Journals / İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi / 2018 / Cilt: 8 - Sayı: 1

Does vitamin D deficiency increase disease severity in atopic dermatitis?

D vitamini eksikliği, atopik dermatitte hastalığın şiddetini arttırır mı?

Pages
31–36
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: In our study, we found no correlations between vitamin D levels and development of atopic dermatitis or disease severity

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Atopic dermatitis is the most common chronic inflammatory, pruritic skin disease of childhood.
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Key Findings & Data:Patients with SCORAD index scores of 50 points were classified in mild, moderate and severe disease groups.
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Conclusion & Impact:Conclusion: In our study, we found no correlations between vitamin D levels and development of atopic dermatitis or disease severity
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Atopic dermatitis is the most common chronic inflammatory, pruritic skin disease of childhood. Role of vitamin D due to its immunomodulatory effects on the pathogenesis of the disease is being discussed recently. In our study, we planned to investigate the correlation between vitamin D deficiency and presence and severity of atopic dermatitis. Methods: Sixty-two patients under the age of five, admitted to Bagcilar Training and Research Hospital Pediatrics Allergy outpatient clinic with the diagnosis of atopic dermatitis were included in the study. Control group consisted of thirty healthy child- ren admitted to our outpatient clinic of children’s health. Eosinophil counts, total IgE and specific IgE levels of the patients with atopic dermatitis were recorded from their patient files. Disease severity was evaluated using SCORAD index. Patients with SCORAD index scores of 50 points were classified in mild, moderate and severe disease groups. Vitamin 25(OH)D levels of ≥30, 21-29, and ≤20 ng/ml were accepted as sufficient, inadequate and deficient vitamin levels. P<0.05 was considered as statistically significant. Results: There were no significant differences in age and sex between cases with atopic dermatitis, and the control group. In %22.6 (n=14) of the atopic dermatitis patients and %3 (n=10) of the control group vitamin D deficiency was detected. Mean 25(OH) D vitamin levels of the patients with low and moderate SCORAD index scores were 39.47±18.49 and 25.07±13.74 points, respectively, without any statistically significant difference between both groups (p=0.059). Conclusion: In our study, we found no correlations between vitamin D levels and development of atopic dermatitis or disease severity

Özet

Amaç: Atopik dermatit çocukluk çağının en sık görülen kronik, kaşıntılı inflamatuvar cilt hastalığıdır. Son yıllarda hastalığın patogenezinde immünmodülatör etkileri ile D vitamininin rolü tartışılmaktadır. Çalışmamızda, D vitamini eksikliği ile atopik dermatit hastalık varlığı ve hastalığın şiddeti ile arasındaki ilişkinin araştırılması planlanmıştır. Yöntem: Bağcılar Eğitim ve Araştırma Hastanesi Çocuk Alerji Polikliniğinde atopik dermatit tanısı alan 5 yaş altı 62 hasta çalışmaya alındı. Kontrol grubunu hastanemiz çocuk sağlığı polikliniğine başvuran aynı yaş grubunda sağlıklı 30 çocuk oluşturdu. Atopik dermatitli olguların hastalık ile ilgili eozinofil, total IgE, spesifik IgE düzeyleri hasta dosyalarından kaydedildi. Hastalık şiddeti SCORAD indeksi kullanılarak değerlendirildi. SCORAD indeks puanı 50 olanlar ağır hastalık grubunu oluşturdu. 25(OH)D düzeyi ≥30 ng/ml yeterli, 21-29 ng/ ml yetersiz, ≤20 ng/ml eksiklik olarak kabul edildi. İstatistiksel analizde p<0,05 değeri anlamlı kabul edildi. Bulgular: Atopik dermatitli olgular ile kontrol grubu arasında yaş, cinsiyet dağılımı açısından anlamlı fark saptanmadı. Olguların %22,6’sında (n=14) D vitamini eksikliği saptanırken, sağlıklı çocukların %3’ünde (n=10) D vitamini eksikliği vardı. SCORAD indeksi hafif olanların 25 (OH) D vitamini ortalaması 39,47±18,49, orta olanların 25 (OH) D vitamini ortalaması 25,07±13,74 olup, her iki grup arasında fark saptanmadı (p=0,059). Sonuç: Çalışmamızda D vitamini düzeyi ile atopik dermatit varlığı ve şiddeti arasında ilişki bulunmamıştır.

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Cite This Article

ŞENER, O. A., BOSTAN, Ö. G., NACAROĞLU, H. T., EROL, M., HAMİLÇIKAN, Ş., YİĞİT, Ö. (2018). Does vitamin D deficiency increase disease severity in atopic dermatitis?. İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi, Cilt: 8 - Sayı: 1, 31–36. https://ajindex.com/articles/196272

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