Journals / KONURALP TIP DERGİSİ / 2018 / Cilt: 10 - Sayı: 2

Hypothyroidism Secondary To Amiodarone Use

Amiodaron Kullanımına Bağlı Gelişen Hipotiroidi

Pages
253–255
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We present a patient with hypothyroidism due to the use of amiodarone in our case.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Amiodarone is a preferred antiarrhythmia in the treatment of cardiac arrhythmias such as ventricular arrhythmia, paroxysmal supraventricular tachycardia, atrial fibrillation, atrial flutter.
📊
Key Findings & Data:The incidence of amiodarone-induced thyrotoxicosis ranges between 2-12% and the incidence of hypothyroidism ranges between 6-13%.
💡
Conclusion & Impact:We present a patient with hypothyroidism due to the use of amiodarone in our case.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Amiodarone is a preferred antiarrhythmia in the treatment of cardiac arrhythmias such as ventricular arrhythmia, paroxysmal supraventricular tachycardia, atrial fibrillation, atrial flutter. According to the literature, one of the most common and most important side effects is the cause of the thyroid function. In the clinic, the vast majority of patients stay with euthyroidism, some with thyrotoxicosis and some with hypothyroidism. The incidence of amiodarone-induced thyrotoxicosis ranges between 2-12% and the incidence of hypothyroidism ranges between 6-13%. We present a patient with hypothyroidism due to the use of amiodarone in our case.

Özet

Amiodaron,ventriküler aritmi, paroksismal supraventriküler taşikardi, atriyal fibrilasyon, atriyal flutter gibi kardiyak aritmilerin tedavisinde sık tercih edilen bir antiaritmiktir. Literatüre göre en sık ve en önemli yan etkilerinden biri tiroiddisfonksiyonuna sebep olmasıdır. Klinikte ise hastaların büyük çoğunluğu ötiroid kalmakla birlikte bazılarında tirotoksikoz bazılarında ise hipotiroidi tablosu ortaya çıkmaktadır. Amiodarona bağlı tirotoksikoz insidansı %2-12 arasında, hipotiroidi insidansı ise %6-13 arasında değişmektedir. Vakamızda amiodaron kullanımına bağlı hipotiroidi gelişen bir hastayı sunduk..

🔖

Cite This Article

SİVRİTEPE, R., BASAT, S. U., YİĞİT, E., AKTAŞ, H. Ş. (2018). Hypothyroidism Secondary To Amiodarone Use. KONURALP TIP DERGİSİ, Cilt: 10 - Sayı: 2, 253–255. https://ajindex.com/articles/201242

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Salerno DM, Gillingham KJ, Berry DA, et al. A comparison of antiarrhythmic drugs for the suppression of ventricular ectopic depolarizations: a meta-analysis. American heart journal 1990;120(2):340-53.
  2. Basaria S, Cooper DS. Amiodarone and the thyroid. The American journal of medicine 2005;118(7):706-14.
  3. Smyrk TC, Goellner JR, Brennan MD, et al. Pathology of the thyroid in amiodarone-associated thyrotoxicosis. The American journal of surgical pathology, 1987;11(3):197-204.
  4. Charlier R, Delaunois G, Bauthier J, et al. Research on the benzofuran series. XL. Anti-arrhythmic properties of amiodarone. Cardiologia, 1969;54(2): 83-90.
  5. Ünal N, Gürlek A. Amiodaron ve tiroid. Hacettepe Tıp Dergisi 2005; 36:152-6.
  6. Haffajee CI, Love JC, Lesko LJ, et al. Clinical pharmacokinetics and efficacy of amiodarone for refractory tachyarrhythmias. Circulation, 1983; 67(6):1347-55.
  7. Rotmensch HH, Belhassen B, Swanson B, et al. Steady-state serum amiodarone concentrations: relationships with antiarrhythmic efficacy and toxicity. Annals of internal medicine 1984; 101(4):462-9.
  8. Iudica-Souza C, Burch HB. Amiodarone-induced thyroid dysfunction. The Endocrinologist 1999; 9(3):216- 38. Loh KC. Amiodarone-induced thyroid disorders: a clinical review. Postgraduate medical journal 2000; 76(893):133-40. Amiodaron Trials Meta-Analysis Investigators: Effect of prophylactic amiodarone on mortality after acute myocardial infarctionand in congestive heartfailure: metaanalysis of individual data from 6500 patients in randomised trials. Lancet 1997;350:1417-24.
  9. Hohnloser SH, Singh BN. Proarrhythmia with class III antiarrhythmic drugs: definition, electrophysiologic mechanisms, incidence, predisposing factors, and clinical implications. Journal of cardiovascular electrophysiology 1995; 6(10):920-36.
  10. Holt DW, Tucker GT, Jackson PR, et al. Amiodarone pharmacokinetics. American heart journal, 1983; 106(4): 840-7. Amiodaron Available from: http://www.acilci.net/amiodaron
  11. Gopalan M, Burks J. Thyroid Dysfunction Induced by Amiodarone Therapy Available from: https://emedicine.medscape.com/article/129033-overview ERSOY C Ö. Hipotiroidizm tedavisi. Turkiye Klinikleri Journal of Endocrinology Special Topics 2014; 7(3):37-40.
  12. Martino E, Mariotti S, Aghini-Lombardi F, et al. Short term administration of potassium perchlorate restores euthyroidism in amiodarone iodine-induced hypothyroidism. The Journal of Clinical Endocrinology & Metabolism 1986; 63(5):1233-36