Journals / Anestezi Dergisi / 2010 / Cilt: 18 - Sayı: 2

Comparison of the effects of prophylactic prehydration or ephedrine administration for spinal anesthesia on hemodynamic parameters and QT interval

Spinal anestezide profilaktik prehidrasyon ve efedrin uygulamalarının hemodinamik parametreler ile QT intervali üzerine etkilerinin karşılaştırılması

Pages
68–73
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Both methods could be performed depending on the patient's clinic and preference of the anesthesiologist.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To prevent spinal anesthesia induced hypotension, the effects of intravenous ephedrine and colloid prehydration on the hemodynamic parameters and QTc interval were compared.
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Key Findings & Data:Method: After ethic committee approval, ASA I-II, 60 patients scheduled for arthroscopic knee surgery were randomly allocated into two groups.
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Conclusion & Impact:Both methods could be performed depending on the patient's clinic and preference of the anesthesiologist.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: To prevent spinal anesthesia induced hypotension, the effects of intravenous ephedrine and colloid prehydration on the hemodynamic parameters and QTc interval were compared. Method: After ethic committee approval, ASA I-II, 60 patients scheduled for arthroscopic knee surgery were randomly allocated into two groups. Before and after the anesthesia, blood pressures and heart rates were recorded. ECG recordings were used to measure the QTc intervals. In Group K, prehydration was performed with 500 mL 6% HES before spinal anesthesia. In Group E, ephedrin 15 mg iv was administered after spinal anesthesia. Five mg bolus ephendine was applied in case of hypotension. Results: The blood pressures, heart rates and hypotension incidence were similar among the groups (p>0.05). QTc intervals of both groups were extended after the spinal anesthesia (p<0.001), but the differences were not significant among the groups (p>0.05). Although intraoperative and postoperative intravenous fluid was similar in both groups (p>0.05), the first voiding time was earlier in Group K than Group E (p<0.01). Conclusion: The effects of prehydration with colloid and intravenous ephedrine for spinal anesthesia-induced hypotension have similar effect on hemodynamic parameters and QTc interval. Both methods could be performed depending on the patient's clinic and preference of the anesthesiologist.

Özet

Amaç: Spinal anesteziye bağlı hipotansiyonu önlemede intravenöz efedrin uygulaması ile kolloid prehidrasyonunun hemodinamik parametreler ve QTc intervaline etkilerini karşılaştırmayı amaçladık. Yöntem: Etik komite izni alınan, artroskopik diz cerrahisi uygulanacak ASA I-II, 60 olgu randomize olarak 2 gruba ayrıldı. Olguların anestezi öncesi ve sonrası kan basınçları, kalp atım hızı, EKG kaydı alınarak QTc intervalleri kaydedildi. Grup K'ya spinal anestezi öncesi 500 mL %6 HES ile prehidrasyon; Grup E'ye spinal anestezi sonrası 15 mg iv efedrin uygulandı. Hipotansiyon, 5 mg iv efedrin ile tedavi edildi. Bulgular: Spinal anestezi sonrası kan basıncı, kalp hızları ve hipotansiyon sıklığı gruplarda benzer seyretti (p>0.05). QTc intervali spinal anestezi sonrası her iki grupta da uzamakla beraber (p 0.05). İntraoperatif ve postoperatif verilen sıvı miktarları her iki grupta da benzer (p>0.05) olmasına rağmen ilk miksiyon zamanı Grup K'da Grup E'den daha erken izlendi (p<0.01). Sonuç: Spinal anesteziye bağlı hipotansiyon profilaksisi amacı ile kolloid ile prehidrasyon ve intravenöz efedrin uygulamalarının hemodinamik parametreler ve QTc intervali üzerine etkilerinin benzer olduğu gözlendi. Her iki yöntemin de olgunun kliniğine ve anestezistin tercihine göre uygulanabileceği görüşündeyiz.

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Cite This Article

AYDIN, S., ÖZLÜ, O., AKSOY, M. (2010). Comparison of the effects of prophylactic prehydration or ephedrine administration for spinal anesthesia on hemodynamic parameters and QT interval. Anestezi Dergisi, Cilt: 18 - Sayı: 2, 68–73. https://ajindex.com/articles/199527

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References (14)

  1. Kayhan Z. Klinik Anestezi. İstanbul, Logos Yayıncılık Tic. A.Ş. 2004
  2. Morgan GE, Mikhail MS, Murray MJ. Spinal, epidural ve kaudal bloklar. Çeviri: Ateş Y. In: Morgan GE, Mikhail MS, Murray MJ (eds) Klinik Anesteziyoloji, Çeviri Editörü: Tulunay M, Cuhruk H. Ankara, Güneş Tıp Kitabevleri 2008
  3. Morgan P. The role of vasopressors in the management of hypotension induced by spinal and epidural anaesthesia. Can J Anaesth 1994
  4. Baraka AS, Taha SK, Ghabach MB, Sibaii A, Nader AM. Intravascular administration of polymerized gelatin versus isotonic saline for prevention of spinal-induced hypotension. Anesth Analg 1994
  5. French GW, White JB, Howell S J, Popat M. Comparison of pentastarch and Hartmann's solution for volume preloading in spinal anaesthesia for elective caesarean section. Br J Anaesth 1999
  6. Youngs PJ, Littleford J. Arrhythmias during spinal anesthesia. Can J Anaesth 2000
  7. Owczuk R, Sawicka W, Wujtewicz MA, Kawecka A, Lasek J, Wujtewicz M. Influence of spinal anesthesia on corrected QT interval. Reg Anesth Pain Med 2005
  8. Adamson PB, Suarez J, Ellis E, Kanaly T, Vanoli E. Ephedrine increases ventricular arrhythmias in conscious dogs after myocardial infarction. J Am Coll Cardiol 2004
  9. Gedevanishvili A, Chamoun A, Uretsky BF, Rahman AM. Acute coronary syndrome induced by intravenous ephedrine in pregnant woman with normal coronaries. Can J Clin Pharmacol 2004
  10. e 195-8. 10.McBride BF, Karapanos AK, Krudysz A, Kluger J, Coleman CI, White CM. Electrocardiographic and hemodynamic effects of a multicomponent dietary supplement containing ephedra and caffeine: a randomized controlled trial. JAMA 2004
  11. Kaymank Ç,Doğru T,Başar H.Laparoskopik kolesistektomi cerrahisinde sevofluran ve desfluran anestezisinin QTc intervali QT dispersiyon, aritmi oluşumu ve kalp hızı değişkenliği üzerine etkisi.Türk Anest Rean Der Dergisi 2007
  12. Collins VJ. Spinal analgesia physiologic effects. In: VJ Collins (ed.) Principles of Anesthesiology. 3rd edition. Philadelphia: Lea & Febiger
  13. Ölmez G, Öztekin MH. Spinal anesteziye bağlı hipotansiyonun önlenmesi: anestezi öncesi kolloid ve kristaloid ön yüklemesinin prehidrasyon uygulanmayan grupla karşılaştırılması. Dicle Tıp Dergisi 2006
  14. Karinen J, Rasanen J, Alahuhta S, Jouppila R, Jouppila P. Effect of crystalloid and colloid preloading on uteroplacental and maternal h