Journals / Gülhane Tıp Dergisi / 2015 / Cilt: 57 - Sayı: 2

Yönlendirilmiş Kemik Rejenerasyonu İçin Yeni Bir Trombositten Zengin Ürün: Titanyum Destekli Trombositten Zengin Fibrin

A novel platelet concentrate for guided bone regeneration: Titanium Prepared Platelet-Rich Fibrin (T-PRF)

Pages
102–106
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Basing on the results of this study, we can say that T-PRF membrane can be successfully used for bone augmentation

📌 3 Key Takeaways

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Objective & Hypothesis:In our previous studies, we developed a novel platelet-rich product that we called titaniumprepared platelet-rich fibrin (T-PRF).
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Key Findings & Data:Half of the animals were sacrificed after one month, and the remaining animals were sacrificed 3 months later.
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Conclusion & Impact:Basing on the results of this study, we can say that T-PRF membrane can be successfully used for bone augmentation
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In our previous studies, we developed a novel platelet-rich product that we called titaniumprepared platelet-rich fibrin (T-PRF). T-PRF is based on the hypothesis that titanium may be more effective at activating platelets than the silica activators used with glass tubes in Chouckroun's platelet-rich fibrin (PRF). This study aimed to assess the effects of T-PRF on bone augmentation in a rabbit calvaria model. Twenty-four adult male New Zealand rabbits were used in the study. T-PRF alone, inorganic bovine bone (ABB), and T-PRF + ABB were used in the experimental groups. No material was used in the control group. Half of the animals were sacrificed after one month, and the remaining animals were sacrificed 3 months later. A histomorphometric evaluation was performed to compare new bone formation among the groups. More new bone areas were determined in the T-PRF group than the other three groups. While less new bone formation was observed than in the T-PRF group, more new bone formation occurred in the ABB and T-PRF + ABB groups when compared to the control group. Basing on the results of this study, we can say that T-PRF membrane can be successfully used for bone augmentation

Özet

Önceki çalışmalarımızda, titanyum destekli trombositten zengin fibrin (T-PRF) olarak adlandırdığımız yeni bir trombositten zengin ürün geliştirdik. T-PRF fikri Chouckroun'un trombositten zengin fibrininde (PRF) titanyumun, trombositlerin aktivasyonunda cam tüplerdeki silika aktivatörlerden daha etkili olabileceği hipotezinden doğdu. Bu çalışmanın amacı T-PRF'nin kemik ogmentasyonundaki etkinliğini, tavşan kafatası modelinde değerlendirmektir. Çalışmada yirmi dört adet yetişkin erkek Yeni Zellanda tavşanı kullanılmıştır. Tek başına T-PRF, inorganik sığır kaynaklı kemik grefti (ABB) ve T-PRF + ABB ü deneysel gruplarda kullanılmışlardır. Kontrol grubunda hiçbir materiyal kullanılmamıştır. Deney hayvanlarının yarısı 1 ay sonra, diğer yarısı ise 3 ay sonra sakrifiye edilmiştir. Gruplardaki yeni kemik oluşumunu karşılaştırmak amacı ile histomorfometrik değerlendirme yapılmıştır. Diğer üç gruba göre T-PRF grubunda daha fazla yeni kemik alanları belirlenmiştir. T-PRF grubuna göre daha az yeni kemik oluşumu görülmesine ragmen, ABB ve T-PRF+ABB gruplarında, kontrol grubu ile karşılaştırıldıklarında, daha fazla yeni kemik oluşumu gözlenmiştir. Bu çalışmanın sonuçlarına dayanarak, T-PRF membranın kemik ogmentasyonunda başarılı bir şekilde kullanılabilir olduğunu söyleyebiliriz

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Cite This Article

TUNALI, M., ÖZDEMİR, H., KÜÇÜKODACI, Z., EZİRGANLI, Ş., BARIŞ, E., AKMAN, S., ATAY, A., FIRATLI, H. E. (2015). Yönlendirilmiş Kemik Rejenerasyonu İçin Yeni Bir Trombositten Zengin Ürün: Titanyum Destekli Trombositten Zengin Fibrin. Gülhane Tıp Dergisi, Cilt: 57 - Sayı: 2, 102–106. https://ajindex.com/articles/199791

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