A New Ursane-type Triterpenoid from Salvia santolinifolia

Objective & Hypothesis:Santolinoic acid (1), a new ursane-type triterpene was isolated from the chloroform soluble fraction of Salvia santolinifolia.

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Key Findings & Data:Its structure was established as 2a, 3b, 9a-trihydroxyurs-12-en-28-oic acid on the basis of spectroscopic analysis, including high resolution mass spectroscopy, and 1- and 2-dimensional NMR techniques.

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Conclusion & Impact:The compound (1) showed inhibitory activity against the enzymes acetylcholinesterase and butyrylcholinesterase.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Salvia santolinifolia · Labiatae · triterpenoid

Abstract

Santolinoic acid (1), a new ursane-type triterpene was isolated from the chloroform soluble fraction of Salvia santolinifolia. Its structure was established as 2a, 3b, 9a-trihydroxyurs-12-en-28-oic acid on the basis of spectroscopic analysis, including high resolution mass spectroscopy, and 1- and 2-dimensional NMR techniques. The compound (1) showed inhibitory activity against the enzymes acetylcholinesterase and butyrylcholinesterase.

Özet

Santolinoic acid (1), a new ursane-type triterpene was isolated from the chloroform soluble fraction of Salvia santolinifolia. Its structure was established as 2a, 3b, 9a-trihydroxyurs-12-en-28-oic acid on the basis of spectroscopic analysis, including high resolution mass spectroscopy, and 1- and 2-dimensional NMR techniques. The compound (1) showed inhibitory activity against the enzymes acetylcholinesterase and butyrylcholinesterase.

Keywords

Salvia santolinifolia Labiatae triterpenoid enzyme inhibition

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Cite This Article

AHMAD, Z., MEHMOOD, S., IFZAL, R., MALIK, A. (2007). A New Ursane-type Triterpenoid from Salvia santolinifolia. Turkish Journal of Chemistry, Cilt: 31 - Sayı: 4, 495–501. https://ajindex.com/articles/185484

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