings & Data:Method: Ninety eight eyes of 49 adult patients who were prescribed fluticasone nasal drops for nasal poliposis or allergic rhinitis and did not have any systemic or ocular risk factors that may affect intraocular pressure were included in the study.

💡

Conclusion & Impact:However, larger groups of patients are required for further evaluation of the risk for increasing intraocular pressure.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Rinit · allerjik · sürekli

Abstract

Purpose: We aimed to investigate the effect of fluticasone propionate nasal drops on intraocular pressure. Method: Ninety eight eyes of 49 adult patients who were prescribed fluticasone nasal drops for nasal poliposis or allergic rhinitis and did not have any systemic or ocular risk factors that may affect intraocular pressure were included in the study. Intraocular pressure levels of all patients were measured before the treatment. Intraocular pressure measurements were repeated after an average treatment period of 9,53 ± 2,13 weeks. Pretreatment and posttreatment intraocular pressure values were compared statistically. Results: There was no statistically significant difference between pretreatment and posttreatment intraocular pressure levels (p=0.516 and p=0.940 for the right and left eyes, respectively). Conclusion: Our study demonstrates that treatment with fluticasone propionate nasal drops does not cause a significant change in the intraocular pressure. However, larger groups of patients are required for further evaluation of the risk for increasing intraocular pressure.

Özet

Amaç: Flutikazon propiyonat nazal damla tedavisinin göz içi basıncına(GİB) etkisini araştırmayı amaçladık. Yöntem: Nazal polipozis veya allerjik rinit tanısı konularak flutikazon propiyonat nazal damla tedavisi başlanan ve GİB’ nı etkileyebilecek sistemik veya oküler hastalığı bulunmayan 49 erişkin hastanın 98 gözü çalışmaya alındı. Tedaviden önce hastaların GİB’ları ölçüldü. Ortalama 9,53 ± 2,13 haftalık tedavi sonrasında GİB ölçümleri tekrarlanarak tedavi öncesi ve sonrası değerler istatistiksel olarak karşılaştırıldı. Bulgular: Tedavi öncesi ve sonrasında GİB değerlerinde istatistiksel açıdan anlamlı bir fark saptanmadı (sağ ve sol gözler için sırasıyla p=0,516 ve p=0,940). Sonuçlar: Çalışmamız flutikazon propiyonat nazal damlanın glokomla ilgili diğer risk faktörleri olmayan hastalarda GİB’ nda anlamlı bir değişikliğe yol açmadığını göstermiştir. Güvenilirliğin daha iyi değerlendirilebilmesi için daha büyük hasta gruplarına ihtiyaç vardır.

Keywords

Rinit allerjik sürekli Göz içi basınç Nazal polipler Rhinitis Allergic Perennial Intraocular Pressure Nasal Polyps

🔖

Cite This Article

SERİN, D., KÖYBAŞI, S., ALAGÖZ, G., YILMAZ, F., KÜKNER, Ş. (2005). Effect of fluticasone propionate nasal drops on intraocular pressure. KBB-Forum, Cilt: 4 - Sayı: 3, 119–122. https://ajindex.com/articles/209364

📄 Full Text PDF Viewer

Open in New Tab ↗

↗New Tab

📄

PDF görüntüleyici hazırlanıyor...

References (5)

McDonald J. Manifestations of systemic disease of the nose. In: Cummings CW, Frederickson JM, Harker LA, eds. Otolaryngology Head and Neck Surgery, 3rd ed. St Louis: Mosby, 1998
Michels MI, Smith RE, Hemlich EM. Adrenal suppression and intranasally applied steroids. Ann Allergy 1967;25:569-574. [ Özet ] 3) Opatowsky I, Feldman RM, Gross R, Feldman ST. Intraocular pressure elevation associated with inhalation and nasal corticosteroids. Ophthalmology 1995;102:177-179. [ Özet ] 4) Desnoeck M, Casteels I, Casteels K. Intraocular pressure elevation in a child due to the use of inhalation steroids-a case report. Bull Soc Belge Ophthalmol 2001;280:97-100. [ Özet ] 5) Mitchell P, Cumming RG, Mackey DA. Inhaled corticosteroids, family history, and risk of glaucoma. Ophthalmology 1999;106:2301-2306. [ Özet ] 6) Yıldırım N. Kortikosteroid glokomu. In: Turaçlı ME, Önol M, Yalvaç IS, eds. Glokom, 1. baskı. Ankara: SFN, 2003: 106
Tasman W, Jaeger E, Duane S. Foundations of Clinical Ophthalmology, 2nd ed. Philadelphia: JB Lippincott, 1996
Dibildox J. Safety and efficacy of mometasone furoate aqueous nasal spray in children with allergic rhinitis: results of recent clinical trials. J Allergy Clin Immunol 2001;108:S54-58. [ Özet ] 9) Öztürk F, Yücetürk AV, Kurt E, Ünlü HH, İlker SS. Evaluation of intraocular pressure and cataract formation following the long-term use of nasal corticosteroids. Ear Nose Throat 1998;77:846-851. [ Özet ] 10) Samiy N, Walton DS, Dreyer EB. Inhaled steroids: effect on intraocular pressure in patients without glaucoma. Can J Ophthalmol 1996;31:120-123. [ Özet ] 11) Duh MS, Walker AM, Lindmark B, Laties AM. Association between intraocular pressure and budesonide inhalation therapy in asthmatic patients. Ann Allergy Asthma Immunol 2000;85:356-361. [ Özet ] 12) Sihota R, Dada T, Rai HK. Fluticasone propionate raises intraocular pressure in susceptible individuals. Indian J Ophthalmol 2004;52:170-171. [ Özet ] 13
Bross-Soriano DB, Milver CH, Idı JS, Gomez JRA, Del Toro RA, Escobar GB. Effects of three nasal topical steroids in the intraocular pressure compartment. Otolaryngol Head Neck Surg 2004;130:187-191. [ Özet ]