SavedAdd your journal

Journals / KONURALP TIP DERGİSİ / 2015 / Cilt: 7 - Sayı: 2

-

Nötrofil/lenfosit Oranının Pemfigus Vulgaris ile İlişkisi

Derya UÇMAK
Meltem AKKURT
Haydar UÇAK
Mustafa ARICA
Pages
88–92
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: Neutrophil count, NLR, ESR and CRP levels of the patients with PV were higher than the controls (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Pemphigus vulgaris (PV) is an autoimmune blistering skin disease.
📊
Key Findings & Data:Methods: A total of 49 newly diagnosed patients with PV and 48 healthy controls were included in the study.
💡
Conclusion & Impact:Results: Neutrophil count, NLR, ESR and CRP levels of the patients with PV were higher than the controls (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Nötrofil-Lenfosit Oranı · Pemfigus Vulgaris · İnflamasyon

Abstract

Aim: Pemphigus vulgaris (PV) is an autoimmune blistering skin disease. The aim of this study is to determine the relationship between the neutrophil-to-lymphocyte ratio (NLR) and PV. Methods: A total of 49 newly diagnosed patients with PV and 48 healthy controls were included in the study. The patients were grouped into mild, moderate and severe types according to the dose of administered corticosteroids. All data was obtained using inpatient records. Disease severity, findings on physical examination, complete blood count (CBC), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) parameters were noted. Lymphocyte and neutrophil numbers were noted from CBC findings. The NLR was compared between the patients and controls and among the patient groups. Analysis of data was done using SPSS 15.0. Results: Neutrophil count, NLR, ESR and CRP levels of the patients with PV were higher than the controls (p

Özet

Amaç: Pemfigus vulgaris (PV), otoimmün kökenli, bül oluşumuyla seyreden bir deri hastalığıdır. Bu çalışmanın amacı, PV hastalarındaki inflamasyon ile nötrofil-lenfosit oranı (NLO) arasındaki ilişkiyi belirlemektir. Yöntem: Çalışmaya 49 yeni tanı konan pemfigus vulgaris hastası ile 48 sağlıklı birey dahil edildi. Hastalar, hastalığın şiddetine bağlı olarak başlanan steroid dozuna göre; hafif, orta ve şiddetli hastalık olarak üç alt grupta sınıflandırıldı. Tüm veriler yatan hasta kayıtlarının incelenmesiyle elde edildi. Tüm hastalarda hastalık şiddet indeksi, muayene bulguları, tam kan sayımı (TKS), C reaktif protein (CRP) ve eritrosit sedimentasyon hızı (ESH) incelendi. Lenfosit ve nötrofil sayısı TKS verilerinden not edildi. Nötrofil-lenfosit oranı (NLO), hastalık alt grupları arasında ve kontroller ile SPSS 15,0 programı kullanılarak karşılaştırıldı. Bulgular: Çalışmamızda nötrofil sayısı, NLO, ESH ve CRP düzeyleri pemfiguslu hastalarda kontrollerden yüksekti (sırasıyla, p

🔖

Cite This Article

UÇMAK, D., AKKURT, M., UÇAK, H., ARICA, M. (2015). -. KONURALP TIP DERGİSİ, Cilt: 7 - Sayı: 2, 88–92. https://ajindex.com/articles/205264

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (11)

  1. Eming R, Nagel A, Wolff-Franke S, et al. Rituximab exerts a dual effect in pemphigus vulgaris. J Invest Dermatol 2008; 128(12): 2850-8.
  2. Kim EY, Moudgil KD. Regulation of autoimmune inflammation by pro-inflammatory cytokines. Immunol Lett 2008; 120(1-2): 1–5. D’Auria L, Bonifati C, Mussi A, et al. Cytokines in the sera of patients with pemphigus vulgaris: interleukin-6 and tumour necrosis factor-alpha levels are significantly increased as compared to healthy subjects and correlate with disease activity. Eur Cytokine Netw 1997; 8(4): 383–7.
  3. Mortazavi H, Babaeijandaghi F, Akbarzadeh M, et al. The influence of systemic therapy on the serum levels of IL-6 and IL-8 in pemphigus vulgaris. J Eur Acad Dermatol Venereol 2013; 27(3): 387-90.
  4. Keskin D, Stern J, Fridkis-Hareli M, Razzaque Ahmed A. Cytokine profiles in pemphigus vulgaris patients treated with intravenous immunoglobulins as compared to conventional immunosuppressive therapy. Cytokine 2008; 41(3): 315–21. Tirado-Sánchez A, Vázquez-González D, Ponce-Olivera RM, Montes de Oca-Sánchez G. Serum lactate is a useful predictor of death in severe sepsis in patients with pemphigus vulgaris. Acta Dermatovenerol Alp Panonica Adriat. 2012; 21(1): 7-9.
  5. Yazdanpanah MJ, Ghayour-Mobarhan M, Taji A, et al. Serum zinc and copper status in Iranian patients with pemphigus vulgaris. Int J Dermatol. 2011; 50(11): 1343-6.
  6. Yesilova Y, Ucmak D, Selek S, et al. Oxidative stress index may play a key role in patients with pemphigus vulgaris. J Eur Acad Dermatol Venereol. 2013; 27(4): 465-7.
  7. Yousefi M, Rahimi H, Barikbin B, et al. Uric Acid: a new antioxidant in patients with pemphigus vulgaris. Indian J Dermatol. 2011; 56(3): 278-81.
  8. Franquini Junior J, Adad SJ, Murta AH, de Morais Ca, Teixeira Vde P, Rodrgues Junior V. Tests of inflammatory activity in endemic pemphigus foliaceus. Rev Soc Bras Med Trop. 1994; 27(1): 25-9.
  9. Lee GK, Lee LC, Chong E, et al. The long-term predictive value of the neutrophil-to-lymphocyte ratio in Type 2 diabetic patients presenting with acute myocardial infarction. QJM 2012; 105(11): 1075–82.
  10. Nunez J, Nunez E, Bodi V, et al. Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in ST segment elevation myocardial infarction. Am J Cardiol 2008; 101(6): 747–52.
  11. Sen N, Afsar B, Ozcan F, et al. The neutrophil to lymphocyte ratio was associated with impaired myocardial perfusion and long term adverse outcome in patients with ST-elevated myocardial infarction undergoing primary coro