Extranodal NK/T Cell Lymphoma the Nasal Type on Invasive Fungal Sinusitis

This case is presented to emphasize the importance of differential diagnosis of invasive fungal sinusitis and primary rhinonasal lymphoma in patients without risk factors, such as underlying immunosuppressive condition and uncontrolled diabetes mellitus.

📌 3 Key Takeaways

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Objective & Hypothesis:Nasal type NK/T—cell lymphoma, which accounts for -10% of non-Hodgkin lymphomas, is important due to low survival rates and poor prognosis in primary rhinosarcoma lymphomas.

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Key Findings & Data:This type of non-Hodgkin lymphoma with progressive clinical picture destroying the nose, sinuses, soft and hard palate can be confused with symptoms caused by invasive fungal rhinosinusitis, The underlying nasal type NK/T cell lymphoma is risk for secondary invasive fungal rhinosinusitis that may locally develop damage to the epithelium and invasion of blood vessels.

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Conclusion & Impact:This case is presented to emphasize the importance of differential diagnosis of invasive fungal sinusitis and primary rhinonasal lymphoma in patients without risk factors, such as underlying immunosuppressive condition and uncontrolled diabetes mellitus.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Nasal type NK/T—cell lymphoma, which accounts for -10% of non-Hodgkin lymphomas, is important due to low survival rates and poor prognosis in primary rhinosarcoma lymphomas. This type of non-Hodgkin lymphoma with progressive clinical picture destroying the nose, sinuses, soft and hard palate can be confused with symptoms caused by invasive fungal rhinosinusitis, The underlying nasal type NK/T cell lymphoma is risk for secondary invasive fungal rhinosinusitis that may locally develop damage to the epithelium and invasion of blood vessels. This article is aimed at presenting case of pathologically diagnosed nasal type NK/ cell lymphoma which is suspected of invasive fungal rhinosinusitis, empirically initiated antifungal therapy and Aspergillus flavus isolated in tissue culture. This case is presented to emphasize the importance of differential diagnosis of invasive fungal sinusitis and primary rhinonasal lymphoma in patients without risk factors, such as underlying immunosuppressive condition and uncontrolled diabetes mellitus.

Özet

Non-Hodgkin lenfomaların %5-10'unu oluşturan nazal tip NK/T hücreli lenfoma, primer rinonazal lenfomaların içinde düşük sağkalım oranları ve kötü prognozu nedeniyle önem kazanmaktadır. Bu non-Hodgkin lenfoma tipi burun, sinüsler, sert ve yumuşak damağı destrükte ederek, progresif bir klinik tablo ile seyreder. Neden olduğu semptomlar ile invaziv fungal rinosinüzitlerle karışabildiği gibi, altta yatan nazal tip NK/T hücreli lenfomanın hastalarda lokal olarak yarattığı epiteldeki hasar, kan damarlarının invazyonu da sekonder olarak gelişebilecek invaziv fungal rinosinüzitler için risk oluşturmaktadır. Bu yazıda invaziv fungal rinosinüzit şüphesiyle ampirik olarak antifungal tedavi başlanan ve doku kültüründe Aspergillus flavus üremesi olup, patolojiye gönderilen örneklerde nazal tip ekstranodal NK/T hücreli lenfoma tanısı alan bir olgu sunulmuştur. Bu olgu altta yatan immünsüpresif durum, kontrolsüz diabetes mellitus gibi risk faktörleri olmayan hastalarda invaziv fungal sinüzitler ile primer rinonazal lenfoma ayırıcı tanısı yapılmasının önemini vurgulamak amacıyla sunulmuştur

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Cite This Article

ERASLAN, C., PULLUKÇU, H., HEKİMGİL, M., METİN, D. Y., VERAL, A., YILDIRIM, Ç., TAŞBAKAN, M. I., MİDİLLİ, R., AVŞAR, C. B. (2017). Extranodal NK/T Cell Lymphoma the Nasal Type on Invasive Fungal Sinusitis. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, Cilt: 22 - Sayı: 3, 126–131. https://ajindex.com/articles/196154

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