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Journals / Haydarpaşa Numune Medical Journal / 2020 / Cilt: 60 - Sayı: 3

The Role of TNF-alpha and IL-10 Cytokines in Degenerative Lumbar Spinal Stenosis

Mustafa EFENDİOĞLU
Emine Emel KOÇMAN
Pages
250–253
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The inflammatory process of the disease is trying to be balanced with an anti-inflammatory response.

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: In this study, we investigated Tumor Necrosis Factor-α (TNF-α)/Interleukin -10 (IL-10) (inflammatory/anti-inflammatory) cytokine balance in patients diagnosed with degenerative Lumbar Spinal Stenosis (LSS).
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Key Findings & Data:Methods: Blood samples obtained from patients and control subjects were centrifuged at the Haydarpaşa Numune Training and Research Hospital Immunology Laboratory and stored at -20°C.
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Conclusion & Impact:The inflammatory process of the disease is trying to be balanced with an anti-inflammatory response.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Introduction: In this study, we investigated Tumor Necrosis Factor-α (TNF-α)/Interleukin -10 (IL-10) (inflammatory/anti-inflammatory) cytokine balance in patients diagnosed with degenerative Lumbar Spinal Stenosis (LSS). Methods: Blood samples obtained from patients and control subjects were centrifuged at the Haydarpaşa Numune Training and Research Hospital Immunology Laboratory and stored at -20°C. Human TNF-alpha and IL-10 cytokines were studied manually with an Enzyme-linked immunosorbent assay (ELISA) method using Boster brand 96-well ELISA kits. Results: TNF -alpha values of the patient group were found to be statistically significantly higher than the control group (p=0.004; p<0.05) and IL-10 values of the patient group were statistically significantly higher than the control group (p=0.017; p<0.05). Discussion and Conclusion: Our findings suggest that TNF-alpha and IL-10 cytokine levels increased together in degenerative LSS cases. The inflammatory process of the disease is trying to be balanced with an anti-inflammatory response.

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Cite This Article

EFENDİOĞLU, M., KOÇMAN, E. E. (2020). The Role of TNF-alpha and IL-10 Cytokines in Degenerative Lumbar Spinal Stenosis. Haydarpaşa Numune Medical Journal, Cilt: 60 - Sayı: 3, 250–253. https://ajindex.com/articles/199681

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