Journals / Glokom Katarakt / 2015 / Cilt: 10 - Sayı: 2

The Characteristics of Patients with Normal-Tension Glaucoma and the Effect of the Cardiovascular Findings on the Progression of the Glaucoma

Normal Basınçlı Glokom Hastalarında Klinik Özellikler ve Kardiovasküler Bulguların Glokomun Progresyonu Üzerine Olan Etkisi

Pages
84–90
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Despite relatively similar intraocular pressure and visual field examination findings between progressed and stable patients, cardiovascular systemic examination should be kept in mind in the cases with normal-tension glaucoma when especially progression of the disease occur in their follow ups.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: To investigate the clinical characteristics of patients with normal-tension glaucoma and the effect of the cardiovascular findings on the progression of the glaucoma.
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Key Findings & Data:Materials and Methods: The medical records of 80 eyes of 40 normal-tension glaucoma patients (25 women, 15 men) with typical glaucomatous optic disc and/or visual field changes and no recorded intraocular pressure >21 mmHg, who were treated with topical medications, were reviewed.
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Conclusion & Impact:Conclusion: Despite relatively similar intraocular pressure and visual field examination findings between progressed and stable patients, cardiovascular systemic examination should be kept in mind in the cases with normal-tension glaucoma when especially progression of the disease occur in their follow ups.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: To investigate the clinical characteristics of patients with normal-tension glaucoma and the effect of the cardiovascular findings on the progression of the glaucoma. Materials and Methods: The medical records of 80 eyes of 40 normal-tension glaucoma patients (25 women, 15 men) with typical glaucomatous optic disc and/or visual field changes and no recorded intraocular pressure >21 mmHg, who were treated with topical medications, were reviewed. Normal-tension glaucoma progression was defined by either structural (optic disc or retinal nerve fibre layer) or functional (visual field) deterioration. Results: The average follow-up period was 5.1±4.06 years, and 15 of 40 patients (37.5%) showed the normal-tension glaucoma progression. There were 25 stable patients (62.5%). Mean intraocular pressure measured higher in the progressed patients (14.53±3.27 mmHg) than stable patients (14.18±2.94 mmHg), but it was not statistically different between the groups (p=0.638). The disc size was bigger in progressed patients (2.16±0.25 µm) than stable patients (1.99±0.39 µm), (p=0.05). The age, central corneal thickness, visual field examination findings and the mean retinal nerve fiber layer at the initial examination were similar between progressed and stable patients (p>0.05). The diastolic fluctuations in progressed patients was higher than stable group (p=0.041) and progressed patients’ diastolic blood pressure measures at night were lower than stable patients (p=0.032). Conclusion: Despite relatively similar intraocular pressure and visual field examination findings between progressed and stable patients, cardiovascular systemic examination should be kept in mind in the cases with normal-tension glaucoma when especially progression of the disease occur in their follow ups.

Özet

Amaç: Normal basınçlı glokom tanısı ile takip edilen olguların klinik özelliklerini ve kardiovasküler bulguların glokomun progresyonu üzerine olan etkisini araştırmak. Gereç ve Yöntem: Tipik glokomatöz optik disk ve/veya görme alanı değişikliği olan ve göz içi basıncı >21 mmHg olarak saptanmamış, topikal medikasyon ile tedavi edilmiş normal basınçlı glokomu bulunan 40 hastanın (25 kadın, 15 erkek) 80 gözüne ait medikal bilgiler incelendi. Normal basınçlı glokomdaki progresyon yapısal (optik disk ve retina sinir lifi tabakası) ve fonksiyonel (görme alanı) olarak tanımlandı. Bulgular: Ortalama takip süresi 5.1±4.06 yıldı ve 40 hastanın 15’inde (%37.5) normal basınçlı glokomda progresyon saptandı. Yirmi beş stabil hasta (%62.5) mevcuttu. Ortalama göz içi basıncının progresyon gösteren grupta (14.53±3.27 mmHg) stabil gruba (14.18±2.94 mmHg) göre daha yüksek olduğu; ancak bunun istatistiksel olarak anlamlı olmadığı belirlendi (p=0.638). Optik disk, progresyon gösteren grupta (2.16±0.25µm) stabil gruba (1.99±0.39 µm) göre daha büyüktü (p=0.05). Yaş, santral kornea kalınlığı, görme alanı bulguları ve retina sinir lifi tabakası kalınlığı açısından progresyon gösteren olgular ile stabil olgular benzerdi (p>0.05). Progresyon gösteren grupta diyastolik kan basıncındaki dalgalanmanın stabil gruba göre anlamlı derecede fazla olduğu (p=0.041); ayrıca gece diyastolik kan basıncı değerlerinin stabil gruptan anlamlı derecede daha düşük olduğu saptandı (p=0.032). Sonuç: Progresyon gösteren ve stabil hastalar arasında göz içi basıncı düzeyi ve görme alanı sonuçları benzer olmasına rağmen, özellikle takiplerinde progresyon saptanan normal basınçlı glokom hastalarında kardiovasküler sistemik inceleme akılda tutulmalıdır.

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Cite This Article

ÇORAK, F. E., GÜNGÖR, S. G., GÜNEŞ, Y., AKMAN, A. (2015). The Characteristics of Patients with Normal-Tension Glaucoma and the Effect of the Cardiovascular Findings on the Progression of the Glaucoma. Glokom Katarakt, Cilt: 10 - Sayı: 2, 84–90. https://ajindex.com/articles/201617

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