AI Summary & Key Takeaways
AI InsightObesity and increased estrogen levels may be contributing risk factors for developing endometrial polyps in women over 40 years of age.
📌 3 Key Takeaways
Abstract
STUDY DESIGN: We designed a retrospective study among reproductive age women who were man- aged at our clinic with the diagnosis of endometrial polyps. Thirty seven women older than 40 years of age (study group), and 113 women younger than 40 years (control group) were compared in terms of various clinical and laboratory parameters including age, body mass index (BMI), gravidity, parity, abor- tion, basal hormone levels, tumor markers, complete blood count values, smoking status, presence of polycystic ovary syndrome (PCOS), infertility status, co-morbidities, and number and size of endometrial polyps. RESULTS: The mean age of patients in the study and control groups were 45.2±3.5 and 30.6±4.9 years, respectively (p<0.001). The median BMI, gravidity, parity and abortion were significantly higher in study group (p<0.05). Infertility was more common in control group (65.5% vs. 10.8%; p<0.001). Fasting plasma glucose, basal FSH (follicle stimulating hormone) and estradiol (E2 ) levels were higher in study group than control group (p<0.05). Mean tumor marker levels were similar in both groups. Complete blood count values, smoking status, presence of PCOS, and number and size of polyps did not differ significantly between the two groups. The most common location of endometrial polyps within the uter- ine cavity was the posterior wall. There was no correlation between number and size of polyps and basal hormone levels (p>0.05). CONCLUSION: According to this study, 40 years of age and older women with endometrial polyps were more obese and had higher basal FSH and E2 levels. Obesity and increased estrogen levels may be contributing risk factors for developing endometrial polyps in women over 40 years of age.
Özet
AMAÇ: Endometriyal polibi olan orta ve ileri üreme çağındaki kadınlarda klinik ve laboratuvar parametrelerinin karşılaştırılması. GEREÇ VE YÖNTEM: Endometriyal polip nedeniyle kliniğimizde tedavi edilen üreme çağındaki kadınlardan oluşan retrospektif bir çalışma tasarladık. Kırk yaş ve üzeri 37 kadın (çalışma grubu), 113 kırk yaş altındaki kadınla (kontrol grubu) yaş, vücut kitle indeksi (VKİ), gravide, parite, düşük sayısı, bazal hormon seviyeleri, tümör belirteçleri, tam kan sayımı değerleri, sigara kullanma durumu, polikistik over sendromu (PKOS) varlığı, ek hastalıklar ve polip sayısı ve çapı dahil çeşitli klinik ve laboratuvar parametreler açısından karşılaştırıldı. BULGULAR: Çalışma grubunda ortalama yaş 45,2±3,5 iken kontrol grubunda 30,6±4,9 yıldı (p 0,05). SONUÇ: Çalışmamıza göre endometriyal polibi olan 40 yaş ve üzeri kadınlar daha obez ve daha yüksek bazal FSH ve E2 seviyelerine sahiplerdi. Kırk yaş ve üzeri kadınlarda obezite ve artmış östrojen düzeyleri endometrial polip gelişimi için risk faktörü olabilir.