Journals / Çocuk Acil ve Yoğun Bakım Dergisi / 2016 / Cilt: 3 - Sayı: 3

Successful Intravenous Lipid Infusion Therapy in a Case with Life-Threatening Calcium Channel and Beta Blockers Overdose

Hayatı Tehdit Eden Kalsiyum Kanal Blokeri ve Beta Bloker Zehirlenme Olgusunda Başarılı İntravenöz Lipit İnfüzyon Tedavisi

Pages
151–154
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

With this report, we aimed to draw attention to those intoxications that can be life-threatening and emphasize that intravenous lipid infusion therapy can be successful in patients refractory to other treatments.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Life-threatening cardiovascular collapse symptoms can develop due to calcium channel and beta-receptor blocker overdose and there are no specific antidotes for treatment.
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Key Findings & Data:A 13-year-old girl was admitted with severe hypotension and bradycardia after ingestion of an overdose carvedilol and verapamil.
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Conclusion & Impact:With this report, we aimed to draw attention to those intoxications that can be life-threatening and emphasize that intravenous lipid infusion therapy can be successful in patients refractory to other treatments.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Life-threatening cardiovascular collapse symptoms can develop due to calcium channel and beta-receptor blocker overdose and there are no specific antidotes for treatment. A 13-year-old girl was admitted with severe hypotension and bradycardia after ingestion of an overdose carvedilol and verapamil. Cardiovascular collapse was resistant to fluid therapy, calcium gluconat and high-dose vasopressor infusion. Intravenous lipid infusion was administered in the patient who had resistant hypotension with hiperinsulinemic euglycemia on the first hour of hospitalization. Hemodynamic stability of the patient was achieved 30 minutes after lipid administration. Calcium channel and beta-receptor blocker overdose may result in life-threatening intoxication. Classical therapies suggested for these intoxications can be insufficient. Favorable results can be obtained after intravenous lipid infusion. With this report, we aimed to draw attention to those intoxications that can be life-threatening and emphasize that intravenous lipid infusion therapy can be successful in patients refractory to other treatments.

Özet

Kalsiyum kanal ve beta reseptör blokerleri ile olan zehirlenmelerde hayatı tehdit edici kardiyovasküler kollaps bulguları gelişebilmekte ve tedavi için özgül bir antidot bulunmamaktadır. On üç yaşında kız olgu, aşırı doz karvedilol ve verapamil alımını takiben ciddi hipotansiyon ve bradikardi bulguları ile getirildi. Kardiyovasküler kollaps tablosu sıvı tedavisi, kalsiyum glukonat ve yüksek doz vasopressör infüzyonuna dirençli idi. Hiperinsülinemik öglisemi tedavisi ile de dirençli hipotansiyonu devam eden olguya intravenöz lipit infüzyonu izleminin 1. saatinde uygulandı. Olgunun hemodinamik stabilitesi lipit uygulamasından yarım saat sonra sağlandı. Kalsiyum kanal ve beta reseptör blokerleri ile olan zehirlenmeler, hayatı tehdit edebilen zehirlenmelerdir. Bu zehirlenmelerde önerilen klasik destek tedavileri yetersiz kalabilmekte, intravenöz lipit infüzyonu ile başarılı sonuçlar alınabilmektedir. Biz de bu olgu ile hayati tehlike yaratabilen bu zehirlenmelere tekrar dikkat çekmek ve diğer tedavilere yanıtsız olgularda intravenöz lipit infüzyonu tedavisinin başarılı olabileceğini vurgulamak istedik.

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Cite This Article

DURAK, F., CAN, F. K., ZENGİN, N., DURAK, İ., YILDIZ, K., ANIL, A. B. (2016). Successful Intravenous Lipid Infusion Therapy in a Case with Life-Threatening Calcium Channel and Beta Blockers Overdose. Çocuk Acil ve Yoğun Bakım Dergisi, Cilt: 3 - Sayı: 3, 151–154. https://ajindex.com/articles/199628

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