AI Summary & Key Takeaways
AI InsightHigh levels of pretreatment SII indicate a probable high risk of perineural and/or lymphovascular invasion and extranodal extension.
📌 3 Key Takeaways
Özet
Introduction: The aim of this study was to evaluate the correlation of the systemic immune-inflammation index (SII) and neutrophil- to-lymphocyte ratio (NLR) with histopathological findings in patients with tongue squamous cell carcinoma (SCC). Methods: 33 patients with tongue SCC were enrolled. The SII (NxP/L) based on neutrophil (N), lymphocyte (L), and platelet (P) counts was used as a biomarker. The results were compared with those of 34 healthy individuals. In addition, the correlation of NLR and SII with the presence of perineural and lymphovascular invasion, extranodal extension, and pathological differentiation degree was studied. Results: Patients with tongue SCC had significantly higher NLR and SII than healthy subjects (p=0.027, p=0.023 respectively). Receiver operating characteristic curve analysis indicated optimal NLR and SII cut-off values to be 1.98 and 477.30, respectively. Comparisons of perineural invasion, lymphovascular invasion, and extranodal extension with SII were statistically significant (p=0.044, p=0.012, p=0.022). Nevertheless, NLR only correlated with extranodal extension (p=0.003). No significant correlation was observed between the pathological degree of tongue SCC and NLR and SII. Discussion and Conclusion: SII is a novel, inexpensive, and useful biomarker that has a predictive value in the disease progression of patients with tongue SCC. High levels of pretreatment SII indicate a probable high risk of perineural and/or lymphovascular invasion and extranodal extension.