AI Summary & Key Takeaways
AI InsightRelapse was more frequently seen in patients with neurological deficits, symptomatic etiology of epilepsy, cases whose treatment period was less than two years, and those whose drugs were tapered within less than 3 months, patients with electroencephalographic findings were abnormal before remission, and those receiving politherapy.Conclusion: While tapering the antiepileptic drugs, history of neurological deficits, alındığı tarih: 06.01.2015 treatment period, drug tapering rate, electroencephalographic findings before remission, seizure type and number of drugs used are important guiding tools for us.
📌 3 Key Takeaways
Abstract
Objective: To evaluate retrospectively the relapse rates of epilepsy associated with antiepileptic drug withdrawal in epileptic children and to determine the risk factors effecting on seizure recurrence.Methods: Eigty-eight children with epilepsy who were seizure-free for at least 2 years were evaluated. Patients with recurrent seizure after drug withdrawal evaluated as a relapse group and seizure free patients evaluted as a remission group. Patients were followed for 2 years after antiepileptic drug withdrawal. Factors that may cause relapse were analyzed.Results: The study group consisted of 57% of the patients with relapse, and 43% patients with remission. Relapse was more frequently seen in patients with neurological deficits, symptomatic etiology of epilepsy, cases whose treatment period was less than two years, and those whose drugs were tapered within less than 3 months, patients with electroencephalographic findings were abnormal before remission, and those receiving politherapy.Conclusion: While tapering the antiepileptic drugs, history of neurological deficits, alındığı tarih: 06.01.2015 treatment period, drug tapering rate, electroencephalographic findings before remission, seizure type and number of drugs used are important guiding tools for us.
Özet
Amaç: Epilepsi tanılı çocuklarda antiepileptik ilaç kesimi sonrası relaps oranlarının ve relapsa etki eden risk faktörlerinin retrospektif olarak değerlendirilmesi. Yöntemler: İki yıllık nöbetsiz izlemi sonrası antiepileptik ilaç tedavisi kesilen 88 hasta değerlendirilmeye alınmıştır. Tedavi kesimi sonrası nöbeti yineleyen hastalar relaps grubu olarak, nöbeti yinelemeyenler ise remisyon grubu olarak incelenmiştir. Antiepileptik ilaç kesiminden sonra hastalar 2 yıl izlenmiş ve relapse neden olabilecek faktörler incelenmiştir.Bulgular: Çalışma grubuna alınan hastaların %57'si relaps, %43'ü remisyon olan hastalardan oluşuyordu. Nörolojik defisiti olan, epilepsi etyolojisi semptomatik olan, tedavi süresi iki yılın altında olan, ilaç kesim hızı üç ayın altında olan, remisyon öncesi elektroensefalogram bulgusu anormal olan ve politerapi kullanan hastalarda relaps sık görülmüştür.Sonuç: Antiepileptik ilaçları azaltırken nörolojik defisiti varlığı, tedavi süresi, ilaç kesim hızı, remisyon öncesi elektroensefalogram bulguları, nöbet tipi ve kullandığı ilaç sayısı relaps açısından bizim için önemli yol gösterici araçlardır.