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Journals / GORM:Gynecology Obstetrics & Reproductive Medicine / 2016 / Cilt: 22 - Sayı: 1

Beta-Human Chorionic Gonadotropin and Uterine Artery Doppler Measurements for the Prediction of Success of Single Dose Methotrexate Treatment in Tubal Ectopic Pregnancies

Çiğdem KILIÇ
Mehmet Metin ALTAY
Tuğba KINAY
Metin KAPLAN
Serap FIRTINA TUNCER
ENİS ÖZKAYA
Ahmet Okyar EROL
Orhan GELİŞEN
Pages
22–26
DOI
—
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However, no significant alteration of uterine artery Dopplermeasurements was determined on the same days.CONCLUSION: Reduction rate in the ?-HCG level on day 4 of treatment can be used in determinationthe success of single-dose methotrexate therapy.

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Objective & Hypothesis:OBJECTIVES: To evaluate the impact of the uterine artery Doppler values and the change of ?-Humanchorionic gonadotropin (?-HCG) levels from day 0 to day 4 for prediction of the success of single dosemethotrexate treatment in tubal pregnancy cases.
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Key Findings & Data:STUDY DESIGN: 50 patients with tubal pregnancy were included the prospective study.
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Conclusion & Impact:However, no significant alteration of uterine artery Dopplermeasurements was determined on the same days.CONCLUSION: Reduction rate in the ?-HCG level on day 4 of treatment can be used in determinationthe success of single-dose methotrexate therapy.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTIVES: To evaluate the impact of the uterine artery Doppler values and the change of ?-Humanchorionic gonadotropin (?-HCG) levels from day 0 to day 4 for prediction of the success of single dosemethotrexate treatment in tubal pregnancy cases. STUDY DESIGN: 50 patients with tubal pregnancy were included the prospective study. The locationand size of ectopic pregnancy, bilateral uterine artery pulsed color doppler imaging was examined by ultrasonography and serum ?-HCG levels were measured on day 0, 4, 7 of treatment. Success was defined as decrease of ?-HCG level <10 mIU/mL with single dose methotrexate treatment. Multiple dosemethotrexate treatment and surgical treatment were considered as treatment failure.RESULTS: 32 patients (64%) treated with single dose methotrexate, 14 patients (28%) treated with multiple dose methotrexate, and 4 patients (8%) treated with surgery. In the group with ?-HCG level decrease > 15.04% on day 4, single-dose methotrexate therapy were 3.82 times more successful than thegroup without > 15.04% ?-HCG decrease. However, no significant alteration of uterine artery Dopplermeasurements was determined on the same days.CONCLUSION: Reduction rate in the ?-HCG level on day 4 of treatment can be used in determinationthe success of single-dose methotrexate therapy.

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Cite This Article

KILIÇ, Ç., ALTAY, M. M., KINAY, T., KAPLAN, M., TUNCER, S. F., ÖZKAYA, E., EROL, A. O., GELİŞEN, O. (2016). Beta-Human Chorionic Gonadotropin and Uterine Artery Doppler Measurements for the Prediction of Success of Single Dose Methotrexate Treatment in Tubal Ectopic Pregnancies. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 22 - Sayı: 1, 22–26. https://ajindex.com/articles/186405

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