Journals / Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi / 2007 / Cilt: 21 - Sayı: 3

Defensins and their roles in H.Pylori infection

Defensinler ve H. pylori enfeksiyonundaki rolleri

Pages
215–221
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Studies on this subject might help to enlight the pathogenesis of H. pylori infection in the future

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Immune system is divided into two groups as innate and acquired.
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Key Findings & Data:It is known that defensin level increases in H. pylori infection and decreases with eradication.
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Conclusion & Impact:Studies on this subject might help to enlight the pathogenesis of H. pylori infection in the future
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Çocuk · Helicobacter pylori · Defensin

Abstract

Immune system is divided into two groups as innate and acquired. In¬nate immune system, different from the acquired immune system, pro¬vides a quick and permanent pro¬tection against first met pathogens. The main members of this system are anatomic barriers, secretory molecules and cellular components. Leading examples of antimicrobial peptides, an important part of innate immune system, in mammals are defensins. These peptides take place in H. pylori infection like they do in many other infections. It is known that defensin level increases in H. pylori infection and decreases with eradication. On the other hand, the role of these peptides is still not clearly displayed. Studies on this subject might help to enlight the pathogenesis of H. pylori infection in the future

Özet

Bağışıklık sistemi doğuştan ve edinsel olmak üzere iki gruba ayrılır. Doğuştan bağışıklık sistemi, edinselden farklı olarak daha önce karşılaşmadığı patojenlere karşı hızlı ve devamlı koruma sağlar. Bu sistemin başlıca üyeleri anatomik engeller, salgısal moleküller ve hücresel bileşenlerdir. Doğuştan bağışıklık sisteminin önemli bir parçası olan antimikrobiyal peptidlerin memeliler¬deki başlıca örnekleri ise defensinlerdir. Bu peptitler birçok enfeksiyonda olduğu gibi H. pylori enfeksiyonunda da görev almaktadırlar. H. pylori enfeksiyonunda defensin düzeyinin arttığı ve eradikasyonla azaldığı bilinmektedir. Ancak bu peptidlerin rolü halen net olarak ortaya konamamıştır. İleride bu konuda yapılacak çalışmalar H. pylori enfeksiyonunun patogenezini aydınlatmada yardımcı olabilir.

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Cite This Article

SOYLU, B. Ö., ÖZTÜRK, Y. (2007). Defensins and their roles in H.Pylori infection. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi, Cilt: 21 - Sayı: 3, 215–221. https://ajindex.com/articles/200130

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