Journals / KBB-Forum / 2011 / Cilt: 10 - Sayı: 4

The use of c-reactive protein, procalcitonin and erythrocyte sedimentation rate in clinical practice

C-reaktif protein, prokalsitonin ve eritrosit sedimantasyon hızı'nın klinik pratikte kullanımı

Journal
KBB-Forum
Pages
70–73
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This study looks at the appropriate use and importance of these acute-phase reactants in clinical practice.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:C-Reactive Protein (CRP), Erythrocyte Sedimentation Rate (ESH) and Procalcitonin (PCT) are the most frequently ordered tests in outpatient, emergency room and inpatient settings.
📊
Key Findings & Data:The correct interpretation of these acute-phase reactants are important when differentiating between viral and bacterial infections when serious infections are present, identifying non-infectious inflammations, monitoring response to treatment and managing inappropriate antibiotic use.
💡
Conclusion & Impact:This study looks at the appropriate use and importance of these acute-phase reactants in clinical practice.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

C-Reactive Protein (CRP), Erythrocyte Sedimentation Rate (ESH) and Procalcitonin (PCT) are the most frequently ordered tests in outpatient, emergency room and inpatient settings. The correct interpretation of these acute-phase reactants are important when differentiating between viral and bacterial infections when serious infections are present, identifying non-infectious inflammations, monitoring response to treatment and managing inappropriate antibiotic use. This study looks at the appropriate use and importance of these acute-phase reactants in clinical practice.

Özet

Gerek polikliniklerde, gerekse acillerde ve servislerde en çok istenen tetkikler arasında C-reaktif protein (CRP), eritrosit çökme hızı (ESH) ve giderek artan oranda prokalsitonin (PCT) gelmektedir. Ciddi enfeksiyonların varlığı, takibi, viral ve bakteriyel enfeksiyonların ayırımı yanı sıra, non-enfeksiyoz inflamasyonların belirlenmesinde, tedaviye yanıtın izlenmesinde, yersiz ve uzun süreli antibiyotik kullanımını yönetmede bu akut faz reaktanlarının doğru yorumlanması önemlidir. Akut faz reaktanı olarak bilinen bu testlerin klinik pratikteki yeri ve önemini tartışmayı amaçladık.

🔖

Cite This Article

YAZGAN, H., YAZGAN, Z., UZUN, L., GÜREL, A. (2011). The use of c-reactive protein, procalcitonin and erythrocyte sedimentation rate in clinical practice. KBB-Forum, Cilt: 10 - Sayı: 4, 70–73. https://ajindex.com/articles/199408

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Khera A, McGuire DK, Murphy SA, Stanek HG, Vongpatanasin W, Wians FH, Grundy SM, Lomes JA. Race and gender differences in C-reactive protein levels. J Am Coll Cardiol. 2005;46(3):464–469
  2. Baumann H, Gauldie J. The acute phase response. Immunology Today 1994; 15(2): 74-80
  3. Yaylı G. İnfeksiyon hastalıklarında C-reaktif protein, sedimantasyon ve lokositler. Ankem Derg. 2005; 19(Suppl. 2): 80-4
  4. Saez-Lorens X, Lagrutta F. The acute phase reaction during bacterial infection and its clinical impact in children. Pediatr Infect Dis J. 1993; 12(1): 83-7
  5. Batırel A, Gencer S, Ozer S. Enfeksiyon göstergesi olarak akut faz reaktanları: C-reaktif protein (CRP) ve serum amiloid A (SAA). Kartal Eğitim ve Araştırma Hastanesi Tıp Dergisi. 2003; 14(3):220-4
  6. Gruys E, Toussaınt M.J.M., Nıewold T.A., Koopmans S.J. Acute phase reaction and acute phase proteins. J Zhejiang Univ SCI 2005 6B(11):1045-1056 7. Meier-Ewert HK, Ridker PM, Rifai N, Dinges DF, Mullington JM. Absence of diurnal variation of C-reactive protein concentrations in healthy human subjects. Clin Chem 2001; 47: 426-30
  7. Pepys MB, Hirschfield GM. C-reactive protein: a critical update. J Clin Invest. 2003;111(12):1805–1812
  8. Vermeire S, Van Assche G, Rutgeerts P. The role of Creactive protein as an inflammatory marker in gastrointestinal diseases. Nat Clin Pract Gastroenterol Hepatol. 2005;2(12):580–586
  9. Hamm CW, Nef HM, Rolf A, Möllmann H. Calcium and Creactive protein. J Am Coll Cardiol 2011; 57:465-467
  10. Mahmoud FA, Rivera NI: The role of C-reactive protein as a prognostic indicator in advanced cancer. Curr Oncol Rep 2002;4(3):250-5
  11. Cermak J, Key NS, Bach RR, et al. C-reactive protein induces human peripheral blood monocytes to synthesize tissue factor. Blood 1993;82:513
  12. Jones SA, Novick D, Horiuchi S, et al. C-reactive protein: a physiological activator of interleukin 6 receptor shedding. J Exp Med 1999; 189:599
  13. Volanakis JE. Human C-reactive protein: expression, structure, and function. Mol Immunol 2001; 38:189
  14. Vanderschueren S, Deeren D, Knockaert DC, et al. Extremely elevated C-reactive protein. Eur J Intern Med 2006; 17:430
  15. Pečavar B, Nadrah K, Papst L, Ceč V, Kotar T, Matičič M, Meglič-Volkar J, Vidmar L, Beović B.Clinical characteristics of adult patients with influenza-like illness hospitalized in general ward during Influenza A H1N1 pandemic 2009/2010. Wien Klin Wochenschr. 2011 Sep 22. [Epub ahead of print] 17. Kono T, Otsuka M. Negative C-reactiv