Journals / İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi / 2017 / Cilt: 7 - Sayı: 2

Measles-rubella-mumps vaccination in cases with egg allergy: Is skin prick test necessary? Can vaccination be done safely?

Yumurta allerjisi olan olgularda kızamık-kızamıkçık-kabakulak aşılaması öncesi aşı ile deri prick testi gerekli mi? Aşı güvenle yapılabilir mi?

Pages
129–132
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Since we didn't observe any reaction in these patients different from that seen in other healthy children, we think that there is no containdication for administering MMR vaccines at the centers in which the other vaccines were done, without any need to administer MMR vaccine with prick test or in divided doses.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Measles-mumps- rubella vaccine which contains egg protein is considered as a potential allergen in children with egg allergy and although administration of the vaccine without any evaluation in egg allergic patients is suggested, due to the presence of reported cases of anaphylaxis during vaccination in the literature this issue causes distress to both families and doctors.
📊
Key Findings & Data:Methods: In our study, 82 patients followed up with the diagnosis of egg allergy diagnosis and administered MMR vaccine between September 2013 and May 2015 were included in retrospective cross-sectional study.
💡
Conclusion & Impact:Since we didn't observe any reaction in these patients different from that seen in other healthy children, we think that there is no containdication for administering MMR vaccines at the centers in which the other vaccines were done, without any need to administer MMR vaccine with prick test or in divided doses.
🔬Design:Research Article
📍Scope:2013 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Measles-mumps- rubella vaccine which contains egg protein is considered as a potential allergen in children with egg allergy and although administration of the vaccine without any evaluation in egg allergic patients is suggested, due to the presence of reported cases of anaphylaxis during vaccination in the literature this issue causes distress to both families and doctors. In this study the frequency of reactions observed after MMR vaccination and the necessity of skin prick test in the patients followed up with egg allergy in our clinic were evaluated. Methods: In our study, 82 patients followed up with the diagnosis of egg allergy diagnosis and administered MMR vaccine between September 2013 and May 2015 were included in retrospective cross-sectional study. Results: The average age was 8.34±7.1 months, and 37.8% (n=31) of the cases were female. According to their diagnostic distribution, the patients had atopic dermatitis (n=56; 68.3%) had, urticaria/angioedema (n=7; 8.5%), reactive airway disease (n=15; 18.3%), and anaphylaxis (n=9; 4.9%). Skin prick test was administered to 17 (21%) patients before MMR vaccination. A whole dose of vaccine was administered to all cases except in two cases with the diagnosis of anaphylaxis. There was no reaction observed after MMR vaccination in any of the cases. Conclusion: Any reaction was not observed in any of egg allergy cases after MMR vaccination. Since we didn't observe any reaction in these patients different from that seen in other healthy children, we think that there is no containdication for administering MMR vaccines at the centers in which the other vaccines were done, without any need to administer MMR vaccine with prick test or in divided doses.

Özet

Amaç: İçerisinde yumurta proteini bulunan kızamık-kızamıkçık-kabakulak aşısının (KKK) yumurta alerjisi olan hastalarda doğrudan uygulanması önerilmesine karşın literatürde aşı uygulaması sırasında anaflaksi gözlenen olguların bulunması nedeniyle bu konu hem hekim hem de ailelerde sıkıntılara neden olmaktadır. Bu çalışmada, kliniğimizde yumurta alerjisi nedeniyle izlenen, KKK aşı uygulanmış hastalarda aşı sonrası reaksiyon sıklığının ve aşı uygulaması öncesi aşı ile deri prick test uygulamasının gerekliliğinin değerlendirilmesi amaçlanmıştır.Yöntem: Retrospektif kesitsel çalışmamızda Eylül 2013-Mayıs 2015 tarihleri arasında yumurta alerjisi tanısı ile izlenip, KKK aşısı uygulanmış olan 82 hasta değerlendirildi. Bulgular: Tanı anında yaş ortalaması 8,34±7,1ay olan 82 hastanın %37,8'i (n=31) kız idi. Tanısal dağılımına göre hastalar değerlendirildiğinde, %68,3'ü (n=56) atopik dermatit, %8,5'i (n=7) ürtiker/anjioödem, %18,3'ü (n=15) reaktif havayolu hastalığı, %4,9'u (n=4) anafilaksi olarak değerlendirilmişti. KKK aşı uygulaması öncesi %21'ine (n=17) aşı ile deri prick test uygulanmıştı. Anafilaksi tanısı ile izlenen 2 olgu dışında aşı tam doz yapılmış olup, olguların hiçbirinde KKK aşısı uygulaması sonrasında reaksiyon gözlenmemişti. Sonuç: Yumurta alerjili hastalarda KKK aşısı sonrası herhangi bir reaksiyon gözlenmemiştir. Bu hastalarda diğer sağlıklı çocuklardan farklı reaksiyonlar gözlemediğimiz için KKK aşısının diğer aşıların yapıldığı merkezlerde, aşı ile teste ve bölünmüş dozlara gerek kalmadan uygulanmasında sakınca olmadığını düşünüyoruz.

🔖

Cite This Article

BAHÇECİ, S., NACAROĞLU, H. T., ARI, H. F., KARAMAN, S., KARKINER, C. Ş., KANIK, E. T., CAN, D. (2017). Measles-rubella-mumps vaccination in cases with egg allergy: Is skin prick test necessary? Can vaccination be done safely?. İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi, Cilt: 7 - Sayı: 2, 129–132. https://ajindex.com/articles/199894

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Toit G du, Tsakok T, Lack S, et al. Prevention of food allergy. J Allergy Clın Immunol 137(4):998-1010.
  2. Jessadapakorn W, Sangsupawanich P, Wootipoom N, Suddeaugrai O, Yuenyongviwat A. Component-resolved diagnostics in Thai children with cow's milk and egg allergy. Asian Pac J Allergy Immunol DOI 10.12932/AP0820.
  3. Rona RJ, Keil T, Summers C, Gislason D, et al. The prevalence of food allergy: a meta-analysis. J Allergy Clin İmmunology 2007;120:638-46.
  4. Cerecedo Carballo I, Dieguez Pastor MC, Bartolomé Zavala B, et al. Safety of measles-mumps-rubella vaccine (MMR) in patients allergic to eggs. Allergol et Immunopathol 2007;35(3):105-9.
  5. Dreskin SC, Halsey NA, Kelso JM, et al. International Consensus (ICON): allergic reactions to vaccines. World Allergy Organization Journal 2016;9:32.
  6. Dumortier B, Nosbaum A, Ponvert C, Nicolas JF, Bérard F. Measles-Mumps-Rubella vaccination of an egg-allergic child sensitized to gelatin. Arch Pediatr 2013;20(8):867-70. Epub 2013 Jul 11.
  7. Freitas DR, Moura E, Araújo G, Cardoso A, et al. Investigation of an outbreak of hypersensitivity-type reactions during the 2004 national measles-mumps-rubella vaccination campaign in Brazil. Vaccine 2013;31(6):950-4
  8. Fina Avilés F, Campins Martí M, Martínez Gómez X, et al. MMR vaccine and egg allergy. Experience in a hospital immunization unit. An Pediatr (Barc) 2007;67(4):362-7.
  9. Patja A, Davidkin I, Kurki T, Kallio MJ, Valle M, Peltola H. Serious adverse events after measles-mumps-rubella vaccination during a fourteen-year prospective follow-up. Pediatr Infect Dis J 2000;19(12):1127-34.
  10. Nicoline A. T. van der Maas, T. Woudenberg, S. J. M. Hahné, and H. E. de Melker. Tolerability of Early Measles-MumpsRubella Vaccination in Infants Aged 6-14 Months During a Measles Outbreak in The Netherlands in 2013-2014. J Infect Dis 2016;213(9):1466-1471.
  11. Baxter DN. Measles immünization in children with a history of egg allergy. Vaccine 1996;14:131-134.
  12. Khakoo G A, Lack G. Recommendations for using MMR vaccine in children allergic to eggs. BMJ 2000;320(7239):929-