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Journals / Genel Tıp Dergisi / 2012 / Cilt: 22 - Sayı: 2

Effects of curcumin supplementation on oxidant/antioxidant status of heart tissue in aged rats

Yaşlı sıçanlarda kurkumin takviyesinin kalp dokusunun oksidan/antioksidan durumu üzerine etkileri

MUAZ BELVİRANLI
NİLSEL OKUDAN
KISMET ESRA NURULLAHOĞLU ATALIK
Pages
61–66
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Curcumin supplementation protects the heart against oxidative damage and it improves antioxidant defense system in aged female rats.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of the study was to investigate the effects of curcumin supplementation on oxidative stress and antioxidant defense in heart tissue of aged female rats.
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Key Findings & Data:In curcumin supplemented group curcumin was given at 300 mg/kg dosage for 12 days via oral gavage dissolved in corn oil.
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Conclusion & Impact:Conclusion: Curcumin supplementation protects the heart against oxidative damage and it improves antioxidant defense system in aged female rats.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of the study was to investigate the effects of curcumin supplementation on oxidative stress and antioxidant defense in heart tissue of aged female rats. Methods: Twenty aged female rats (aged twenty months) were randomly divided into two grops: control and curcumin. In curcumin supplemented group curcumin was given at 300 mg/kg dosage for 12 days via oral gavage dissolved in corn oil. Twenty-four hour after the last supplementation heart tissues were taken under anesthesia and malondialdehyde (MDA), protein carbonyl (PC) and glutathione (GSH) levels were analyzed in these samples. Results: Curcumin supplementation significantly elevated GSH levels (P<0.05). However, although it was not statistically significant, curcumin supplementation decreased MDA and PC levels (P>0.05). Conclusion: Curcumin supplementation protects the heart against oxidative damage and it improves antioxidant defense system in aged female rats.

Özet

Amaç: Çalışmanın amacı kurkumin takviyesinin yaşlı dişi sıçanların kalp dokusunda oksidatif stres ve antioksidan savunma üzerine etkilerini araştırmaktı. Yöntem: Çalışmada 20 aylık 20 dişi Wistar sıçan kontrol ve kurkumin grupları olmak üzere rastgele 2 gruba ayrıldı. Kurkumin grubuna 12 gün boyunca günde 300 mg/kg dozunda kurkumin mısır yağı içerisinde çözülerek oral gavaj yoluyla verildi. Son takviyeden 24 saat sonra anestezi altında kalp dokuları alındı ve alınan örneklerde malondialdehit (MDA), protein karbonil (PC) ve glutatyon (GSH) seviyeleri analiz edildi. Bulgular: Kurkumin takviyesi GSH seviyelerini önemli ölçüde artırmıştır (P 0,05). Sonuç: Kurkumin takviyesi yaşlı dişi sıçanlarda kalp dokusunu oksidatif hasara karşı korur ve antioksidan savunma sistemini güçlendirir.

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Cite This Article

BELVİRANLI, M., OKUDAN, N., ATALIK, K. E. N. (2012). Effects of curcumin supplementation on oxidant/antioxidant status of heart tissue in aged rats. Genel Tıp Dergisi, Cilt: 22 - Sayı: 2, 61–66. https://ajindex.com/articles/208452

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References (16)

  1. Johnson FB, Sinclair DA, Guarente L. Molecular biology of aging. Cell. 1999;96:291-302
  2. Dkhar P, Sharma R. Effect of dimethylsulphoxide and curcumin on protein carbonyls and reactive oxygen species of cerebral hemispheres of mice as a function of age. Int J Dev Neurosci. 2010;28:351-7
  3. Harman D. Aging: A theory based on free radical and radiation chemistry. J Gerontol. 1956;11:298-300
  4. Çakatay U, Telci A, Yılmaz İA, Akçay T, Sivas A. Yaşlanmanın plazma oksidatif protein hasarına etkisi. Cerrahpaşa Tıp Derg. 2000;31:220-3
  5. Sastre J, Pallardó FV, Viña J. Mitochondrial oxidative stress plays a key role in aging and apoptosis. IUBMB Life. 2000;49:427-35
  6. Boveris A, Chance B. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J. 1973;134:707-16
  7. Lee HC, Wei YH. Mitochondria and aging. Adv Exp Med Biol. 2012;942:311-27
  8. Ago T, Matsushima S, Kuroda J, Zablocki D, Kitazono T, Sadoshima J. The NADPH oxidase Nox4 and aging in the heart. Aging (Albany NY). 2010;2:1012-6
  9. Doria E, Buonocore D, Focarelli A, Marzatico F. Relationship between human aging muscle and oxidative system pathway. Oxid Med Cell Longev. 2012;830257:1-12 10. Garcia-Fernandez M, Sierra I, Puche JE, Guerra L, CastillaCortazar I. Liver mitochondrial dysfunction is reverted by insulin-like growth factor II (IGF-II) in aging rats. J Transl Med. 2011;9:123
  10. Matthews RT, Yang L, Browne S, Baik M, Beal F. Coenzyme Q10 adminstration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci. 1998;95:8892-7
  11. Suh JH, Shigeno ET, Morrow JD, Cox B, Rocha AE, Frei B, et al. Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-a-lipoic acid. Faseb J. 2001;15:700-6
  12. Binienda ZK. Neuroprotective effects of L-carnitine in induced mitochondrial dysfunction. Ann NY Acad Sci. 2003;993:289-95
  13. Cherniack EP. T he potential influence of plant polyphenols on the aging process. Forsch Komplement med. 2010;17:181-7
  14. Ferrari CK. Functional foods and physical activities in health promotion of aging people. Maturitas. 2007;58:327-39
  15. Naik SR, Thakare VN, Patil SR. Protective effect of curcumin on experimentally induced inflammation, hepatotoxicity and cardiotoxicity in rats: evidence of its antioxidant property. Exp Toxicol Pathol. 2011;63:419-31
  16. Reddy AC, Lokesh BR. Studies on the inhibitory effects of curcumin and eugenol on the format