Journals / Journal of Basic and Clinical Health Sciences / 2021 / Cilt: 5 - Sayı: 2

Ancient DNA Research: Ongoing Challenges and Contribution to Medical Sciences

Pages
182–189
Publication Date
2021-05-27
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In the present review, molecular studies carried out to date, contributions of ancient DNA to medical sciences, as well as basic problems encountered in obtaining and using aDNA have been discussed.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Life gave rise on our planet 3-4 billion years ago and since then, living organisms (from one cell to multicellular organisms) have undergone many genetic, phenotypic and communal changes.
📊
Key Findings & Data:For the past 30 years ancient DNA studies have aided us in understanding the molecular basis of the changes observed in living organisms.
💡
Conclusion & Impact:In the present review, molecular studies carried out to date, contributions of ancient DNA to medical sciences, as well as basic problems encountered in obtaining and using aDNA have been discussed.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:ancient DNA · medical sciences · aDNA researches

Abstract

Life gave rise on our planet 3-4 billion years ago and since then, living organisms (from one cell to multicellular organisms) have undergone many genetic, phenotypic and communal changes. Scientists have been able to shed light on only a small part of this evolutionary process, but with the development of new techniques our knowledge is expanding day by day. For the past 30 years ancient DNA studies have aided us in understanding the molecular basis of the changes observed in living organisms. Ancient DNA (aDNA) is the genetic material obtained from biological remains (bones, teeth, plant seeds, etc.) acquired from archaeological and paleontological excavations. In the present review, molecular studies carried out to date, contributions of ancient DNA to medical sciences, as well as basic problems encountered in obtaining and using aDNA have been discussed.

🔖

Cite This Article

YÜCE, Z., EFE, H., YOCA, Ö. U. (2021). Ancient DNA Research: Ongoing Challenges and Contribution to Medical Sciences. Journal of Basic and Clinical Health Sciences, Cilt: 5 - Sayı: 2, 182–189. https://ajindex.com/articles/196021

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (20)

  1. Singh J, Garg A. Ancient DNA analysis and its probable applications in forensic anthropology. J Punjab Acad Forensic Med Toxicol. 2014;14(1):43–50
  2. Singh J, Garg A. Ancient DNA analysis and its probable applications in forensic anthropology. J Punjab Acad Forensic Med Toxicol. 2014;14(1):43–50
  3. Tekeli E, Elma C. Antropoloji̇k kemi̇k örnekleri̇nden anti̇k dna çalişmalari. 2016;32(Aralık)
  4. Tekeli E, Elma C. Antropoloji̇k kemi̇k örnekleri̇nden anti̇k dna çalişmalari. 2016;32(Aralık)
  5. Higuchi R, Bowman B, Freiberger M, Ryder OA, Wilson AC. DNA sequences from the quagga, an extinct member of the horse family. Nature. 1984;312(5991):282–4
  6. Higuchi R, Bowman B, Freiberger M, Ryder OA, Wilson AC. DNA sequences from the quagga, an extinct member of the horse family. Nature. 1984;312(5991):282–4
  7. Lindahl T. Instability and decay of the primary structure of DNA. Nature. 1993;362:709–15
  8. Lindahl T. Instability and decay of the primary structure of DNA. Nature. 1993;362:709–15
  9. Hagelberg E, Hofreiter M, Keyser C. Ancient DNA: the first three decades. Philos Trans R Soc Lond B Biol Sci. 2015;370(1660):20130371
  10. Hagelberg E, Hofreiter M, Keyser C. Ancient DNA: the first three decades. Philos Trans R Soc Lond B Biol Sci. 2015;370(1660):20130371
  11. Goffeau A, Barrell G, Bussey H, Davis RW, Dujon B, Feldmann H, et al. Life with 6000 genes. Science (80- ). 1996;274(5287):546–67
  12. Goffeau A, Barrell G, Bussey H, Davis RW, Dujon B, Feldmann H, et al. Life with 6000 genes. Science (80- ). 1996;274(5287):546–67
  13. Kchouk M, Gibrat JF, Elloumi M. Generations of Sequencing Technologies: From First to Next Generation. Biol Med. 2017;09(03)
  14. Kchouk M, Gibrat JF, Elloumi M. Generations of Sequencing Technologies: From First to Next Generation. Biol Med. 2017;09(03)
  15. Orlando L, Ginolhac A, Zhang G, Froese D, Albrechtsen A, Stiller M, et al. Recalibrating equus evolution using the genome sequence of an early Middle Pleistocene horse. Nature. 2013;499(7456):74–8
  16. Orlando L, Ginolhac A, Zhang G, Froese D, Albrechtsen A, Stiller M, et al. Recalibrating equus evolution using the genome sequence of an early Middle Pleistocene horse. Nature. 2013;499(7456):74–8
  17. Li R. FORENSIC BIOLOGY. 2nd ed. CRC Press; 2015. 567 p
  18. Li R. FORENSIC BIOLOGY. 2nd ed. CRC Press; 2015. 567 p
  19. Elkins KM. Forensic DNA Biology: a Laboratory Manual, Chapter 4. Elsevier; 2012. 39-52 p
  20. Elkins KM. Forensic DNA Biology: a Laboratory Manual, Chapter 4. Elsevier;