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Journals / KBB-Forum / 2017 / Cilt: 16 - Sayı: 4

A SALVAGE TREATMENT IN PATIENTS WITH SUDDEN HEARING LOSS: INTRATYMPANIC STEROID

ANİ İŞİTME KAYIPLI HASTALARDA KURTARMA TEDAVİSİ: İNTRATİMPANİK STEROİD

Derya KAYA
FUNDA TÜMKAYA
FAZIL NECDET ARDIÇ
CÜNEYT ORHAN KARA
Bülent Kamil AYKAL
Journal
KBB-Forum
Pages
97–101
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Our study showed thatintratympanic steroid treatment after failure of systemic steroid is effective in all frequencies.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To analyse patients who were treated with intratympanic 4mg/ml dexamethasone injection after failure of systemic steroid treatment.
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Key Findings & Data:Methods: Fifty patients(24 female,26 male) with sudden sensorineural hearing loss and had salvage treatment(intratympanic dexamethasone) between 2008 to 2015 were included.
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Conclusion & Impact:Conclusion: Our study showed thatintratympanic steroid treatment after failure of systemic steroid is effective in all frequencies.
🔬Design:Research Article
📍Scope:2008 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: To analyse patients who were treated with intratympanic 4mg/ml dexamethasone injection after failure of systemic steroid treatment. Methods: Fifty patients(24 female,26 male) with sudden sensorineural hearing loss and had salvage treatment(intratympanic dexamethasone) between 2008 to 2015 were included. Efficacy of treatment was evaluated by average low frequency level(250,500,1000,2000 Hz), average high frequency level(4000,6000,8000 Hz) and speech discrimination score. Results: The difference between pre-treatment (68.99 ±30.71) and post-treatment (62.54±33.81) high frequency average values was statistically significant(p<0.05). The difference between pre-treatment(68.17 ±28.41) and post-treatment (56.95 ±30.56) low frequency average values was statistically significant(p<0.05). The difference between systemic steroid treatment and intratympanic steroid injection low frequency average values was statistically significant(p<0.05). The difference between pre-treatment(55.94 ±32.9) and post-treatment (62.45 ±31.21) speech discrimination scoreswere statistically significant(p<0.05).There was statistically significant difference between patients who had 4 or fewer intratympanic injections and 8 or more injections(p<0.05). Conclusion: Our study showed thatintratympanic steroid treatment after failure of systemic steroid is effective in all frequencies.

Özet

Amaç: Daha önce sistemik steroid tedavisine cevap vermeyen ve kurtarma tedavisi olarak intratimpanik deksametazon uygulaması yapılan hastaların retrospektif olarak incelenmesi. Yöntemler: Bu çalışmada 2008-2015 yılları arasında arasında ani işitme kaybı (AİK) tanısı konan ve kurtarma tedavisi yapılan(intratimpanik deksametazon) 50 (24 kadın, 26 erkek) olgu incelenmiştir.Tedavi etkinliği saf ses odyometrisi alçak frekans (250,500,1000,2000 Hz) ve yüksek frekans (4000,6000,8000 Hz) ortalamaları, konuşmayı ayırt etme yüzdesine göre değerlendirilmiştir. Bulgular: Tedavi öncesindeki yüksek frekans ortalamaları (68,99 ±30,71) ile intratimpanik(İT) steroid enjeksiyonu sonrası değerler (62,54±33,81) arasındaki fark istatiksel olarak anlamlı bulunmuştur (p<0,05). Tedavi öncesindeki alçak frekans ortalaması (68,17 ±28,41) ile İT steroid enjeksiyon sonrası(56,95 ±30,56) alçak frekans ortalaması arasındaki farklılık istatiksel olarak anlamlı bulunmuştur (p<0,05). Sistemik steroid tedavisi sonrasındaki alçak frekans ortalaması ile İT steroid enjeksiyonu alçak frekans ortalaması arasındaki farklılık anlamlı bulunmuştur (p<0,05).Tedavi öncesi konuşmayı ayırt etme skoru (55,94 ±32,9) ve İT steroid enjeksiyon sonrası(62,45 ±31,21) arasındaki fark istatiksel olarak anlamlı bulunmuştur(p<0,05). Yüksek frekans ortalamalarında 4 ve daha az sayıda İT enjeksiyon yapılan hasta grubuyla,8 ve üzeri enjeksiyon yapılan hasta grubu arasındaki fark istatistiksel olarak anlamlı bulunmuştur(p<0,05). Sonuç: Bizim çalışmamızda tüm frekanslarda sistemik steroid tedavisine cevap alınamayan hastalarda intratimpanik steroid tedavisinin etkili olduğu görülmüştür. Bu nedenle sistemik tedavi sonrası intratimpanik tedavinin prognozu olumlu etkilediği düşünülmüştür.

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Cite This Article

KAYA, D., TÜMKAYA, F., ARDIÇ, F. N., KARA, C. O., AYKAL, B. K. (2017). A SALVAGE TREATMENT IN PATIENTS WITH SUDDEN HEARING LOSS: INTRATYMPANIC STEROID. KBB-Forum, Cilt: 16 - Sayı: 4, 97–101. https://ajindex.com/articles/197803

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