Journals / Dicle Tıp Dergisi / 2018 / Cilt: 45 - Sayı: 4

Retrospective Investigation Of Factors Affecting Early Period Mortality And Morbidity After Operation In Type A Aortic Dissections

Tip A Aort Diseksiyonlarında Operasyon Sonrası Erken Dönem Mortalite ve Morbidite Üzerine Etki Eden Faktörlerin Retrospektif İncelenmesi

Pages
387–396
DOI
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Conclusion: Determining of factors affecting mortality in type A aortic dissections in larger patient populations and taking precautions for these factors may be effective in reducing mortality and morbidity

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Aortic dissection is still an important cause of both mortality and morbidity.
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Key Findings & Data:Many factors affect surgical outcomes in patients operated for type A aortic dissection.
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Conclusion & Impact:Conclusion: Determining of factors affecting mortality in type A aortic dissections in larger patient populations and taking precautions for these factors may be effective in reducing mortality and morbidity
🔬Design:Review & Systematic Survey
📍Scope:2006 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: Aortic dissection is still an important cause of both mortality and morbidity. Many factors affect surgical outcomes in patients operated for type A aortic dissection. Sufficient identification of these factors will affect the success of the treatment. Methods: Preoperative, intraoperative, and postoperative data of 140 patients who were diagnosed with type A aortic dissection between January 2006 and December 2016 were retrospectively reviewed from patient records and hospital information management system records. Quantative parameters between groups were compared with Student t or Mann-Whitney U tests, and qualitative data were compared with Chi-square test. Results: The mean age of the patients who comprised 31 (22.2%) female and 109 (77.8%) male was 57.1 ± 12.3 (min: 27 to max: 84). The majority of patients underwent isolated ascending aorta replacement or hemiarchus replacement with ascending aorta (%70). Antegrade cerebral perfusion (ACP) and rarely retrograde cerebral perfusion (RCP) were used as the brain preservation method. Total mortality in all patients was 37 (26.4%). The systolic pressure that was below 90 mmHg at the time of admission, the presence of major neurological deficits and past cardiac surgical history had a significant impact on mortality (p<0.05). In patients with mortality, perfusion time inotropic needs and intensive care hospitalization time were statistically significantly higher (p<0.05). The duration of intensive care unit and mortality were significantly higher in the RCP group compared to the patients receiving ACP (p=0.02, p=0.04, respectively). Conclusion: Determining of factors affecting mortality in type A aortic dissections in larger patient populations and taking precautions for these factors may be effective in reducing mortality and morbidity

Özet

Amaç: Aortik diseksiyon günümüzde hala önemli bir mortalite ve morbidite nedenidir. Tip A aort diseksiyonu nedeniyle ameliyat edilen hastalarda birçok faktör cerrahi sonuçları etkilemektedir. Bu faktörlerin yeterince belirlenmesi tedavinin başarılı olmasına etki edecektir. Yöntemler: Kliniğimizde Ocak 2006 - Aralık 2016 yılları arasında Tip A aort diseksiyonu tanısı ile opere edilen 140 hastanın preoperatif, intraoperatif, ve postoperatif verileri, hasta dosyaları ve hastane bilgi yönetim sistem kayıtlarından retrospektif olarak araştırıldı. Gruplar arası niceliksel parametreler Student t veya Mann-Whitney U testleri ile, niteliksel veriler ise Ki-Kare testi ile karşılaştırıldı. Bulgular: Hastalarda ortalama yaş 57.1±12.3 (min: 27 ile max: 84), 31’i (%22,2) kadın, 109’u (%77,8) erkekti. Hastaların çoğunluğuna izole asendan aorta replasmanı veya asendan aorta ile birlikte hemiarkus replasmanı uygulandı (%70). Beyin koruma yöntemi olarak çoğunlukla antegrad serebral perfüzyon (ASP) nadiren retrograd serebral perfüzyon (RSP) kullanıldı. Tüm hastalarda total mortalite 37 kişi (%26,4) idi. Başvuru anında sistolik tansiyonun 90 mmHg altında olması, majör nörolojik defisit varlığı, hastada geçirilmiş kardiyak cerrahi öyküsü olmasının mortaliteyi anlamlı oranda etkilediği saptanmıştır (p<0.05). Mortalite olan hastalarda perfüzyon süreleri uzun, inotrop ihtiyacı fazla, yoğun bakım yatış süreleri istatiksel olarak anlamlı derecede yüksekti (p<0.05). RSP yapılan grupta yoğun bakımda kalış süreleri ve mortalite, ASP uygulanan hastalara göre anlamlı oranda yüksekti (sırası ile p=0.02, p=0.04). Sonuç: Tip A aortik diseksiyonlarda mortalite üzerine etki eden faktörlerin daha büyük hasta serilerinde ortaya konulması ve bu faktörlere yönelik tedbirlerin alınması mortalite ve morbiditenin azaltılmasında etkili olabilir.

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Cite This Article

ENGİN, M., GÖNCÜ, M. T., GÜVENÇ, O., SAVRAN, M., ÖZYAZICIOĞLU, A. F. (2018). Retrospective Investigation Of Factors Affecting Early Period Mortality And Morbidity After Operation In Type A Aortic Dissections. Dicle Tıp Dergisi, Cilt: 45 - Sayı: 4, 387–396. https://ajindex.com/articles/190529

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