The rats were anesthetized to study the otoacoustic emissions before and after the experiment.Results: The OAEs were attenuated in the cisplatin group: (-1.31/-4.90), (6.28/4.58), (4.00/0.93), (2.73/-3.74), (2.66/-4.53).The group that received NAC in addition to cisplatin had better OAEs.Conclusion: Cisplatin ototoxicity can be detected by OAE testing in rats, and NAC may reduce the ototoxic effect.
📌 3 Key Takeaways
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Objective & Hypothesis:Objective: To investigate the changes in otoacoustic emissions (OAEs) for detecting the ototoxicity of cisplatin and to study the possible preventive effect of N-acetylcysteine (NAC) in cisplatin ototoxicity.Materials and Methods: This study was conducted on 21 Wistar albino rats in four groups.
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Key Findings & Data:Cisplatin, cisplatin plus NAC, NAC alone, and saline were intraperitoneally administered.
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Conclusion & Impact:The rats were anesthetized to study the otoacoustic emissions before and after the experiment.Results: The OAEs were attenuated in the cisplatin group: (-1.31/-4.90), (6.28/4.58), (4.00/0.93), (2.73/-3.74), (2.66/-4.53).The group that received NAC in addition to cisplatin had better OAEs.Conclusion: Cisplatin ototoxicity can be detected by OAE testing in rats, and NAC may reduce the ototoxic effect.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Objective: To investigate the changes in otoacoustic emissions (OAEs) for detecting the ototoxicity of cisplatin and to study the possible preventive effect of N-acetylcysteine (NAC) in cisplatin ototoxicity.Materials and Methods: This study was conducted on 21 Wistar albino rats in four groups. Cisplatin, cisplatin plus NAC, NAC alone, and saline were intraperitoneally administered. The rats were anesthetized to study the otoacoustic emissions before and after the experiment.Results: The OAEs were attenuated in the cisplatin group: (-1.31/-4.90), (6.28/4.58), (4.00/0.93), (2.73/-3.74), (2.66/-4.53).The group that received NAC in addition to cisplatin had better OAEs.Conclusion: Cisplatin ototoxicity can be detected by OAE testing in rats, and NAC may reduce the ototoxic effect.
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Cite This Article
SOMDAŞ, M. A., GÜNTÜRK, İ., AVCI, D., YAZICI, C., BALCIOĞLU, E., ÜNSAL, S., GÜNDÜZ, M. (2016). N-Acetyl Cysteine Reduces Cisplatin Ototoxicity. Erciyes Medical Journal, Cilt: 38 - Sayı: 3, 111–114. https://ajindex.com/articles/201519
Scott P, Griffiths M. A clinical review of ototoxicity. Clinical Otolaryn- gology & Allied Sciences 1994; 19(1): 3-8. [CrossRef] Tokgoz B, Somdas MA, Ucar C, Kocyigit I, Unal A, Sipahioglu MH, et al. Correlation between hearing loss and peritonitis frequency and administration of ototoxic intraperitoneal antibiotics in patients with Continuous Ambulatory Peritoneal Dialysis CAPD. Ren Fail 2010; (2): 179-84. [CrossRef] Rybak L, Ramkumar V. Ototoxicity. Kidney Int 2007; 72(8): 931-5. CrossRef] Lee JE, Nakagawa T, Kim TS, Endo T, Shiga A, Iguchi F, et al. Role of reactive radicals in degeneration of the auditory system of mice fol- lowing cisplatin treatment. Acta Otolaryngol 2004; 124(10): 1131-5. CrossRef] Van Ruijven MW, de Groot JC, Klis SF, Smoorenburg GF. The co- chlear targets of cisplatin: an electrophysiological and morphological time-sequence study. Hear Res 2005; 205(1-2): 241-8. [CrossRef] Hatzopoulos S, Di Stefano M, Albertin A, Martini A. Evaluation of cisplatin ototoxicity in a rat animal model. Ann N Y Acad Sci 1999;: 211-25. [CrossRef] Sockalingam R, Freeman S, Cherny TL, Sohmer H. Effect of high- dose cisplatin on auditory brainstem responses and otoacoustic emis- sions in laboratory animals. Am J Otol 2000; 21(4): 521-7.
Oh SH, Yu WS, Song BH, Lim D, Koo JW, Chang SO, et al. Expres- sion of heat shock protein 72 in rat cochlea with cisplatin-induced acute ototoxicity. Acta oto-laryngologica 2000; 120(2): 146-50. CrossRef] 9. Rybak LP, Husain K, Morris C, Whitworth C, Somani S. Effect of protective agents against cisplatin ototoxicity. Otol Neurotol 2000; 21(4): 513-20. 10. Glissen A, Jaworska M, Orth M, Coffiner M, Maes NP, Cantin AM, et al. Nacystelyn, a novel lysine salt of N-acetylcysteine, to augment cellular antioxidant defence in vitro. Respirator Medicine 1997; 91(3): 159-68. [CrossRef] 11. Rybak LP, Mukherjea D, Jajoo S, Ramkumar V. Cisplatin ototoxicity and protection: clinical and experimental studies. Tohoku J Exp Med 2009; 219(3): 177-86. [CrossRef] 12. Lopez Gonzalez MA, Guerrero JM, Rojas F, Delgado F. Ototoxicity caused by cisplatin is ameliorated by melatonin and other antioxidants. J Pineal Res 2000; 28(2): 73-80. [CrossRef] 13. Campbell K, Meech RP, Rybak LP, Hughes LF. The effect of D-methi-onine on cochlear oxidative state with and without cisplatin adminis-tration mechanisms of otoprotection. J Am Acad Audiol 2003; 14(3): 144-56. 14. Teranishi M, Nakashima T, Wakabayashi T. Effects of alpha-tocoph-erol on cisplatin-ind