Journals / İzmir Tepecik Eğitim Hastanesi Dergisi / 2018 / Cilt: 28 - Sayı: 2

Bullous hemorrhagic dermatosis associated with low-molecular weight heparin: A case report

Düşük molekül ağırlıklı heparine bağlı büllöz hemorajik dermatoz: Olgu sunumu

Pages
131–134
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We found it appropriate to present our case with this rare adverse effect of LMWHs.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Currently, low-molecular weight heparins (LMWHs) are frequently used for the prophylaxis and treatment of pulmonary thromboembolism (PTE).
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Key Findings & Data:LMWH shows its anticoagulatory effect through the activation of antitrombin III and the inactivation of Factor Xa.
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Conclusion & Impact:We found it appropriate to present our case with this rare adverse effect of LMWHs.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Currently, low-molecular weight heparins (LMWHs) are frequently used for the prophylaxis and treatment of pulmonary thromboembolism (PTE). LMWH shows its anticoagulatory effect through the activation of antitrombin III and the inactivation of Factor Xa. Its major side/adverse effects are bleeding, heparin-induced thrombocytopenia, hepatotoxicity, osteoporosis and skin reactions. In comparison to the more common skin reactions such as urticeria, itching, dermatitis, erythema; its rarely seen adverse effect is bullous hemorrhagic dermatosis. We found it appropriate to present our case with this rare adverse effect of LMWHs.

Özet

Günümüzde düşük molekül ağırlıklı heparinler, pulmoner tromboemboli (PTE) profilaksisi ve tedavisinde sıkça kullanılmaktadır. DMAH ise antitrombin III aktivasyonu ile Faktör- Xa’ yı inaktive ederek antikoagülan etkisini gösterir. Başlıca yan etkileri; kanama komplikasyonları, heparin-induced trombositopeni, karaciğer toksisitesi, osteoporoz ve cilt reaksiyonlarıdır. DMAH’ lerin ürtiker, kaşıntı, egzema, eritem gibi cilt yan etkilerine göre çok daha nadir görülen bir yan etkisi de bülloz hemorajik dermatozdur. DMAH’ lerin bu nadir yan etkisini gördüğümüz olgumuzu sunmayı uygun bulduk.

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Cite This Article

GÜLDAVAL, F., YAVUZ, M. Y., ALICI, İ. O., TUNÇOK, S., ERMETE, S., BÜYÜKŞİRİN, M., ANAR, C. M. (2018). Bullous hemorrhagic dermatosis associated with low-molecular weight heparin: A case report. İzmir Tepecik Eğitim Hastanesi Dergisi, Cilt: 28 - Sayı: 2, 131–134. https://ajindex.com/articles/199212

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