Our purpose of this study is to review current knowledge on genes associated with intervertebral disc degeneration
📌 3 Key Takeaways
🎯
Objective & Hypothesis:Although development of the intervertebral disc disease is a multifactorial condition, recent studies associated with genes playing a role in disc dejeneration revealed that the importance of the genetic factors in the development of disc disease.
📊
Key Findings & Data:Although development of the intervertebral disc disease is a multifactorial condition, recent studies associated with genes playing a role in disc dejeneration revealed that the importance of the genetic factors in the development of disc disease.
💡
Conclusion & Impact:Our purpose of this study is to review current knowledge on genes associated with intervertebral disc degeneration
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Although development of the intervertebral disc disease is a multifactorial condition, recent studies associated with genes playing a role in disc dejeneration revealed that the importance of the genetic factors in the development of disc disease. Our purpose of this study is to review current knowledge on genes associated with intervertebral disc degeneration
Özet
İntervertebral disk hastalığının gelişimi her ne kadar multifaktöriyel bir durum olsa da, disk dejenerasyonunda rol oynayan genlerle ilişkili son zamanda yapılan çalışmalar, genetik faktörlerin disk hastalığı gelişimindeki rollerinin önemini ortaya koymuştur. Bu çalışmadaki amacımız intervertebral disk dejenerasyonunda rol oynayan genlerle ilgili mevcut bilgilerin gözden geçirilmesidir
🔖
Cite This Article
KAHVECİ, R., ÖZEVREN, H., KARAVELİOĞLU, E. (2015). DEJENERATİF DİSK HASTALIĞI VE GENETİK. Journal of Turkish Spinal Surgery, Cilt: 26 - Sayı: 1, 71–82. https://ajindex.com/articles/208766
Anderson DG, Izzo MW, Hall DJ, Vaccaro AR, Hilibrand A, Arnold W, Tuan RS, Albert TJ. Comparative gene expression profiling of normal and degenerative discs: analysis of a rabbit annular laceration model. Spine 2002; 27: 1291-1296
Annunen S, Paassilta P, Lohiniva J, Perala M, Pihlajamaa T, Karppinen J, Tervonen O, Kroger H, Lahde S, Vanharanta H, Ryhanen L, Goring HH, Ott J, Prockop DJ, Ala-Kokko L. An allele of COL9A2 associated with intervertebral disc disease. Science 1999; 285: 409–412
Bachmeier BE, Nerlich A, Mittermaier N, Weiler C, Lumenta C, Wuertz K, Boos N. Matrix metalloproteinase expression levels suggest distinct enzyme roles during lumbar disc herniation and degeneration. Eur Spine J 2009; 18: 1573-1586
Battie MC, Videman T, Gibbons LE, Fisher LD, Manninen H, Gill K. 1995 Volvo Award in clinical sciences. Determinants of lumbar disc degeneration. A study relating lifetime exposures and magnetic resonance imaging findings in identical twins. Spine 1995;20: 2601-2612
Bergknut N, Rutges JP, Kranenburg HJ, Smolders LA, Hagman R, Smidt HJ, Lagerstedt AS, Penning LC, Voorhout G, Hazewinkel HA, Grinwis GC, Creemers LB, Meij BP, Dhert WJ. The dog as an animal model for intervertebral disc degeneration? Spine 2012; 37: 351-358
Bolt MJ, Liu W, Qiao G, Kong J, Zheng W, Krausz T, Cs-Szabo G, Sitrin MD, Li YC. Critical role of vitamin D in sulfate homeostasis: regulation of the sodium sulfate cotransporter by 1,25-dihydroxyvitamin D3. Am J Physiol Endocrinol Metab 2004; 287: 744-749
Boyd LM, Richardson WJ, Allen KD, Flahiff C, Jing L, Li Y, Chen J, Setton LA. Early-onset degeneration of the intervertebral disc and vertebral end plate in mice deficient in type IX collagen. Arthritis Rheum 2008; 58: 164-171
Canbay S, Turhan N, Bozkurt M, Arda K, Caglar S. Correlation of matrix metalloproteinase-3 expression with patient age, magnetic resonance imaging and histopathological grade in lumbar disc degeneration. Turk Neurosurg 2013; 23: 427-433
Chen S, Huang Y, Zhou ZJ, Hu ZJ, Wang JY, Xu WB, Fang XQ, Fan SW. Upregulation of tumor necrosis factor α and ADAMTS-5, but not ADAMTS-4, in human intervertebral cartilage endplate with modic changes. Spine 2014; 39: 817-825. 10-Cheung KM, Chan D, Karppinen J, Chen Y, Jim JJ, Yip 337 SP, Ott J, Wong KK, Sham P, Luk KD, Cheah KS, Leong JC, Song YQ. Association of the Taq I allele in vitamin D receptor with degenerative disc disease and disc bulge in a Chinese population. Spine 2006; 31: